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公开(公告)号:US12109395B2
公开(公告)日:2024-10-08
申请号:US16764041
申请日:2018-11-15
申请人: SANOFI
发明人: Michael Schabbach , Claus Geiger , Andrea Heiberger , Dieter Kadereit , Charlotte Emma Harvey , Congyi Huang , Timothy Charles Frearson , Alexander David Norman
CPC分类号: A61M5/19 , A61J1/201 , A61J1/2093 , A61M5/2066 , A61M5/31596
摘要: The disclosure refers to a device, for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution. The device is adapted such that activation of the device causes movement one of a first piston and a second piston in second chamber in an axial direction of the device, thereby moving the other one of the first piston and the second piston into the same axial direction of the device, opening a fluid communication path between the second chamber and a first chamber of the device, and expelling a second material from the second chamber into the first chamber via the fluid communication path. The disclosure is further directed to a respective mixing and/or reconstitution method.
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公开(公告)号:US20200330686A1
公开(公告)日:2020-10-22
申请号:US16763282
申请日:2018-11-15
申请人: SANOFI
发明人: Michael Schabbach , Dieter Kadereit , Andrea Heiberger , Claus Geiger , Charlotte Emma Harvey , Congyi Huang , Timothy Charles Frearson , Alexander David Norman
摘要: A mixing and/or reconstitution system reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time. The system comprises a device containing a first material within a first chamber, a housing, and a plunger, the plunger comprising a second chamber containing a second material, wherein one of the first and the second material is a fluid, and a movable element with an electric, magnetic, or paramagnetic characteristic, wherein the second chamber is initially closed; and a base unit comprising a recess for accommodation of the device, a control unit, and an electromagnetic unit which is adapted to produce an electromagnetic field penetrating the recess, wherein the control unit can electrically operate the electromagnetic unit such that the element contained in the second chamber moves in a direction of the device determined by the electromagnetic field and fluidly communicates the first and second chambers.
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公开(公告)号:US10792367B2
公开(公告)日:2020-10-06
申请号:US15829596
申请日:2017-12-01
申请人: SANOFI
发明人: Dieter Kadereit , Michael Wagner , Thomas Olpp , Nino Meyer , Martin Bossart , Andreas Evers , Peyman Sakhaii , Pradeep K. Dhal , Paul Konowicz , James E. Stefano , Nils Poth
IPC分类号: A61K38/17 , A61K47/61 , A61K47/54 , A61K47/69 , A61P3/04 , A61P3/10 , A61K9/00 , A61K31/728 , A61K38/26 , A61K47/36
摘要: The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon receptor agonist, a linker and a hyaluronic acid hydrogel bearing -L1-L2-L-Y—R20 groups, wherein Y represents an GLP-1/Glucagon receptor agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon receptor agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising the conjugates as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon receptor agonist.
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公开(公告)号:US20200276388A1
公开(公告)日:2020-09-03
申请号:US16764041
申请日:2018-11-15
申请人: SANOFI
发明人: Michael Schabbach , Claus Geiger , Andrea Heiberger , Dieter Kadereit , Charlotte Emma Harvey , Congyi Huang , Timothy Charles Frearson , Alexander David Norman
摘要: The disclosure refers to a device, for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution. The device is adapted such that activation of the device causes movement one of a first piston and a second piston in second chamber in an axial direction of the device, thereby moving the other one of the first piston and the second piston into the same axial direction of the device, opening a fluid communication path between the second chamber and a first chamber of the device, and expelling a second material from the second chamber into the first chamber via the fluid communication path. The disclosure is further directed to a respective mixing and/or reconstitution method.
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公开(公告)号:US09789165B2
公开(公告)日:2017-10-17
申请号:US14569055
申请日:2014-12-12
申请人: Sanofi
发明人: Dieter Kadereit , Katrin Lorenz , Andreas Evers , Torsten Haack , Michael Wagner , Bernd Henkel , Martin Lorenz , Siegfried Stengelin
IPC分类号: A61K38/26 , A61K45/06 , C07K14/605 , C07K14/575
CPC分类号: A61K38/26 , A61K45/06 , C07K14/57563 , C07K14/605
摘要: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
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公开(公告)号:US09694053B2
公开(公告)日:2017-07-04
申请号:US14569387
申请日:2014-12-12
申请人: Sanofi
发明人: Torsten Haack , Michael Wagner , Bernd Henkel , Siegfried Stengelin , Andreas Evers , Martin Bossart , Dieter Kadereit
IPC分类号: C07K14/575 , C07K14/605 , A61K38/26 , A61K45/06
CPC分类号: A61K38/26 , A61K45/06 , C07K14/57563 , C07K14/605
摘要: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
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公开(公告)号:US20150164996A1
公开(公告)日:2015-06-18
申请号:US14569299
申请日:2014-12-12
申请人: Sanofi
发明人: Dieter Kadereit , Katrin Lorenz , Andreas Evers , Torsten Haack , Michael Wagner , Bernd Henkel , Martin Lorenz , Siegfried Stengelin
IPC分类号: A61K38/26 , A61K45/06 , C07K14/605
CPC分类号: A61K38/26 , A61K45/06 , C07K14/605
摘要: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
摘要翻译: 本发明涉及毒蜥外泌肽-4衍生物及其医疗用途,例如用于治疗代谢综合征疾病,包括糖尿病和肥胖症,以及减少过量的食物摄入。
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公开(公告)号:US11504473B2
公开(公告)日:2022-11-22
申请号:US16763282
申请日:2018-11-15
申请人: SANOFI
发明人: Michael Schabbach , Dieter Kadereit , Andrea Heiberger , Claus Geiger , Charlotte Emma Harvey , Congyi Huang , Timothy Charles Frearson , Alexander David Norman
摘要: A mixing and/or reconstitution system reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time. The system comprises a device containing a first material within a first chamber, a housing, and a plunger, the plunger comprising a second chamber containing a second material, wherein one of the first and the second material is a fluid, and a movable element with an electric, magnetic, or paramagnetic characteristic, wherein the second chamber is initially closed; and a base unit comprising a recess for accommodation of the device, a control unit, and an electromagnetic unit which is adapted to produce an electromagnetic field penetrating the recess, wherein the control unit can electrically operate the electromagnetic unit such that the element contained in the second chamber moves in a direction of the device determined by the electromagnetic field and fluidly communicates the first and second chambers.
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公开(公告)号:US11141489B2
公开(公告)日:2021-10-12
申请号:US16665785
申请日:2019-10-28
申请人: SANOFI
发明人: Dieter Kadereit , Michael Wagner , Thomas Olpp , Nino Meyer , Martin Bossart , Andreas Evers , Peyman Sakhaii , Pradeep K. Dhal , Paul Konowicz , James E. Stefano , Nils Poth
IPC分类号: C07K1/113 , C07K14/605 , A61K47/54 , A61K38/17 , A61K47/61 , A61K47/69 , C07K1/107 , A61P3/04 , A61P3/10 , A61K9/00 , A61K31/728 , A61K38/26 , A61K47/36
摘要: The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon receptor agonist, a linker and a hyaluronic acid hydrogel bearing -L1-L2-L-L-Y—R20 groups, wherein Y represents an GLP-1/Glucagon receptor agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon receptor agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising the conjugate or the pharmaceutically acceptable salt thereof as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon receptor agonist.
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公开(公告)号:US09896434B2
公开(公告)日:2018-02-20
申请号:US15301603
申请日:2015-04-02
申请人: SANOFI
发明人: Lothar Schwink , Christian Buning , Heiner Glombik , Matthias Gossel , Dieter Kadereit , Nis Halland , Matthias Lohmann , Christoph Pöverlein , Kurt Ritter
IPC分类号: C07D401/12 , A61K31/402 , A61K31/4439 , C07D207/26 , A61K45/06 , A61K31/5377 , A61K31/155 , C07D207/273
CPC分类号: C07D401/12 , A61K31/155 , A61K31/402 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D207/26 , C07D207/273 , A61K2300/00
摘要: The present invention relates to indanone compounds. The indanone compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of indanone compounds as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
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