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公开(公告)号:US20140221941A1
公开(公告)日:2014-08-07
申请号:US14129200
申请日:2012-06-28
Applicant: Signe Erickson , Darren Doud , Eugene de Juan, JR. , Yair Alster , Cary J. Reich , Kathleen Cogan Farinas
Inventor: Signe Erickson , Darren Doud , Eugene de Juan, JR. , Yair Alster , Cary J. Reich , Kathleen Cogan Farinas
IPC: A61F9/00
CPC classification number: A61F9/0017 , A61B10/0045 , A61F2250/0067
Abstract: An apparatus to treat a patient comprises a container to receive fluid of a device implanted in the eye. The fluid of the device can be analyzed to determine a component of the vitreous humor of the eye.
Abstract translation: 用于治疗患者的装置包括容纳植入眼中的装置的流体的容器。 可以分析装置的流体以确定眼睛玻璃体液的一个组成部分。
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公开(公告)号:US20130204209A1
公开(公告)日:2013-08-08
申请号:US13831695
申请日:2013-03-15
Applicant: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
Inventor: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC: A61F9/00
CPC classification number: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号:US20120310133A1
公开(公告)日:2012-12-06
申请号:US13555056
申请日:2012-07-20
Applicant: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
Inventor: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC: A61F9/00
CPC classification number: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
Abstract: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
Abstract translation: 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置,以便至少部分地符合消融的基质表面,以便矫正视力。 适形的内部部分可以具有至少一些刚性,以便平滑上皮,使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量,以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。
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公开(公告)号:US08298578B2
公开(公告)日:2012-10-30
申请号:US13252942
申请日:2011-10-04
Applicant: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
Inventor: Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC classification number: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
Abstract translation: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。
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公开(公告)号:US20120095439A1
公开(公告)日:2012-04-19
申请号:US13204638
申请日:2011-08-05
Applicant: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
Inventor: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
IPC: A61M31/00 , A61M5/32 , A61P27/02 , C07K16/18 , A61K39/395
CPC classification number: A61F9/0017 , A61K9/0051 , A61K38/179 , A61K39/395 , A61K45/06 , A61M37/00 , C07K16/22 , C07K2317/94 , A61K2300/00
Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
Abstract translation: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。
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公开(公告)号:US20120029445A1
公开(公告)日:2012-02-02
申请号:US13252998
申请日:2011-10-04
Applicant: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
Inventor: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC classification number: G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
Abstract translation: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。
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公开(公告)号:US20100036488A1
公开(公告)日:2010-02-11
申请号:US12384659
申请日:2009-04-06
Applicant: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
Inventor: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
IPC: A61F2/14
CPC classification number: A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
Abstract: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
Abstract translation: 用于治疗上皮缺损的治疗镜片包括设置在基质和/或Bowman膜上的治疗材料层,以抑制从泪液到基质和/或Bowman膜的水流,使得可以恢复角膜deturgescence 减少角膜肿胀和光散射。 该层可以覆盖并保护神经纤维以减轻疼痛。 该层可以包括折射率以抑制从基质和/或Bowman膜的前表面的光散射。 透镜可以包括弯曲的前表面,当上皮再生时,该前表面为患者提供功能视觉。 治疗材料层可以以许多方式定位在眼睛上,例如通过固化以将该层粘附到基质和/或Bowman膜的暴露表面上的喷雾。
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公开(公告)号:US07275830B2
公开(公告)日:2007-10-02
申请号:US10398375
申请日:2001-10-07
Applicant: Yair Alster , Omer Refaeli , Barak Azmon
Inventor: Yair Alster , Omer Refaeli , Barak Azmon
IPC: A61B3/02
CPC classification number: A61B5/0002 , A61B3/0091 , A61B3/024 , A61B3/032 , A61B3/12
Abstract: Methods and systems for performing an eye test and for detecting eye disease. A test pattern is presented to an individual. The individual fixates an eye on a fixation target. The test pattern is then hidden and a second test pattern is displayed at a different location. The individual then compares the perceived second test pattern with a pre-defined reference pattern. These steps are repeated several times, while varying the location of presentation of the patterns. Alternatively, the individual fixates on a presented fixation target. A test pattern is presented to the patient and then disappears. The individual compares the perceived pattern, with a pre-defined reference pattern. These steps are repeated while changing the location of presentation of the test pattern. It may then be determined whether the individual has an eye disease based on the comparisons.
Abstract translation: 用于进行眼睛检查和检测眼睛疾病的方法和系统。 向个人呈现测试模式。 个人将眼睛固定在固定目标上。 然后隐藏测试图案,并且在不同的位置显示第二测试图案。 然后,个体将感知的第二测试图案与预定义的参考图案进行比较。 这些步骤重复几次,同时改变模式的呈现位置。 或者,个体固定在所呈现的固定目标上。 测试模式呈现给患者,然后消失。 个人将感知模式与预定义的参考模式进行比较。 在改变测试图案呈现的位置的同时重复这些步骤。 然后可以根据比较来确定个体是否患有眼睛疾病。
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公开(公告)号:US20050122477A1
公开(公告)日:2005-06-09
申请号:US10505072
申请日:2003-02-19
Applicant: Yair Alster , Omer Rafaeli , Barak Azmon
Inventor: Yair Alster , Omer Rafaeli , Barak Azmon
Abstract: Methods and a device comprising a controller/processor unit (664), a visual test-pattern unit (660), a competing sensory stimuli generating unit (662), a user input device (666), an ouput device (668) and a storage unit (670) for detecting eye disease and for assessing the clinical stage of an eye disease in an individual is disclosed. The methods include projecting test patterns onto the retina of a tested eye and subjecting the individual to a competing sensory stimuli. The competing stimuli may be of various different sensory modalities including visual, auditory, or other sensory modalities. If the individual perceives a difference in at least one localized part of the perceived image of a test pattern as compared to a predefined reference pattern, the individual provides a response indicative of the difference or differences. The responses are processed to assess the severity of eye disease if a disease is detected, or to determine the clinical stage of a detected eye disease.
Abstract translation: 方法和装置,包括控制器/处理器单元(664),视觉测试图案单元(660),竞争感觉刺激产生单元(662),用户输入设备(666),输出设备(668)和 公开了一种用于检测眼睛疾病和评估个体眼部疾病的临床阶段的存储单元(670)。 这些方法包括将测试图案投影到测试眼睛的视网膜上并使个体受到竞争的感觉刺激。 相互竞争的刺激可能是各种不同的感官模式,包括视觉,听觉或其他感官模式。 如果个人感知到与预定义的参考模式相比,测试图案的感知图像的至少一个本地化部分的差异,则个人提供指示差异或差异的响应。 处理这些反应以评估如果检测到疾病的眼病的严重性,或者确定检测到的眼睛疾病的临床阶段。
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