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    PHYSIOLOGICAL METRICS FOR DETERMINING STROKE RISK
    31.
    发明申请
    PHYSIOLOGICAL METRICS FOR DETERMINING STROKE RISK 有权

    公开(公告)号：US20250143650A1

    公开(公告)日：2025-05-08

    申请号：US18934954

    申请日：2024-11-01

    Applicant: California Institute of Technology ,  University of Southern California

    Inventor： Yu Xi Huang ,  Simon Mahler ,  Changhuei Yang ,  Charles Liu

    IPC: A61B5/00 ,  A61B5/026 ,  G16H40/67 ,  G16H50/30

    Abstract: Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.

    Free orientation fourier camera
    33.
    发明授权
    Free orientation fourier camera 有权

    公开(公告)号：US11468557B2

    公开(公告)日：2022-10-11

    申请号：US14658019

    申请日：2015-03-13

    Applicant: California Institute of Technology

    Inventor： Xiaoze Ou ,  Changhuei Yang

    IPC: G06T7/00 ,  G02B27/46 ,  A61B5/00

    Abstract: Certain aspects pertain to Fourier camera systems and methods. In one aspect, a Fourier camera comprises a first optical system, a second optical system, a variable aperture filter, and a light detector. The first optical system configured to receive illumination reflected from a curved sample surface. The variable aperture filter configured to move an aperture to a plurality of aperture locations in a Fourier plane, wherein the aperture filters light from the first optical system to the second optical system. The light detector configured to receive light from the second optical system, and configured to acquire a plurality of raw intensity images of the curved sample surface corresponding to the plurality of aperture locations, wherein the raw images are iteratively updated in overlapping regions in Fourier space to generate a focused, substantially uniform resolution image of the curved sample surface, and wherein the overlapping regions correspond to the plurality of aperture locations.

    Array level Fourier ptychographic imaging
    35.
    发明授权
    Array level Fourier ptychographic imaging 有权

    公开(公告)号：US10732396B2

    公开(公告)日：2020-08-04

    申请号：US16242934

    申请日：2019-01-08

    Applicant: California Institute of Technology

    Inventor： Jinho Kim ,  Changhuei Yang

    IPC: G02B21/36 ,  G02B21/16 ,  G02B21/00 ,  G01N21/64 ,  G02B13/00 ,  H04N5/225

    Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.

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