System and method for non-invasive measurement of analytes in vivo

    公开(公告)号:US11965781B2

    公开(公告)日:2024-04-23

    申请号:US18312730

    申请日:2023-05-05

    Abstract: A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

    SPECTRAL FEATURE CONTROL APPARATUS
    426.
    发明申请

    公开(公告)号:US20230124587A1

    公开(公告)日:2023-04-20

    申请号:US18081971

    申请日:2022-12-15

    Applicant: Cymer, LLC

    Abstract: A spectral feature selection apparatus includes a dispersive optical element arranged to interact with a pulsed light beam; three or more refractive optical elements arranged in a path of the pulsed light beam between the dispersive optical element and a pulsed optical source; and one or more actuation systems, each actuation system associated with a refractive optical element and configured to rotate the associated refractive optical element to thereby adjust a spectral feature of the pulsed light beam. At least one of the actuation systems is a rapid actuation system that includes a rapid actuator configured to rotate its associated refractive optical element about a rotation axis. The rapid actuator includes a rotary stepper motor having a rotation shaft that rotates about a shaft axis that is parallel with the rotation axis of the associated refractive optical element.

    Method and apparatus for processing terahertz spectral imaging data

    公开(公告)号:US11422031B2

    公开(公告)日:2022-08-23

    申请号:US15930296

    申请日:2020-05-12

    Abstract: A method for collecting and processing terahertz spectral imaging data includes: scanning an object to generate terahertz spectral data having a hyper- or low-spectral resolution respectively at a plurality of pixel points; collecting the terahertz spectral data and recording coordinate data of each pixel point, thereby obtaining a mixed data including a hyper-spectral data and a low-spectral data corresponding to different pixel points; constructing a hyper-spatial and low-spectral imaging data-cube from the mixed data; extracting a hyper-spectral data-set from the mixed data; and reconstructing a hyper-spatial and hyper-spectral imaging data-cube from the hyper-spatial and low-spectral imaging data-cube based on the hyper-spectral data-set. A terahertz spectral imaging apparatus is further provided.

    Compact infrared spectrometer systems and methods for measuring vibrational spectrum of materials and substances

    公开(公告)号:US11378450B2

    公开(公告)日:2022-07-05

    申请号:US16713398

    申请日:2019-12-13

    Abstract: Systems and methods for measuring a fundamental mode vibrational spectrum of materials and substances in the Mid-IR spectral range of 2.5 μm to 14 μm wavelength. are disclosed herein. In one embodiment, a Mid-infrared absorption spectrometer (MIRAS) system includes an infrared Micro-Electro-Mechanical System (MEMS) single element emitter light source. The light source is electrically pulsed and emits electromagnetic radiation in the wavelength range from 2.5 μm to 14 μm and has an integral energy concentrating optic to provide energy for a spectral absorption process. The system includes a scanning high-efficiency infrared spectral grating with self-calibrating feature, configured so that incident energy having absorption information for the spectral absorption process of a sample is within a predefined threshold of a grating blaze angle. The system also includes a single-element thermal detector to receive output energy having the absorption information from the infrared spectral grating.

    Accessories for handheld spectrometer

    公开(公告)号:US11333552B2

    公开(公告)日:2022-05-17

    申请号:US16803210

    申请日:2020-02-27

    Applicant: Verifood, Ltd.

    Abstract: A protective sheath having a closed end and an open end is sized to receive a hand held spectrometer. The spectrometer can be placed in the sheath to calibrate the spectrometer and to measure samples. In a calibration orientation, an optical head of the spectrometer can be oriented toward the closed end of the sheath where a calibration material is located. In a measurement orientation, the optical head of the spectrometer can be oriented toward the open end of the sheath in order to measure a sample. To change the orientation, the spectrometer can be removed from the sheath container and placed in the sheath container with the calibration orientation or the measurement orientation. Accessory container covers can be provided and placed on the open end of the sheath with samples placed therein in order to provide improved measurements.

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