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373 条记录 (耗时 0.055 秒)

    Deuterated pyrazino[2,1-a]isoquinolines for the treatment of diseases and/or conditions
    34.
    发明授权
    Deuterated pyrazino[2,1-a]isoquinolines for the treatment of diseases and/or conditions 有权
    用于治疗疾病和/或病症的氘代吡嗪并[2,1-a]异喹啉

    公开(公告)号：US09199986B2

    公开(公告)日：2015-12-01

    申请号：US14030617

    申请日：2013-09-18

    申请人： Concert Pharmaceuticals, Inc.

    发明人： Julie F. Liu ,  Scott L. Harbeson ,  Roger D. Tung

    IPC分类号： C07D241/38 ,  C07D471/04 ,  A61K31/4184 ,  A61K31/4985 ,  A61K45/06

    CPC分类号： C07D471/04 ,  A61K31/4184 ,  A61K31/4985 ,  A61K45/06 ,  Y02A50/411 ,  Y02A50/423 ,  A61K2300/00

    摘要： This invention relates to novel compounds that are pyrazinoisoquinoline derivatives of Formula I: and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel pyrazinoisoquinoline derivatives that are derivatives of praziquantel. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an antihelminthic agent, such as praziquantel.

    摘要翻译： 本发明涉及式I的吡嗪并异喹啉衍生物的新化合物及其药学上可接受的盐。 更具体地，本发明涉及作为吡喹酮衍生物的新型吡嗪异喹啉衍生物。 本发明还提供包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗通过施用抗栓剂如吡喹酮有益治疗的疾病和病症的方法中的用途。

    Organic light emitting device and display unit
    36.
    发明授权
    Organic light emitting device and display unit 有权
    有机发光装置和显示单元

    公开(公告)号：US09093664B2

    公开(公告)日：2015-07-28

    申请号：US11828746

    申请日：2007-07-26

    申请人： Mitsuhiro Kashiwabara

    发明人： Mitsuhiro Kashiwabara

    IPC分类号： H01L51/54 ,  C09K11/06 ,  H01L27/32 ,  H01L51/52 ,  H01L51/50 ,  H01L51/00 ,  C07D241/38

    CPC分类号： H01L51/5265 ,  C07D241/38 ,  H01L27/3244 ,  H01L51/0058 ,  H01L51/006 ,  H01L51/0072 ,  H01L51/0081 ,  H01L51/5088 ,  H01L51/5092 ,  H01L51/5206 ,  H01L51/5221 ,  H01L51/5253 ,  H01L51/5271 ,  H01L2251/558

    摘要： An organic light emitting device capable of improving the light extraction characteristics while suppressing the driving voltage and improving the luminescent performance, and a display unit using it are provided. The organic light emitting device includes: a lamination structure that includes a cathode, a plurality of layers including a light emitting layer made of an organic material, and an anode including a metal thin film in this order, in which the cathode is reflective and the anode is semi-transparent to light generated in the light emitting layer; and a resonator structure that resonates the light generated in the light emitting layer between the cathode and the anode.

    摘要翻译： 提供能够在抑制驱动电压并提高发光性能的同时提高光提取特性的有机发光装置，以及使用该发光装置的显示装置。 有机发光器件包括：层叠结构，其包括阴极，包括由有机材料制成的发光层的多个层以及包括金属薄膜的阳极，其中阴极是反射性的， 阳极对于在发光层中产生的光半透明; 以及谐振器结构，其谐振在阴极和阳极之间的发光层中产生的光。

    Process for producing substituted benzo[F]imidazo[1,2-A]quinoxalin-3(11H)-ones
    37.
    发明授权
    Process for producing substituted benzo[F]imidazo[1,2-A]quinoxalin-3(11H)-ones 有权
    取代苯并[F]咪唑并[1,2-A]喹喔啉-3（11H）酮的制备方法

    公开(公告)号：US08975403B2

    公开(公告)日：2015-03-10

    申请号：US14189706

    申请日：2014-02-25

    申请人： JNC Corporation ,  National University Corporation Tokyo Medical and Dental University

    发明人： Satoshi Inouye ,  Yuiko Miura ,  Suguru Yoshida ,  Takamitsu Hosoya

    IPC分类号： C07D241/36 ,  C07D487/04 ,  C07D241/38 ,  C07D241/44 ,  C07D241/54

    CPC分类号： C07D241/38 ,  C07D241/20 ,  C07D241/44 ,  C07D241/54 ,  C07D487/04 ,  Y02P20/55

    摘要： A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

    摘要翻译： 已经需要制备v-肠溶纤维素化合物的简单方法。 本发明描述了一种制备由通式（II）表示的β-环糊精化合物的方法，包括（1）在碱存在下使通式（Ⅷ）化合物与甲基三苯基鏻盐反应，得到由 通式（IX），（2）对选自由通式（IX）表示的化合物和作为化合物的通式（X）的化合物的任何一种进行闭环复分解反应的步骤 的通式（IX）的化合物，其中氨基被R 5保护，然后使R 4和（如果有的话）R 5脱保护，得到由通式（XIV）表示的v-内网络胺化合物，和（3） 通式（XIV）与通式（XV）表示的化合物反应，得到通式（II）的化合物。