公开(公告)号：US20170173220A1

公开(公告)日：2017-06-22

申请号：US15440960

申请日：2017-02-23

申请人： Invatec Technology Center GMBH

发明人： Ulrich SPECK ,  Silvio SCHAFFNER ,  Magdalena RENKE-GLUSZKO

IPC分类号： A61L29/16 ,  A61M25/10 ,  A61L29/06

CPC分类号： A61L29/16 ,  A61L29/06 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/63 ,  A61M25/1002 ,  A61M25/1029 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/105 ,  C08L77/00

摘要： The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.

公开(公告)号：US09669134B2

公开(公告)日：2017-06-06

申请号：US13132087

申请日：2009-11-27

申请人： Noel Caplice

发明人： Noel Caplice

IPC分类号： A61F2/06 ,  A61L29/04 ,  A61L29/16

CPC分类号： A61L29/048 ,  A61L29/16 ,  A61L2300/414 ,  A61L2300/602

摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.

公开(公告)号：US20170136155A1

公开(公告)日：2017-05-18

申请号：US15284677

申请日：2016-10-04

申请人： Micell Technologies, Inc.

发明人： James B. McClain ,  Charles Douglas Taylor ,  John Neet

IPC分类号： A61L29/16 ,  A61L29/14 ,  A61L31/08 ,  A61L31/16 ,  A61L29/08 ,  A61L31/10

CPC分类号： A61L29/16 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/20 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/715 ,  A61K38/00 ,  A61L17/005 ,  A61L17/145 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/14 ,  A61L29/148 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  A61M2025/105

摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

公开(公告)号：US09642697B2

公开(公告)日：2017-05-09

申请号：US14396982

申请日：2013-04-24

申请人： SNU R&DB FOUNDATION

发明人： Chan Yeong Heo ,  Young Bin Choy ,  Min Park ,  Su Bin Park ,  Won Seok Lee ,  Byung Hwi Kim

IPC分类号： A61F2/12 ,  A61L27/54

CPC分类号： A61F2/12 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2240/002 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2310/0097 ,  A61L27/54 ,  A61L2300/602 ,  A61L2430/04

摘要： The present invention relates to a breast prosthesis allowing controlled release of a drug and to a production method for same, and more specifically, relates to a breast prosthesis allowing controlled release of a drug by the coupling of a drug layer comprising particles carrying the drug on the breast prosthesis, and to a production method for same.

公开(公告)号：US20170014553A1

公开(公告)日：2017-01-19

申请号：US15125635

申请日：2015-03-13

申请人： W.L GORE & ASSOCIATES, INC.

发明人： Per Antoni ,  Karin LEONTEIN ,  Lars VINCENT ,  Robert L. Cleek ,  Paul D. DRUMHELLER ,  Theresa A. HOLLAND ,  Todd J. JOHNSON ,  Krzysztof R. PIETRZAK ,  Bruce STEINHAUS

IPC分类号： A61L31/16 ,  A61L31/04 ,  A61F2/07 ,  A61L33/04 ,  A61L31/08 ,  A61F2/915 ,  A61L33/00 ,  A61L33/06

CPC分类号： A61L27/54 ,  A61F2/07 ,  A61F2/915 ,  A61F2002/91575 ,  A61K31/337 ,  A61K31/436 ,  A61K31/727 ,  A61K45/06 ,  A61L27/28 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0035 ,  A61L33/0076 ,  A61L33/04 ,  A61L33/064 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/61 ,  A61L2420/02 ,  A61L2420/06 ,  A61K2300/00

摘要： According to the invention there is provided inter alia an implantable medical device with coatings comprising an immobilized heparin moiety and elutable paclitaxel and to methods for making such devices.

摘要翻译： 根据本发明，提供了具有包含固定化肝素部分和可洗脱紫杉醇的包衣的可植入医疗装置以及用于制造这种装置的方法。

公开(公告)号：US20160324817A1

公开(公告)日：2016-11-10

申请号：US15108782

申请日：2014-12-30

申请人： PB&B SA

发明人： Anthony Youri Aho ,  Raghunathan Sandeep

IPC分类号： A61K31/201 ,  A61K31/20 ,  A61K31/375 ,  A61K31/355 ,  A61K38/28 ,  A61L27/54 ,  A61K31/4439 ,  A61K31/57 ,  A61K31/585 ,  A61K31/565 ,  A61K9/00 ,  A61L27/18 ,  A61K9/16 ,  A61K38/18

CPC分类号： A61K31/201 ,  A61K8/11 ,  A61K8/361 ,  A61K8/85 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/5031 ,  A61K31/167 ,  A61K31/192 ,  A61K31/20 ,  A61K31/277 ,  A61K31/352 ,  A61K31/355 ,  A61K31/375 ,  A61K31/405 ,  A61K31/4166 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/522 ,  A61K31/565 ,  A61K31/567 ,  A61K31/57 ,  A61K31/573 ,  A61K31/585 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1875 ,  A61K38/28 ,  A61K38/30 ,  A61K45/06 ,  A61K2800/56 ,  A61K2800/91 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/22 ,  A61L2300/602 ,  A61L2430/34 ,  A61Q19/001 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention is directed to compositions comprising physiologically acceptable, metabolic lipids, and physiologically acceptable, preferably biodegradable controlled release (CR) compounds, wherein the lipids are cell-free and the CR compounds release the metabolic lipids over a delayed time period under physiological conditions. In addition, the present invention relates to the use of such a composition for producing a cosmetic or therapeutic composition, preferably for fat tissue expansion or fat tissue repair. Also, the invention pertains to a method for the therapeutic or cosmetic treatment of a mammal comprising the administration of the composition of the invention and preferably injecting the composition while withdrawing the injection needle until the tissue area of interest is treated.

摘要翻译： 本发明涉及包含生理上可接受的代谢脂质和生理上可接受的，优选可生物降解的控释（CR）化合物的组合物，其中所述脂质是无细胞的，并且CR化合物在生理条件下在延迟的时间段内释放代谢脂质 。 此外，本发明涉及这种组合物在制备化妆品或治疗组合物中的用途，优选用于脂肪组织扩张或脂肪组织修复。 此外，本发明涉及用于治疗或美容治疗哺乳动物的方法，包括施用本发明的组合物，优选在取出注射针的同时注射组合物，直到治疗感兴趣的组织区域。

公开(公告)号：US09474652B2

公开(公告)日：2016-10-25

申请号：US11453524

申请日：2006-06-15

申请人： Jack Mentkow ,  Lisa Mentkow

发明人： Jack Mentkow ,  Lisa Mentkow

IPC分类号： A61B17/08 ,  A61F13/00 ,  A61L15/18 ,  A61L15/24 ,  A61L15/28 ,  A61L15/44

CPC分类号： A61F13/00034 ,  A61F13/00059 ,  A61F13/00063 ,  A61F2013/00153 ,  A61F2013/00472 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00642 ,  A61F2013/00982 ,  A61L15/18 ,  A61L15/24 ,  A61L15/28 ,  A61L15/44 ,  A61L2300/418 ,  A61L2300/602 ,  A61L2400/04 ,  C08L31/04 ,  C08L1/28

摘要： A hemostatic agent delivery system includes a hemostatic agent which is inert and non-reactive yet is capable of forming a stable clot when applied to an actively bleeding wound. The system also includes a delivery assembly to structure to facilitate delivery of the hemostatic agent proximate the hemorrhage site. More specifically, the delivery assembly is structured to releasably contain the hemostatic agent via a release member which is disposed in cooperative relation with a support member which contains the amount of the hemostatic agent. The release member is structured of a soluble material such that it will at least partially dissolve and release the hemostatic agent upon disposition proximate the hemorrhage site. The delivery assembly further comprises a handle member structured to facilitate delivery of the hemostatic agent to the hemorrhage site.

摘要翻译： 止血剂递送系统包括止血剂，其是惰性和非反应性的，但是当应用于积极流血的伤口时能够形成稳定的凝块。 该系统还包括一个输送组件，其结构是便于止血剂在出血部位附近的输送。 更具体地，输送组件被构造成通过与包含止血剂的量的支撑构件配合关系的释放构件可释放地容纳止血剂。 释放构件由可溶性材料构成，使得其将在靠近出血部位处置时至少部分地溶解并释放止血剂。 输送组件还包括构造成便于将止血剂输送到出血部位的手柄部件。

公开(公告)号：US20160287843A1

公开(公告)日：2016-10-06

申请号：US14678966

申请日：2015-04-04

申请人： Douglas Phat Hatran

发明人： Douglas Phat Hatran

IPC分类号： A61M25/10 ,  A61L29/02 ,  A61M37/00 ,  A61K9/00 ,  A61K31/337 ,  A61N1/32 ,  A61L29/16 ,  A61L29/08

CPC分类号： A61M25/104 ,  A61K9/0009 ,  A61K31/337 ,  A61L29/02 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/16 ,  A61M37/00 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/109 ,  A61M2037/0007 ,  A61M2205/0216 ,  A61N1/327

摘要： Active Energy Facilitated Drug Delivery platform for delivering therapeutics to biological tissue through electrical conductivity. This delivery method is comprised of an elastic alloy to encase a balloon or drug deposition, where the alloy acts to emit an electric field in aiding and actively allowing the pharmaceutical agent to have enhanced permeation, binding and internalization to cells and the biological matrix. A therapeutic agent is deposited onto a balloon to embody the drug deposition, reservoir whereby the electrical field facilitates the active transfer of a pharmaceutical agent to the target tissue is described.

摘要翻译： 活性能量促进药物递送平台，通过电导率将治疗剂递送到生物组织。 该递送方法包括用于包裹气球或药物沉积的弹性合金，其中合金用于发出电场以帮助并主动地允许药剂对细胞和生物基质具有增强的渗透，结合和内化。 将治疗剂沉积在气囊上以体现药物沉积，储存器，从而电场促进药剂到目标组织的主动转移。

公开(公告)号：US20160287708A9

公开(公告)日：2016-10-06

申请号：US11561730

申请日：2006-11-20

申请人： Robert John Cottone, JR. ,  Stephen M. Rowland ,  Sherry Parker

发明人： Robert John Cottone, JR. ,  Stephen M. Rowland ,  Sherry Parker

IPC分类号： A61F2/06 ,  C12N5/08

CPC分类号： A61K47/34 ,  A61F2/0077 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K31/436 ,  A61K39/395 ,  A61L27/306 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L29/085 ,  A61L29/106 ,  A61L29/146 ,  A61L29/16 ,  A61L31/047 ,  A61L31/088 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/412 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/06 ,  C12N5/0692 ,  C12N2510/00

摘要： A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

摘要翻译： 提供用于植入体内血管或腔内结构的医疗装置，其刺激正血管重塑。 诸如支架和合成移植物之类的医疗装置涂覆有由控释基质和一种或多种用于将药物直接递送到周围组织的药物物质组成的药物组合物。 医疗装置上的涂层还包含配体，例如肽，抗体或小分子，用于在装置的血液接触表面中捕获祖细胞内皮细胞，用于在损伤部位恢复内皮。 特别地，药物涂层的支架用于例如用于预防或抑制再狭窄的球囊血管成形术程序。

公开(公告)号：US20160263291A1

公开(公告)日：2016-09-15

申请号：US15160999

申请日：2016-05-20

申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.

发明人： O. Mikael TROLLSAS ,  Michael H. NGO ,  David J. SHERMAN ,  Syed F.A, HOSSAINY

IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/33 ,  A61K31/436 ,  A61K31/497 ,  A61K31/56 ,  A61K38/13 ,  A61K38/446 ,  A61K45/06 ,  A61K47/34 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  C08L71/02 ,  C08L67/04

摘要： The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

摘要翻译： 本发明提供具有包含缓慢溶解性聚合物或材料的涂层的可植入装置及其制造和使用方法。