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公开(公告)号：US5972721A
公开(公告)日：1999-10-26
申请号：US816429
申请日：1997-03-14
申请人： John G. Bruno , Johnathan L. Kiel , John P. Kilian
发明人： John G. Bruno , Johnathan L. Kiel , John P. Kilian
CPC分类号： B03C1/032 , B03C1/01 , B03C1/0332 , B03C1/034 , Y10S436/824
摘要： An apparatus and method for immunomagnetic separation and concentration of target biological materials is disclosed. The immunomagnetic separation is performed by a magnetic flow cell, or filter block, as part of an automated mostly continuous immunomagnetic assay system. The magnetic flow cell has two bundles of ferromagnetic rods or pins positioned inside an internal chamber so that a fluid sample flowing through the flow cell passes through the pins. A pair of cobalt magnets flank the flow cell so that the pins concentrate and sufficiently increase the magnetic fields so that even nanometer size magnetic beads can be captured. The overall system combines a reaction subsystem for reacting coated magnetic beads with a sample, a collection subsystem for capturing magnetic beads, a rinsing subsystem for removing debris and a filtering subsystem for removing captured magnetic beads from the collection subsystem. The new magnetic flow filter is the key component for the collection and filtering subsystems.
摘要翻译： 公开了一种用于免疫磁性分离和靶向生物材料浓缩的装置和方法。 免疫磁性分离由磁流量池或过滤块进行，作为自动化大多数连续的免疫磁性测定系统的一部分。 磁流量计具有两束位于内部室内的铁磁棒或销，使得流过流动池的流体样品通过销。 在流动池侧面的一对钴磁体，使得引脚集中并充分增加磁场，使得可以捕获甚至纳米尺寸的磁珠。 整个系统结合了用于使涂覆的磁珠与样品反应的反应子系统，用于捕获磁珠的收集子系统，用于去除碎屑的冲洗子系统和用于从收集子系统中去除捕获的磁珠的过滤子系统。 新的磁流过滤器是收集和过滤子系统的关键组件。
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公开(公告)号：US5876593A
公开(公告)日：1999-03-02
申请号：US931067
申请日：1997-09-15
申请人： Paul A. Liberti , Yuzhou Wang
发明人： Paul A. Liberti , Yuzhou Wang
IPC分类号： B01D35/06 , B03C1/00 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/035 , B03C1/28 , C12M3/00 , G01N33/483 , G01N33/543 , G01N33/569 , G01N35/00 , G01N35/02
CPC分类号： B03C1/002 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/0332 , B03C1/034 , B03C1/035 , C12M47/04 , G01N33/54326 , G01N33/56972 , G01N35/026 , G01N2333/70589 , G01N35/0098 , Y10T436/108331 , Y10T436/25375
摘要： Biological entities such as cells, microbes, or components thereof are labeled with a magnetic colloid containing microscopic magnetic particles. The magnetic particles have a coating capable of biospecific or non-specific binding with the entities. An immobilization apparatus includes a non-magnetic vessel having a ferromagnetic collection structure for attracting the entities toward a collection surface upon which the magnetically labeled entities are immobilized subsequent to placement of the vessel on a support between two magnets. The ferromagnetic collection structure preferably has a sharp edge or high curvature for intensifying the magnetic field and for collecting the entities in a monolayer. The vessel includes an un-obstructed observation path so that immobilized entities may be observed and/or manipulated. The ferromagnetic collection structure may be arranged in various two dimensional patterns to provide a desired collection configuration. The apparatus may further have inlet and outlet ports for allowing a flow of liquid reagent through the vessel for washing or straining the immobilized entities. The support can be translated so that a shoulder on the collection structure concentrates the collected entities by movement of the shoulder in a transverse direction relative to the magnetic field.
摘要翻译： PCT No.PCT / US93 / 11087 Sec。 371日期1995年04月24日 102（e）1995年4月24日PCT PCT 1997年9月15日PCT公布。 公开号WO94 / 11078 日期1994年5月26日生物实体如细胞，微生物或其组分用含有微观磁性颗粒的磁性胶体标记。 磁性颗粒具有能够与实体进行生物特异性或非特异性结合的涂层。 固定装置包括具有铁磁收集结构的非磁性容器，用于在将容器放置在两个磁体之间的支撑件上时，将实体吸引到收集表面，在该收集表面上磁性标记的实体被固定。 铁磁收集结构优选地具有尖锐的边缘或高曲率，用于增强磁场和用于在单层中收集实体。 容器包括未阻挡的观察路径，使得可以观察和/或操纵固定的实体。 铁磁收集结构可以以各种二维图案布置以提供期望的收集配置。 该装置还可以具有用于允许液体试剂流过容器的入口和出口，用于洗涤或使固定的实体变窄。 支撑件可以平移，使得收集结构上的肩部通过肩部相对于磁场的横向方向的移动来集中收集的实体。
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33.发明授权
公开(公告)号：US5786040A
公开(公告)日：1998-07-28
申请号：US626082
申请日：1996-04-01
申请人： Johna Leddy , Sudath Amarasinghe
发明人： Johna Leddy , Sudath Amarasinghe
IPC分类号： B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , C23C6/00 , C23C24/08 , C23C30/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/00 , H01F10/00 , H01F41/24 , H01F41/26 , H01F41/30 , H01M4/02 , H01M4/86 , H01M4/88 , H01M4/90 , H01M4/92 , H01M8/00 , H01M8/04 , H01M8/10 , H01M8/24 , H01M10/42 , B05D1/00
CPC分类号： H01M4/8857 , B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , B82Y25/00 , B82Y40/00 , C23C24/08 , C23C30/00 , C23C6/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/0027 , H01F1/009 , H01F10/007 , H01F41/24 , H01F41/26 , H01F41/301 , H01M10/42 , H01M4/02 , H01M4/86 , H01M4/8605 , H01M4/9083 , H01M4/926 , H01M8/04223 , H01M8/1004 , H01M8/1009 , H01F1/0054 , H01M2300/0082 , H01M4/8882 , H01M8/249 , Y10T428/32
摘要： A method for coating a surface with a magnetic composite material exhibiting distinct flux properties due to gradient interfaces within the composite. Surfaces coated with such a composite can be used to improve fuel cells and to effect improved transport and separation of different species of materials. A wide variety of devices can incorporate such composite-coated surfaces, including separators, fuel cells, electrochemical cells, and electrodes for channeling flux of, or for effecting electrolysis of, magnetic species.
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34.发明授权
公开(公告)号：US4668591A
公开(公告)日：1987-05-26
申请号：US710240
申请日：1985-03-11
CPC分类号： B03C1/034 , B23P17/06 , Y10S428/928 , Y10T428/12424 , Y10T428/12639
摘要： A matrix for magnetic separators which comprises wire or ribbon of a crystalline magnetic alloy having a fine-grained structure and a supersaturated solid solution structure.
摘要翻译： 一种用于磁分离器的基体，其包括具有细晶粒结构和过饱和固溶体结构的结晶磁性合金的线或带。
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公开(公告)号：US4528096A
公开(公告)日：1985-07-09
申请号：US170989
申请日：1980-07-18
申请人： Hans Pfister , Gunter Rupp
发明人： Hans Pfister , Gunter Rupp
摘要： A device for high gradient magnetic separation contains, between two pole pieces, an ordered filter structure with parts of magnetic material, which are arranged perpendicular to the direction of a magnetic field and the flow direction of a medium to be filtered, the filter structure comprising flat ribbons with a thickness of less than 100 .mu.m of a material with a coercitive field strength H.sub.c less than 0.2 Oe, which are arranged so that their axes and the normals of their flat sides are approximately perpendicular to the direction of the magnetic field, requiring only a very small field strength for magnetizing the filter structure in order to obtain high flux density gradients.
摘要翻译： 用于高梯度磁分离的装置在两个极片之间包含具有磁性材料部分的有序滤波器结构，其被布置成垂直于磁场的方向和要被滤波的介质的流动方向，所述滤波器结构包括 厚度小于100μm的具有矫顽场强度Hc小于0.2Oe的材料的扁平带，它们的轴线和它们的平面的法线近似垂直于磁场的方向， 仅需要非常小的场强来磁化滤波器结构以获得高通量密度梯度。
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公开(公告)号：US4460463A
公开(公告)日：1984-07-17
申请号：US458268
申请日：1983-01-17
申请人： Satoshi Yoshida
发明人： Satoshi Yoshida
CPC分类号： B03C1/034
摘要： An electromagnetic filter includes a filtering column filled with a magnetic material and an electromagnetic coil disposed around the filtering column. The magnetic material comprises a plurality of cylindrical, prismatic or plate-like masses of magnetic material placed horizontally in the filtering column so as to form a plurality of layers, each of the masses of magnetic material consisting of a multiplicity of magnetic wires or magnetic tapes bundled so as to have their longitudinal axes arranged in substantially in parallel.The magnetic material filling the filtering column is distributed to a uniform density, so that impairment of the treating effect due to channeling of feed water through sparse portions of the magnetic material and the insufficient washing of dense portions thereof during the cleaning operation for expelling the magnetic particles entrapped in the magnetic material can be avoided. The efficiency of the electromagnetic filter is enhanced because all of the magnetic material filling the filtering column effectively participates in the entrapment of magnetic particles suspended in the feed water.
摘要翻译： 电磁滤波器包括填充有磁性材料的过滤柱和设置在过滤柱周围的电磁线圈。 磁性材料包括多个圆柱形，棱柱形或板状的磁性材料质量的水平放置在过滤柱中以便形成多个层，每个磁性材料块由多根磁线或磁带组成 捆扎成使其纵轴基本上平行布置。 填充过滤柱的磁性材料被分配成均匀的密度，从而在清洁操作期间因给料水通过磁性材料的稀疏部分导致的处理效果的损害以及其致密部分的不充分洗涤而损坏磁性材料 可以避免捕获在磁性材料中的颗粒。 电磁滤波器的效率得到提高，因为填充过滤柱的所有磁性材料有效地参与悬浮在给水中的磁性颗粒的捕获。
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公开(公告)号：US4366065A
公开(公告)日：1982-12-28
申请号：US323698
申请日：1981-11-20
CPC分类号： B01D35/06
摘要： A method and apparatus for separating particles suspended in a liquid from the liquid. A flow of the liquid is passed through a filter bed of ferromagnetic bodies which acts as a coarse filter to trap the larger particles in the flow. The filter bed is arranged within a truncated cone between the poles of an electromagnet. To cleanse the bed and flush out the trapped particles a wash liquid is passed through the bed and the electromagnet is energized to levitate the bed to thereby allow the wash liquid to remove the particles. The liquid flow from the coarse filter can be passed to a high gradient magnetic separator at which remaining small particles in the flow are filtered magnetically.
摘要翻译： 一种从液体中分离悬浮在液体中的颗粒的方法和装置。 液体的流动通过铁磁体的过滤床，其作为粗过滤器以将更大的颗粒捕获在流动中。 过滤床布置在电磁体的极之间的截锥体内。 为了清洁床并冲洗掉被捕获的颗粒，洗涤液体通过床，并且电磁体通电以使床悬浮，从而允许洗涤液体去除颗粒。 来自粗过滤器的液体流可以传递到高梯度磁选机，在该梯度磁选机中流动中剩余的小颗粒被磁力过滤。
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公开(公告)号：US4363729A
公开(公告)日：1982-12-14
申请号：US274991
申请日：1981-06-18
申请人： Junichi Yano
发明人： Junichi Yano
CPC分类号： B03C1/0335
摘要： A magnetic filter for separating ferromagnetic particles from a fluid. The filter includes a filter container having an inlet, outlet, and inner space wherein an annular filter element is located. A magnetic-field generating device is surrounded by the annular filter element, and is adapted to magnetize the filter element. A fluid to be filtered is allowed to enter the filter from the inlet, and ferromagnetic particles in suspension in the fluid, when passing the filter element, are attracted thereby. The purified fluid is allowed to flow out of the filter through the outlet.
摘要翻译： 一种用于从流体中分离铁磁颗粒的磁性过滤器。 过滤器包括具有入口，出口和内部空间的过滤器容器，其中环形过滤器元件被定位。 磁场产生装置被环形过滤元件包围，并适于磁化过滤元件。 允许要过滤的流体从入口进入过滤器，并且当通过过滤元件时悬浮在流体中的铁磁颗粒被吸引。 净化的流体通过出口流出过滤器。
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39.发明授权
公开(公告)号：US4157954A
公开(公告)日：1979-06-12
申请号：US731388
申请日：1976-10-12
申请人： Robin R. Oder
发明人： Robin R. Oder
IPC分类号： B03C1/034
CPC分类号： B03C1/034
摘要： Method for improving production rates during magnetic separation of magnetically attractable particles dispersed in a fluid carrier, as for example during separation of weakly magnetic discoloring contaminants dispersed in a clay slurry. The dispersion is passed through a ferromagnetic filamentatious matrix within a canister disposed in a magnetic field. The matrix is part of a magnetic separator system characterized by a separation parameter p, where p is a function of the geometry and magnetic and electrical properties of the separating apparatus; and of the rheological and magnetic properties of the dispersion. By determinatively adjusting the packing density of the matrix in the canister, and/or by utilizing appropriate solids content in the slurry, production rate is controlled or optimized for a given brightness increase in the clay.
摘要翻译： 在分散在流体载体中的可磁吸引颗粒的磁分离期间提高生产率的方法，例如在分散在粘土浆料中的弱磁性变色污染物的分离期间。 分散体通过设置在磁场中的罐内的铁磁性细丝基质。 该基质是以分离参数p为特征的磁分离器系统的一部分，其中p是分离装置的几何形状和磁性和电学性能的函数; 以及分散体的流变和磁性能。 通过确定性地调节罐中的基质的填充密度和/或通过在浆料中利用适当的固体含量，对粘土中给定的亮度增加来控制或优化生产速率。
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公开(公告)号：US4079002A
公开(公告)日：1978-03-14
申请号：US677129
申请日：1976-04-15
申请人： Joseph Iannicelli
发明人： Joseph Iannicelli
摘要： Magnetic separation apparatus and method is disclosed for removing particles from a fluid-particle mixture, characterized by the provision of a plurality of parallel relatively thin-section matrix separator elements arranged within and parallel to the direction of a magnetic field, and flow establishing means for causing the mixture to flow in parallel flow paths through the matrix elements, respectively, in thickness directions transverse to the direction of the magnetic field. The matrix elements may be parallel spaced polygonal elements, or concentrically arranged annular elements. Preferably the matrix elements include a hollow non-ferromagnetic canister, and a mass of relatively short ferromagnetic fibers having a length of about 1-10 millimeters packed in the canister with a density of at least 8 percent by volume relative to the volume of the canister. Pole pieces may be provided having pole faces with projections thereon for concentrating the magnetic flux longitudinally through the longitudinally arranged matrix elements.
摘要翻译： 公开了用于从流体 - 颗粒混合物中除去颗粒的磁分离装置和方法，其特征在于，在磁场方向上设置并且平行于磁场的多个平行的相对较薄的基体分离器元件，以及流动建立装置， 使得混合物在平行的流动路径中分别沿着横向于磁场方向的厚度方向流过矩阵元件。 矩阵元件可以是平行间隔的多边形元件，或同心布置的环形元件。 优选地，基体元件包括中空非铁磁性罐，以及一批相当短的铁磁纤维，其长度大约为1-10毫米，填充在罐中，其密度相对于罐的体积至少为8体积％ 。 杆件可以设置有具有突起的极面，用于将磁通量纵向集中在纵向排列的矩阵元件上。
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