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公开(公告)号:US09250245B2
公开(公告)日:2016-02-02
申请号:US14010889
申请日:2013-08-27
Applicant: GENERAL ELECTRIC COMPANY
Inventor: Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle , Kwok Pong Chan
IPC: G01N33/53 , G01N33/532 , G01N33/533 , G01N21/76 , G01N33/58 , G01N21/64
CPC classification number: G01N33/582 , G01N21/64 , G01N21/6428
Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.
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公开(公告)号:US11919233B2
公开(公告)日:2024-03-05
申请号:US17889852
申请日:2022-08-17
Applicant: General Electric Company
Inventor: Mary Kathryn Thompson , Arunkumar Natarajan , Kwok Pong Chan , Vadim Bromberg , Xi Yang , Ananda Barua , William C. Alberts
IPC: B29C64/165 , B29C64/209 , B29C64/336 , B29K105/00 , B33Y10/00
CPC classification number: B29C64/165 , B29C64/209 , B29C64/336 , B33Y10/00 , B29K2105/0002 , B29K2105/0073 , B29K2995/0082
Abstract: Various embodiments provide a method of additively manufacturing a part including depositing a layer of a powder on a working surface, depositing a binder solution on the layer of the powder at first locations, and depositing a sintering aid solution on the layer of the powder at second locations. The sintering aid solution comprises a sintering aid in a solvent. In various embodiments, the sintering aid enables an increased brown strength as compared to parts containing unbound powder. The method enables binders that provide high green strength to be used at the edges of the part, while also balancing a shortened debind time with an increased brown strength. Embodiments in which binder solution is deposited according to a predetermined pattern at second locations are also described.
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公开(公告)号:US11667078B2
公开(公告)日:2023-06-06
申请号:US17326710
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
IPC: B29C64/165 , B33Y10/00 , B33Y80/00 , B33Y70/10 , B29C64/264 , B29C64/40
CPC classification number: B29C64/165 , B29C64/264 , B29C64/40 , B33Y10/00 , B33Y70/10 , B33Y80/00
Abstract: A method of manufacturing comprises depositing a layer of a powder on a working surface and selectively depositing a water-based binder solution comprising from 0.1 wt % to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C. and less than or equal to 175° C. at 1 atm and a thermoplastic binder comprises a first polymer strand including a first functional group and a second polymer strand including a second functional group into the layer of powder in a pattern representative of a structure of a part. The method further comprises non-covalently coupling the first and second polymer strands together via interaction between the first and second functional groups to form a green body part.
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公开(公告)号:US20210371619A1
公开(公告)日:2021-12-02
申请号:US17326692
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
Abstract: A binder solution comprises greater than or equal to 0.5 wt % and less than or equal to 20 wt % of nanoparticles, a thermoplastic binder, and a solvent. The nanoparticles may comprise metallic nanoparticles comprising nickel, silver, chromium, aluminum, cobalt, iron, or combinations thereof. The nanoparticles may comprise ceramic nanoparticles, the comprising alumina, aluminum nitride, zirconia, titania, silica, silicon nitride, silicon carbide, boron nitride, or combinations thereof. A method of manufacturing a part includes depositing a layer of particulate material on a working surface, applying a binder solution into the layer of particulate material in a pattern, repeating the steps of depositing and selectively applying to form a plurality of layers of particulate material with the applied binder solution, and curing the applied binder solution in the plurality of layers of particulate material with the applied binder solution to evaporate the solvent and thereby form a green body part.
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公开(公告)号:US20210370589A1
公开(公告)日:2021-12-02
申请号:US17326710
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
IPC: B29C64/165 , B29C64/40 , B29C64/264 , B33Y10/00 , B33Y70/10 , B33Y80/00
Abstract: A method of manufacturing comprises depositing a layer of a powder on a working surface and selectively depositing a water-based binder solution comprising from 0.1 wt % to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C. and less than or equal to 175° C. at 1 atm and a thermoplastic binder comprises a first polymer strand including a first functional group and a second polymer strand including a second functional group into the layer of powder in a pattern representative of a structure of a part. The method further comprises non-covalently coupling the first and second polymer strands together via interaction between the first and second functional groups to form a green body part.
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公开(公告)号:US20210370588A1
公开(公告)日:2021-12-02
申请号:US17326707
申请日:2021-05-21
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Joshua Tyler Mook , Kwok Pong Chan , William C. Alberts , Vadim Bromberg
Abstract: A method of manufacturing a green body part comprises depositing a layer of a powder on a working surface; and selectively depositing a binder solution comprising a thermoplastic binder, a fluorescent material, and a binder medium into the layer of powder in a pattern representative of a structure of a layer of the green body part. The thermoplastic binder comprises one or more polymer strands dissolved in a solvent medium having an average molecular weight from greater than or equal to 7,000 g/mol to less than or equal to 100,000 g/mol. Binder solutions comprising fluorescent material and green body parts adhered together using the same are also disclosed.
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公开(公告)号:US10797221B2
公开(公告)日:2020-10-06
申请号:US15441787
申请日:2017-02-24
Applicant: General Electric Company
Inventor: Matthew Harvey Krohn , Sven Runte , Vadim Bromberg , Kwok Pong Chan , Alexander Felix Fiseni , Mihirkumar Pravinbhai Patel
Abstract: Assemblies for an ultrasonic probe and manufacturing methods are presented. In one example, the method includes additively forming first portions of the assembly using a first material with first acoustic properties and second portions of the assembly using a second material with second acoustic properties, the first and second acoustic properties being configured to modify ultrasonic signals of the ultrasonic probe. In another aspect, a housing for an ultrasonic probe is presented. The housing includes additively-formed portions, a fluid channel, and at least one cavity. The first additively-formed portions include a first material with first acoustic properties. The second additively-formed portions include a second material with second acoustic properties. The first and second acoustic properties are configured to modify ultrasonic signals of the ultrasonic probe. The fluid channel is for receiving fluid within the housing of the ultrasonic probe.
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公开(公告)号:US10347818B2
公开(公告)日:2019-07-09
申请号:US15087369
申请日:2016-03-31
Applicant: General Electric Company
Inventor: Douglas Glenn Wildes , Lowell Scott Smith , Kwok Pong Chan , Vadim Bromberg
IPC: H01L41/33 , H01L41/27 , B06B1/06 , H03H3/02 , H01L41/047 , H01L41/09 , H01L41/113 , H01L41/277 , H01L41/29 , H03H9/205 , A61B8/00 , H03H3/04
Abstract: A manufacturing a process is provided for the bulk manufacture of transducer arrays, including arrays having at least one 3D printed (or otherwise additive manufactured) acoustic matching layers. In certain implementations, the manufactured transducers include a composite-piezoelectric transducer on a de-matching layer. In one implementation, by producing multiple arrays at once on a common carrier, and by using direct-deposit additive processes for the matching layers, the described processes greatly reduce the number of parts and the number of manual operations.
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公开(公告)号:US20190054527A1
公开(公告)日:2019-02-21
申请号:US15680733
申请日:2017-08-18
Applicant: General Electric Company
Inventor: Arunkumar Natarajan , Carlos Bonilla Gonzalez , Kwok Pong Chan
Abstract: A method of binder jet printing a part including depositing a layer of a powder on a working surface of a binder jet printer and selectively printing a binder solution having a linkable thermoplastic binder into the layer of the powder in a pattern to generate a printed layer. The pattern is representative of a structure of a layer of the part. The linkable thermoplastic binder includes a first polymer strand and a second polymer strand, the first polymer strand includes a first functional group and the second polymer strand includes a second functional group, and the first and second functional groups non-covalently couple the first polymer strand with the second polymer strand. The method of binder jet printing a part also includes curing the linkable thermoplastic binder in the printed layer to generate a layer of a green body part, heating the green body part above a first temperature to remove at least a portion of the linkable thermoplastic binder and generate a brown body part, and heating the brown body part above a second temperature to sinter the powder to generate the part. The part is substantially free of char residue.
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公开(公告)号:US20180271372A1
公开(公告)日:2018-09-27
申请号:US15897964
申请日:2018-02-15
Applicant: General Electric Company
Inventor: Warren Lee , Eric William Fiveland , David Andrew Shoudy , Timothy Fiorillo , Kwok Pong Chan , Lowell Scott Smith , James Sabatini , David Martin Mills , Thomas Kwok-Fah Foo
CPC classification number: A61B5/0035 , A61B5/055 , A61B5/066 , A61B8/085 , A61B8/4416 , A61B8/4444 , A61B8/5261 , A61B8/5276 , A61B2562/182
Abstract: An ultrasound probe configured for use in a multi-modality imaging system includes a body including one or more electrical components of the ultrasound probe, an outermost housing enclosing the ultrasound probe, and an electromagnetic interference (EMI) shield disposed between the body and the housing, wherein the EMI shield is configured to reduce interference between the ultrasound probe and one or more different imaging systems of the multi-modality imaging system. The ultrasound probe further includes a transducer disposed on a patient-facing surface of the ultrasound probe and a cable coupled to the body and configured to communicatively couple the ultrasound probe to an ultrasound imaging system of the multi-modality imaging system, wherein the ultrasound probe comprises substantially non-ferromagnetic material.
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