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公开(公告)号：US20190241663A1
公开(公告)日：2019-08-08
申请号：US16167000
申请日：2018-10-22
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K47/68 , C07K16/30 , A61K51/10 , G01N33/569 , A61K39/395 , A61K38/08 , A61K47/65
CPC classification number: C07K16/2827 , A61K38/08 , A61K39/39558 , A61K47/65 , A61K47/6801 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K51/1051 , A61K2039/505 , C07K16/3015 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/56972
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20180312602A1
公开(公告)日：2018-11-01
申请号：US15914108
申请日：2018-03-07
Applicant: GENENTECH, INC.
Inventor： Paul Polakis , Youjun Chen
IPC: C07K16/30 , A61K51/10 , A61K39/395 , A61K47/68
CPC classification number: C07K16/303 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K2039/5152 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2319/033
Abstract: The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170240645A1
公开(公告)日：2017-08-24
申请号：US15425527
申请日：2017-02-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: C07K16/30 , A61K31/5383
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09695240B2
公开(公告)日：2017-07-04
申请号：US14528142
申请日：2014-10-30
Applicant: Genentech, Inc.
Inventor： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
CPC classification number: C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
Abstract: The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
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公开(公告)号：US20170058042A1
公开(公告)日：2017-03-02
申请号：US15018710
申请日：2016-02-08
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Ron Firestein , Paul Polakis , Chie Sakanaka , Peter Chang , Rayna Takaki Venook
IPC: C07K16/30 , A61K51/10 , G01N33/574 , A61K47/48
CPC classification number: C07K16/30 , A61K47/6803 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K2317/34 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N33/57492 , G01N2333/705
Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗Ly6E抗体，免疫缀合物及其使用方法。
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Patent Agency Ranking
公开(公告)号：US09463251B2
公开(公告)日：2016-10-11
申请号：US14418310
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K39/395 , A61K47/48 , C07K16/28 , C07K16/30 , A61K39/00
CPC classification number: A61K47/48384 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K2039/505 , A61K2039/507 , C07K16/2869 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是尼莫尿 衍生物。
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公开(公告)号：US20160102146A1
公开(公告)日：2016-04-14
申请号：US14856731
申请日：2015-09-17
Applicant: GENENTECH, INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09290578B2
公开(公告)日：2016-03-22
申请号：US14518294
申请日：2014-10-20
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Ron Firestein , Paul Polakis , Chie Sakanaka , Peter Chang , Rayna Takaki Venook
IPC: C07K16/30 , A61K47/48 , G01N33/574 , A61K39/00
CPC classification number: C07K16/30 , A61K47/6803 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K2317/34 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N33/57492 , G01N2333/705
Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗Ly6E抗体，免疫缀合物及其使用方法。
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公开(公告)号：US09056910B2
公开(公告)日：2015-06-16
申请号：US13873462
申请日：2013-04-30
Applicant: Genentech, Inc.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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10.发明授权公开(公告)号：US08771966B2
公开(公告)日：2014-07-08
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
IPC: G01N33/53
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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