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公开(公告)号：US09464141B2
公开(公告)日：2016-10-11
申请号：US14418314
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K39/395 , C07K16/30 , C07K16/28 , A61K47/48 , A61K31/551 , A61K45/06 , A61K39/00
CPC classification number: C07K16/3053 , A61K31/551 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K16/2869 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供了包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是吡咯并苯并二氮杂 。
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公开(公告)号：US20160159910A1
公开(公告)日：2016-06-09
申请号：US14851003
申请日：2015-09-11
Applicant: GENENTECH, INC.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K31/5517 , A61K31/706 , G01N33/574 , A61K47/48 , C07K16/22 , A61K51/10 , A61K38/05 , A61K31/404
CPC classification number: C07K16/2827 , A61K31/404 , A61K31/5517 , A61K31/706 , A61K38/05 , A61K47/6803 , A61K47/6809 , A61K47/6855 , A61K47/6869 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/57492
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗B7-H4抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20160017040A1
公开(公告)日：2016-01-21
申请号：US14773334
申请日：2014-03-13
Applicant: GENENTECH, INC.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K47/48 , G01N33/569 , A61K39/395 , A61K51/10 , C07K16/30 , A61K38/08
CPC classification number: C07K16/2827 , A61K38/08 , A61K39/39558 , A61K47/65 , A61K47/6801 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K51/1051 , A61K2039/505 , C07K16/3015 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/56972
Abstract: The disclosure provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本公开提供抗B7-H4抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20150374847A1
公开(公告)日：2015-12-31
申请号：US14705525
申请日：2015-05-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: A61K47/48
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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公开(公告)号：US09175089B2
公开(公告)日：2015-11-03
申请号：US13853620
申请日：2013-03-29
Applicant: GENENTECH INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗LgR5抗体和免疫缀合物及其使用方法。
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Patent Agency Ranking
公开(公告)号：US20150196660A1
公开(公告)日：2015-07-16
申请号：US14418310
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K47/48 , A61K39/395 , C07K16/30
CPC classification number: A61K47/48384 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K2039/505 , A61K2039/507 , C07K16/2869 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是尼莫尿 衍生物。
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公开(公告)号：US20150023871A1
公开(公告)日：2015-01-22
申请号：US14500079
申请日：2014-09-29
Applicant: Genentech, Inc.
Inventor： Paul Polakis , Jyoti Asundi , Ron Firestein , Robert F. Kelley , Krista McCutcheon
CPC classification number: C07K16/30 , A61K31/40 , A61K39/39558 , A61K47/6803 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N33/6854
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20140363873A1
公开(公告)日：2014-12-11
申请号：US14273308
申请日：2014-05-08
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/30
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US08889847B2
公开(公告)日：2014-11-18
申请号：US13766150
申请日：2013-02-13
Applicant: Genentech, Inc.
Inventor： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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公开(公告)号：US08871911B2
公开(公告)日：2014-10-28
申请号：US13963286
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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