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公开(公告)号：US20200069976A1
公开(公告)日：2020-03-05
申请号：US16121223
申请日：2018-09-04
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
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公开(公告)号：US20200054228A1
公开(公告)日：2020-02-20
申请号：US16345974
申请日：2017-10-31
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Cotero , Ying Fan , Tzu-Jen Kao , David Mills , Jeffrey Ashe , Sireesha KAANUMALLE , Kirk Dennis WALLACE , Kenneth Wayne RIGBY , Ileana HANCU , James ROTHMAN
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.
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公开(公告)号：US20170175105A1
公开(公告)日：2017-06-22
申请号：US15453719
申请日：2017-03-08
Applicant: General Electric Company
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
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公开(公告)号：US20160161437A1
公开(公告)日：2016-06-09
申请号：US14559673
申请日：2014-12-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Andrea Jeannine Peters , Thomas Elliot Stecher , Craig Patrick Galligan , Christopher Michael Puleo , Ralf Lenigk
IPC: G01N27/30 , G01N27/453
CPC classification number: G01N27/30 , C12M47/06 , G01N27/453 , H01G9/042 , H01G9/22 , H01G11/02 , H01G11/28 , H01G11/48 , H01G11/86 , H01M4/602 , Y02E60/13
Abstract: The present disclosure relates to the manufacture and use of redox electrodes. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 V.
Abstract translation: 本公开涉及氧化还原电极的制造和使用。 在某些实施方案中，使用混合材料方法制造氧化还原电极，例如使用氧化还原聚合物与载体基底如纤维素纤维或纸的组合。 在某些实施方案中，氧化还原电极适用于大于25V的电压。
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公开(公告)号：US09188113B2
公开(公告)日：2015-11-17
申请号：US14099922
申请日：2013-12-07
Applicant: General Electric Company
CPC classification number: F04B19/006 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0605 , F16K99/0026 , F16K99/0042 , F16K99/0059 , Y10T137/0318 , Y10T436/2575
Abstract: A method of actuating a valve, comprises operatively coupling the valve with an electroosmotic pump; flowing a fluid through the electroosmotic pump; and generating a fluidic pressure of at least 0.75 PSI to actuate the valve, wherein the electroosmotic pump comprises one or more thin, porous, positive electroosmotic membranes and one or more thin porous, negative electroosmotic membranes; a plurality of electrodes comprising cathodes and anodes, and a power source; wherein each of the positive and negative electroosmotic membranes are disposed alternatively and wherein at least one of the cathodes is disposed on one side of one of the membranes and at least one of the anodes is disposed on the other side of the membrane and wherein at least one of the cathodes or anodes is disposed between a positive and a negative electroosmotic membrane.
Abstract translation: 一种致动阀门的方法包括将阀门与电渗泵可操作地连接; 使流体流过电渗泵; 并且产生至少0.75PSI的流体压力来致动所述阀，其中所述电渗泵包括一个或多个薄的，多孔的电渗透膜和一个或多个薄多孔的阴电渗膜; 包括阴极和阳极的多个电极和电源; 其中所述正电渗渗膜和所述阴电渗膜中的每一个交替设置，并且其中至少一个所述阴极设置在所述膜之一的一侧上，并且所述阳极中的至少一个设置在所述膜的另一侧上，并且其中至少 阴极或阳极之一设置在正电沉积膜和负电渗膜之间。
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Patent Agency Ranking
公开(公告)号：US20150233802A1
公开(公告)日：2015-08-20
申请号：US14686876
申请日：2015-04-15
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk
IPC: G01N1/31
CPC classification number: G01N1/312 , A01N1/0242 , A01N1/0284 , B01L3/5023 , B01L3/5088 , B01L7/00 , B01L2200/0678 , B01L2300/0825 , B01L2300/126 , B01L2300/1877 , G01N1/30 , G01N2001/4027 , Y10T436/2525
Abstract: A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
Abstract translation: 提供了一种干燥设置在基板上的生物样品的方法。 该方法包括提供包括样品加载区域和热源的基底; 激活热源产生热量; 将衬底加热至少高于65℃; 并干燥生物样品。 还提供了用于存储样品的装置，其中所述装置包括用于生物样品储存的基底; 以及产生热量以保持至少高于65℃的温度的加热组分。加热组分可以含有一种或多种试剂，其中试剂产生热量以保持至少高于65℃的温度。
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公开(公告)号：US20150027894A1
公开(公告)日：2015-01-29
申请号：US13951929
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nichole Lea Wood , Li Zhu , Craig Patrick Galligan
IPC: B01D57/02
CPC classification number: B01D57/02 , G01N27/4473
Abstract: A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.
Abstract translation: 提供了一种通过电洗脱从生物样品中洗脱生物分子的装置和系统。 用于从生物样品电洗脱生物分子的装置由构造成接收电解质和生物样品的壳体构成，至少两个电极包括可操作地耦合到壳体的导电氧化还原聚合物，以及生物分子不可渗透层，其设置在至少一个 电极。 生物分子不渗透层设置在至少一个电极上以防止生物分子到达电极。 提供了一种系统，其中系统包括样品采集端口，一个或多个包含缓冲液，溶剂，试剂或其组合的储存器，用于电洗脱的装置和控制器。
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公开(公告)号：US11944490B2
公开(公告)日：2024-04-02
申请号：US16517289
申请日：2019-07-19
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , David Andrew Shoudy , Victoria Eugenia Cotero , James Enrico Sabatini
CPC classification number: A61B8/4236 , A61B8/4281 , A61N7/00 , A61N2007/0026
Abstract: Techniques for accurate positioning of an energy application device for neuromodulation treatment protocols are provided. A neuromodulation positioning patch is applied to a patient's skin. The energy application device is coupled to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. The frame is also coupled to a removable dock for an imaging probe. When the frame is coupled to the removable dock the frame of the neuromodulation positioning patch, acquires image data through the opening to identify or verify the treatment position.
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公开(公告)号：US11633630B2
公开(公告)日：2023-04-25
申请号：US16750932
申请日：2020-01-23
Applicant: General Electric Company
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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公开(公告)号：US11235178B2
公开(公告)日：2022-02-01
申请号：US16121223
申请日：2018-09-04
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
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