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    Cardiac event detection over varying time scale
    32.
    发明申请
    Cardiac event detection over varying time scale 有权
    不同时间尺度的心脏事件检测

    公开(公告)号：US20090216141A1

    公开(公告)日：2009-08-27

    申请号：US12320948

    申请日：2009-02-10

    申请人： David R. Fischell ,  Robert E. Fischell ,  Jonathan Harwood ,  Steven R. Johnson

    发明人： David R. Fischell ,  Robert E. Fischell ,  Jonathan Harwood ,  Steven R. Johnson

    IPC分类号： A61B5/0408

    CPC分类号： A61B5/0472 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/413 ,  A61B5/686 ,  A61B5/746 ,  A61N1/025 ,  A61N1/37211 ,  A61N1/37247

    摘要： Disclosed is a “tracker system” that includes implanted electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm means and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes. These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm means to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.

    摘要翻译： 公开了一种“跟踪器系统”，其包括植入的电引线，其是植入式心脏病治疗仪的一部分以及包括外部警报装置和医师程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者的心血管疾病的恶化。 这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，所以跟踪器系统可以通过内部和/或外部报警装置中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。

    Method and Apparatus for Determining Cardiac Performance in a Patient
    33.
    发明申请
    Method and Apparatus for Determining Cardiac Performance in a Patient 审中-公开
    用于确定患者心脏性能的方法和装置

    公开(公告)号：US20090210020A1

    公开(公告)日：2009-08-20

    申请号：US12086040

    申请日：2006-12-14

    申请人： Marc D. Feldman ,  Jonathan W. Valvano ,  John A. Pearce

    发明人： Marc D. Feldman ,  Jonathan W. Valvano ,  John A. Pearce

    IPC分类号： A61N1/368 ,  A61B5/02 ,  A61B5/0215 ,  A61N1/39

    CPC分类号： A61N1/36514 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/413 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/3962 ,  A61N1/3968

    摘要： An apparatus for determining heart transplant rejection of a heart in a patient includes at least two electrodes adapted to be sewn into the heart that span the left ventricle. The apparatus includes a voltage generator adapted to be inserted in the patient which generates a voltage to the two electrodes and senses the resulting voltage from the two electrodes. A method for determining heart transplant rejection of a heart in a patient. A pacemaker for a patient (including bi-ventricular pacing and AICDs). The pacemaker includes an RV lead having four electrodes adapted to be inserted into the RV apex. The pacemaker includes a voltage generator which generates a voltage signal to the electrodes and senses the instantaneous voltage along the length of the RV and determines the real and imaginary components to remove the myocardial components of the septum and RV free wall to determine absolute RV blood volume. The pacemaker includes a battery connected to the voltage generator. The pacemaker includes a defibrillator connected to the battery. The pacemaker can also be a bi-ventricular pacemaker to restore RV and LV synchrony during contraction. A method for assisting a heart of a patient.

    摘要翻译： 用于确定患者心脏移植排斥反应的装置包括至少两个适于被缝合到穿过左心室的心脏中的电极。 该装置包括适于插入到患者体内的电压发生器，该电压产生对两个电极的电压并感测来自两个电极的所得到的电压。 用于确定患者心脏心脏移植排斥反应的方法。 患者的起搏器（包括双心室起搏和AICD）。 起搏器包括RV引线，其具有适于插入RV顶点的四个电极。 起搏器包括电压发生器，其向电极产生电压信号并且感测沿着RV长度的瞬时电压，并且确定实部和虚部分量以去除隔膜和RV游离壁的心肌分量以确定绝对RV血容量 。 起搏器包括连接到电压发生器的电池。 起搏器包括连接到电池的除颤器。 起搏器也可以是一个双心室起搏器，用于在收缩期间恢复RV和LV同步。 一种辅助患者心脏的方法。

    Imaging methods for visualizing implanted living cells
    34.
    发明申请
    Imaging methods for visualizing implanted living cells 审中-公开
    用于可视化植入的活细胞的成像方法

    公开(公告)号：US20090209831A1

    公开(公告)日：2009-08-20

    申请号：US12321139

    申请日：2009-01-15

    申请人： John Kucharczyk ,  Mark A. Litman

    发明人： John Kucharczyk ,  Mark A. Litman

    IPC分类号： A61B5/00 ,  A61B5/055

    CPC分类号： A61B5/055 ,  A61B5/413

    摘要： A method is provided herein for indicating viability of cells grown on a rejection inert tissue cytoarchitecture or scaffolding with a medical device that supports at least one sensing function comprising: non-destructively observing a region of a patient to where cells have been transplanted; guiding the medical device to said region of a patient using the non-destructive observation; positioning said medical device within said region of a patient using the non-destructive observation to assist in the positioning; sensing a property within said region of a patient that is indicative of cell viability or nonviability; and using data from sensing said property within said region to indicate cell viability from a transplant with the region. Magnetic Resonance Imaging is a particularly useful format for non-destructive observation of the region.

    摘要翻译： 本文提供了一种用于指示在具有支持至少一种感测功能的医疗装置的排斥惰性组织细胞结构或脚手架上生长的细胞的活力的方法，包括：非破坏性地观察患者移植细胞的区域; 使用非破坏性观察将医疗装置引导到患者的所述区域; 使用非破坏性观察将所述医疗装置定位在患者的所述区域内以辅助定位; 感测指示细胞活力或不可行性的患者的所述区域内的性质; 以及使用来自所述区域内的所述属性的数据来​​表示来自所述区域的移植的细胞活力。 磁共振成像是对该区域进行非破坏性观察的特别有用的形式。

    Implantable system for monitoring the condition of the heart
    37.
    发明授权
    Implantable system for monitoring the condition of the heart 有权
    用于监测心脏状况的植入式系统

    公开(公告)号：US07512438B2

    公开(公告)日：2009-03-31

    申请号：US10950401

    申请日：2004-09-28

    申请人： David R. Fischell ,  Robert E. Fischell ,  Jonathan Harwood ,  Steven R. Johnson

    发明人： David R. Fischell ,  Robert E. Fischell ,  Jonathan Harwood ,  Steven R. Johnson

    IPC分类号： A61B5/0452

    CPC分类号： A61N1/37235 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/0472 ,  A61B5/413 ,  A61N1/025 ,  A61N1/37247

    摘要： A “tracker system” that includes electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes, These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.

    摘要翻译： “跟踪器系统”包括作为植入式心脏病治疗机的一部分的电引线，以及包括外部警报和医生程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者心血管病症的恶化。这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越狭窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，跟踪器系统可以通过内部和/或外部警报中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。

    Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus
    38.
    发明申请
    Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus 审中-公开
    超声波药物输送和医学诊断成像仪的方法和装置

    公开(公告)号：US20090069678A1

    公开(公告)日：2009-03-12

    申请号：US12087407

    申请日：2007-01-05

    申请人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Takashi Miyake ,  Katsuhiko Fujimoto

    发明人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Takashi Miyake ,  Katsuhiko Fujimoto

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61M37/0092 ,  A61B5/413 ,  A61B5/4839 ,  A61B6/508 ,  A61B8/00

    摘要： According to the present invention, there are provided an ultrasonic drug delivery method and an ultrasonic drug delivery apparatus each capable of performing more localized and efficient drug-delivery with the aid of ultrasonic irradiation under static pressure, which increases the effect of drug delivery to deep tissue parts in treatment by ultrasonic irradiation to a living body for delivery of drugs such as nucleic acids (such as DNA, RNA, decoys, and RNAi), proteins and pharmaceutical compounds, and there is also provided a medical diagnostic imaging apparatus.

    摘要翻译： 根据本发明，提供了一种超声药物输送方法和超声药物输送装置，其能够在静压下借助超声波照射进行更局部有效的药物输送，这增加了药物输送到深度的作用 通过超声波照射到用于输送诸如核酸（例如DNA，RNA，诱饵和RNAi）的药物的生物体的组织部件，蛋白质和药物化合物，并且还提供了医疗诊断成像装置。

    PLATFORM FOR DETECTION OF TISSUE STRUCTURE CHANGE
    40.
    发明申请
    PLATFORM FOR DETECTION OF TISSUE STRUCTURE CHANGE 审中-公开
    用于检测组织结构变化的平台

    公开(公告)号：US20080039718A1

    公开(公告)日：2008-02-14

    申请号：US11837357

    申请日：2007-08-10

    申请人： Darrel Drinan ,  Carl Edman ,  Naresh Bhavaraju

    发明人： Darrel Drinan ,  Carl Edman ,  Naresh Bhavaraju

    IPC分类号： A61B5/055

    CPC分类号： A61B5/05 ,  A61B5/0002 ,  A61B5/0507 ,  A61B5/1075 ,  A61B5/413 ,  A61B8/08

    摘要： Aspects include methods and apparatuses for determining change over time in one or more measured regions of a body using a plurality of data sets obtained by analysis of applied signals to said region. The method may include transmitting and receiving one or more of electromagnetic wave signals, applied acoustic wave signals and electrical signals transmitted through or reflected off of a portion of the measured body region.

    摘要翻译： 方面包括使用通过分析所施加的信号到所述区域获得的多个数据集来确定身体的一个或多个测量区域中随时间变化的方法和装置。 所述方法可以包括发射和接收一个或多个电磁波信号，施加的声波信号以及通过测量的身体区域的一部分透射或反射的电信号。