公开(公告)号：US20180327823A1

公开(公告)日：2018-11-15

申请号：US15769030

申请日：2016-10-27

Applicant: Randox Laboratories Ltd.

Inventor： Stuart Jackson ,  Marin Crockard ,  Stephen Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

IPC: C12Q1/6837 ,  B01L3/00

CPC classification number: C12Q1/6837 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0618 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0887

Abstract: A fluidic card assembly comprising a fluidic card housing (1) and a biochip (3) located in the fluidic card housing. The fluidic card housing (1) includes a chamber (2) with a base wall, into which at least one fluidic channel extends.The biochip (3) is at least partially located in the chamber. A seal (7) is provided for sealing the biochip in the chamber (2) when the biochip is urged into the chamber. The fluidic channel has a serpentine form.

公开(公告)号：US20170128051A1

公开(公告)日：2017-05-11

申请号：US15321112

申请日：2015-06-15

Applicant: Randox Laboratories Ltd.

Inventor： Stuart Jackson ,  Ivan McConnell ,  John Lamont ,  Stephen Peter Fitzgerald

IPC: A61B10/00 ,  A61F5/441

CPC classification number: A61B10/007 ,  A61F5/441

Abstract: A liquid sample collection device is provided. The liquid sample collection device comprises a housing including a liquid collection chamber, and a liquid supply conduit extending from an inlet port and in use generally downwardly to the collection chamber, wherein the collection chamber includes an air vent port located such that in use liquid supplied to the collection chamber through the liquid supply conduit displaces air through the air vent port, and wherein the liquid supply conduit follows a meandering path including at least one air trap section defined at the junction between portions of the conduit extending with upward and downward components respectively, whereby in use once the air vent port is closed, air is displaced along the liquid supply conduit until it is trapped by the air trap section thereby preventing further liquid flow through the conduit.

公开(公告)号：US20170089900A1

公开(公告)日：2017-03-30

申请号：US15304473

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Mark Ruddock ,  Cherith Reid ,  John Lamont ,  Stephen Fitzgerald ,  Ricardo De Matos Simoes ,  Kathleen Williamson

IPC: G01N33/574 ,  G01N33/577 ,  G01N33/543

CPC classification number: G01N33/57407 ,  G01N33/543 ,  G01N33/57488 ,  G01N33/577 ,  G01N33/6869 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/545

Abstract: The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.

公开(公告)号：US20140336283A1

公开(公告)日：2014-11-13

申请号：US14367510

申请日：2012-12-21

Applicant: RANDOX LABORATORIES LTD.

Inventor： Sophie Visvikis-Siest ,  Said El Shamieh ,  Helena Murray ,  John Lamont ,  Peter Fitzgerald

IPC: C12Q1/68

Abstract: The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.

Abstract translation: 本发明描述了与血压相关的基因的单核苷酸多态性之间的上位相互作用，并提供了其在确定个体对高血压易感性的方法中的应用，因此抗高血压治疗是否对所述个体有益。 此外，基因表达水平也与血压相关，也可用于确定对高血压的易感性。