公开(公告)号：US20210000818A1

公开(公告)日：2021-01-07

申请号：US16913404

申请日：2020-06-26

Applicant: Alkermes Pharma Ireland Limited

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: A61K31/485 ,  C07D211/62 ,  C07D217/04 ,  C07D221/22 ,  C07D221/28 ,  C07D223/04 ,  C07D401/12 ,  C07D405/12 ,  C07D489/00 ,  C07D489/09

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.

公开(公告)号：US10807995B2

公开(公告)日：2020-10-20

申请号：US16508697

申请日：2019-07-11

Applicant: Alkermes Pharma Ireland Limited

Inventor： Brian M. Aquila ,  Hoan Huynh ,  Lewis D. Pennington ,  Ingo Mugge ,  Baudouin Gerard ,  Markus Haeberlein ,  Roman A. Valiulin ,  Julius F. Remenar ,  Demetri T. Moustakas ,  Thomas Andrew Wynn ,  Todd Bosanac

IPC: C07D519/00 ,  A61K9/00

Abstract: The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

公开(公告)号：US20200016151A1

公开(公告)日：2020-01-16

申请号：US16508703

申请日：2019-07-11

Applicant: Alkermes Pharma Ireland Limited

Inventor： Brian M. Aquila ,  Hoan Huynh ,  Lewis D. Pennington ,  Ingo Mugge ,  Baudouin Gerard ,  Markus Haeberlein ,  Roman A. Valiulin ,  Julius F. Remenar ,  Demetri T. Moustakas ,  Thomas Andrew Wynn ,  Todd Bosanac

IPC: A61K31/485 ,  A61K9/00 ,  A61K47/55 ,  A61K47/54

Abstract: The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

公开(公告)号：US10406133B2

公开(公告)日：2019-09-10

申请号：US16145703

申请日：2018-09-28

Applicant: Alkermes Pharma Ireland Limited

Inventor： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC: C07C229/30 ,  A61K31/225 ,  C07D491/113 ,  C07D211/06 ,  C07D207/40 ,  C07D295/088 ,  C07D211/38 ,  C07D209/52 ,  C07C317/18 ,  C07D207/06 ,  C07C233/91 ,  C07C233/18 ,  C07C229/16 ,  C07C219/08 ,  C07C317/28

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

公开(公告)号：US20190218185A1

公开(公告)日：2019-07-18

申请号：US16363465

申请日：2019-03-25

Applicant: Alkermes Pharma Ireland Limited

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: C07D221/28 ,  C07D489/00 ,  A61K31/485 ,  C07D221/26 ,  C07D405/06

Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.

公开(公告)号：US10301256B2

公开(公告)日：2019-05-28

申请号：US15363610

申请日：2016-11-29

Applicant: Alkermes Pharma Ireland Limited

Inventor： Thomas Andrew Wynn ,  Christopher P. Hencken

IPC: C07D275/06 ,  C07D275/02 ,  C07C311/06 ,  C07C311/29 ,  C07C311/48 ,  C07C313/06 ,  C07C311/04 ,  C07C311/09 ,  C07C311/17

Abstract: The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis.

公开(公告)号：US10080733B2

公开(公告)日：2018-09-25

申请号：US15782128

申请日：2017-10-12

Applicant: Alkermes Pharma Ireland Limited

Inventor： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC: C07D491/113 ,  A61K31/225 ,  C07C317/28 ,  C07D211/38 ,  C07D295/088 ,  C07D207/40 ,  C07D211/06 ,  C07D207/06 ,  C07D209/52 ,  C07C317/18 ,  C07C219/08 ,  C07C229/16 ,  C07C233/18 ,  C07C233/91

CPC classification number: A61K31/225 ,  C07C219/08 ,  C07C229/16 ,  C07C233/18 ,  C07C233/91 ,  C07C317/18 ,  C07C317/28 ,  C07D207/06 ,  C07D207/40 ,  C07D209/52 ,  C07D211/06 ,  C07D211/38 ,  C07D295/088 ,  C07D491/113

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

公开(公告)号：US20180016237A1

公开(公告)日：2018-01-18

申请号：US15595013

申请日：2017-05-15

Applicant: Alkermes Pharma Ireland Limited

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: C07D221/28 ,  C07D405/06 ,  C07D221/26 ,  C07D489/00 ,  A61K31/485

CPC classification number: C07D221/28 ,  A61K31/485 ,  C07D221/26 ,  C07D405/06 ,  C07D489/00

Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.

公开(公告)号：US09682936B2

公开(公告)日：2017-06-20

申请号：US15216061

申请日：2016-07-21

Applicant: ALKERMES PHARMA IRELAND LIMITED

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: A61K31/439 ,  C07D221/22 ,  C07D221/28 ,  C07D221/26 ,  C07D405/06 ,  A61K31/485 ,  C07D489/00

CPC classification number: C07D221/28 ,  A61K31/485 ,  C07D221/26 ,  C07D405/06 ,  C07D489/00

Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.

公开(公告)号：US09505776B2

公开(公告)日：2016-11-29

申请号：US14212745

申请日：2014-03-14

Applicant: Alkermes Pharma Ireland Limited

Inventor： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC: C07D491/113 ,  C07C317/28 ,  C07D211/38 ,  C07D295/088 ,  C07D207/40 ,  C07D211/06 ,  C07D207/06 ,  C07D209/52 ,  C07C317/18 ,  C07C219/08 ,  C07C229/16 ,  C07C233/18 ,  C07C233/91

CPC classification number: A61K31/225 ,  C07C219/08 ,  C07C229/16 ,  C07C233/18 ,  C07C233/91 ,  C07C317/18 ,  C07C317/28 ,  C07D207/06 ,  C07D207/40 ,  C07D209/52 ,  C07D211/06 ,  C07D211/38 ,  C07D295/088 ,  C07D491/113

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.