Photoactivated chemical bleaching of dyes

    公开(公告)号:US09250245B2

    公开(公告)日:2016-02-02

    申请号:US14010889

    申请日:2013-08-27

    CPC classification number: G01N33/582 G01N21/64 G01N21/6428

    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.

    BINDER SOLUTIONS COMPRISING NANOPARTICLES FOR USE IN ADDITIVE MANUFACTURING

    公开(公告)号:US20210371619A1

    公开(公告)日:2021-12-02

    申请号:US17326692

    申请日:2021-05-21

    Abstract: A binder solution comprises greater than or equal to 0.5 wt % and less than or equal to 20 wt % of nanoparticles, a thermoplastic binder, and a solvent. The nanoparticles may comprise metallic nanoparticles comprising nickel, silver, chromium, aluminum, cobalt, iron, or combinations thereof. The nanoparticles may comprise ceramic nanoparticles, the comprising alumina, aluminum nitride, zirconia, titania, silica, silicon nitride, silicon carbide, boron nitride, or combinations thereof. A method of manufacturing a part includes depositing a layer of particulate material on a working surface, applying a binder solution into the layer of particulate material in a pattern, repeating the steps of depositing and selectively applying to form a plurality of layers of particulate material with the applied binder solution, and curing the applied binder solution in the plurality of layers of particulate material with the applied binder solution to evaporate the solvent and thereby form a green body part.

    Method for manufacturing an assembly for an ultrasonic probe

    公开(公告)号:US10797221B2

    公开(公告)日:2020-10-06

    申请号:US15441787

    申请日:2017-02-24

    Abstract: Assemblies for an ultrasonic probe and manufacturing methods are presented. In one example, the method includes additively forming first portions of the assembly using a first material with first acoustic properties and second portions of the assembly using a second material with second acoustic properties, the first and second acoustic properties being configured to modify ultrasonic signals of the ultrasonic probe. In another aspect, a housing for an ultrasonic probe is presented. The housing includes additively-formed portions, a fluid channel, and at least one cavity. The first additively-formed portions include a first material with first acoustic properties. The second additively-formed portions include a second material with second acoustic properties. The first and second acoustic properties are configured to modify ultrasonic signals of the ultrasonic probe. The fluid channel is for receiving fluid within the housing of the ultrasonic probe.

    THERMOPLASTIC BINDERS FOR USE IN BINDER JETTING ADDITIVE MANUFACTURING

    公开(公告)号:US20190054527A1

    公开(公告)日:2019-02-21

    申请号:US15680733

    申请日:2017-08-18

    Abstract: A method of binder jet printing a part including depositing a layer of a powder on a working surface of a binder jet printer and selectively printing a binder solution having a linkable thermoplastic binder into the layer of the powder in a pattern to generate a printed layer. The pattern is representative of a structure of a layer of the part. The linkable thermoplastic binder includes a first polymer strand and a second polymer strand, the first polymer strand includes a first functional group and the second polymer strand includes a second functional group, and the first and second functional groups non-covalently couple the first polymer strand with the second polymer strand. The method of binder jet printing a part also includes curing the linkable thermoplastic binder in the printed layer to generate a layer of a green body part, heating the green body part above a first temperature to remove at least a portion of the linkable thermoplastic binder and generate a brown body part, and heating the brown body part above a second temperature to sinter the powder to generate the part. The part is substantially free of char residue.

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