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    METHODS OF TREATING HEPATIC ENCEPHALOPATHY
    36.
    发明申请
    METHODS OF TREATING HEPATIC ENCEPHALOPATHY 有权
    治疗肝硬化病的方法

    公开(公告)号：US20170042864A1

    公开(公告)日：2017-02-16

    申请号：US15212720

    申请日：2016-07-18

    Applicant: Salix Pharmaceuticals, Ltd

    Inventor： William Forbes ,  Kunal Merchant ,  Enoch Bortey ,  Audrey Shaw

    IPC: A61K31/437 ,  A61K31/7016

    CPC classification number: A61K31/437 ,  A61K31/7016 ,  A61K45/06 ,  G06Q50/22 ,  Y02A90/22 ,  A61K2300/00

    Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.

    Abstract translation: 该应用描述了使用胃肠特异性抗生素治疗肝性脑病。 胃肠特异性抗生素的一个例子是利福昔明。 本申请还提供了通过在两个或更多个时间点确定受试者的临界闪烁频率和/或静脉氨水平来确定受试者是否具有神经病症或肝性脑病的方法。 本发明还提供了治疗这些受试者的方法。

    Compositions and methods for reducing oxidative damage
    37.
    发明授权
    Compositions and methods for reducing oxidative damage 有权
    减少氧化损伤的组合物和方法

    公开(公告)号：US09555054B2

    公开(公告)日：2017-01-31

    申请号：US14646660

    申请日：2013-11-21

    Applicant: University of Louisville Research Foundation, Inc.

    Inventor： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

    IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  A61K31/7016 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38 ,  C08L33/14 ,  A61F9/00

    CPC classification number: A61K31/7016 ,  A61F9/00 ,  A61K9/0048 ,  A61K9/0051 ,  A61K47/32 ,  A61K47/38 ,  C08L1/284 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L33/14 ,  C08L2205/05 ,  C08L71/02

    Abstract: Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

    Abstract translation: 提供聚合物组合物，其包括聚（乙二醇），粘弹性聚合物和抗氧化剂，其中聚合形式的组合物具有约1.30至约1.40的折射率。 还提供了合成组合物的方法，包括加热一定量的水的步骤; 向水中加入缓冲剂形成缓冲溶液; 将聚（乙二醇）和粘弹性聚合物混合到缓冲溶液中以形成反应性混合物; 向反应混合物中加入多种抗氧化剂颗粒; 并从反应混合物中除去悬浮气泡。 进一步提供了防止受试者的眼晶状体的氧化损伤的方法，包括将前述聚合物组合物给予受试者的眼晶状体。

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