公开(公告)号：US20170124284A1

公开(公告)日：2017-05-04

申请号：US15315817

申请日：2015-06-03

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ferry Tamtoro ,  Huaying Yang ,  Mark Ka Lai Lee ,  Desheng Yin ,  Scott R. Gibson ,  Donald Busby ,  Peter V. Shultz ,  Keith P. Kogler ,  Jimmie L. Ward ,  Christopher R. Folk ,  Steven William Badelt

IPC: G06F19/00 ,  A61M5/24 ,  A61M5/32 ,  A61M5/20 ,  A61M5/142 ,  A61M5/158

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient. The drug delivery system may further include one or more sensors coupled to the drug delivery device, a wireless transmitter, and a controller coupled to the one or more sensors and the wireless transmitter. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device, and control the wireless transmitter to wirelessly transmit one or more reports representative of the condition or the operational state of the drug delivery device. A method for use with a drug delivery device is also disclosed.

公开(公告)号：US20170119969A1

公开(公告)日：2017-05-04

申请号：US15315829

申请日：2015-06-03

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ferry Tamtoro ,  Huaying Yang ,  Mark Ka LAi Lee ,  Desheng Yin ,  Scott R. Gibson ,  Donald Busby ,  Peter V. Shultz ,  Keith P. Kogler ,  Basel Hasan Taha ,  Jimmie L. Ward ,  Christopher R. Folk ,  Steven William Badelt

IPC: A61M5/20 ,  A61M5/32 ,  G06F19/00 ,  A61M5/315

CPC classification number: A61M5/20 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/24 ,  A61M5/31501 ,  A61M5/31568 ,  A61M5/3202 ,  A61M5/3243 ,  A61M5/3257 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/3267 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/3553 ,  A61M2205/3576 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/6009 ,  G06F19/325 ,  G06F19/3418 ,  G06F19/3468 ,  G06Q50/01 ,  G06Q50/22

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed.

公开(公告)号：US20160175527A1

公开(公告)日：2016-06-23

申请号：US15040361

申请日：2016-02-10

Applicant: AMGEN INC.

Inventor： Adam B. McCullough

IPC: A61M5/20 ,  A61M5/50

CPC classification number: A61M5/14244 ,  A61M5/00 ,  A61M5/14248 ,  A61M5/14526 ,  A61M5/1454 ,  A61M5/1684 ,  A61M5/16881 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/31501 ,  A61M5/5086 ,  A61M2005/14252 ,  A61M2005/1581 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2205/13 ,  A61M2205/33 ,  A61M2205/3351 ,  A61M2205/50 ,  A61M2205/583 ,  A61M2205/8225

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

公开(公告)号：US20240325645A1

公开(公告)日：2024-10-03

申请号：US18743332

申请日：2024-06-14

Applicant: AMGEN INC.

Inventor： Matias MELANDER ,  Jakob Halkjaer PEDERSEN ,  Christian PLAMBECH ,  Adam B. McCullough ,  Julian JAZAYERI

IPC: A61M5/24 ,  A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/24 ,  A61M5/3129 ,  A61M5/3148 ,  A61M5/2033 ,  A61M2005/208 ,  A61M2005/2086 ,  A61M2005/3143 ,  A61M5/31585 ,  A61M2005/3267

Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.

公开(公告)号：US20240238529A1

公开(公告)日：2024-07-18

申请号：US18409480

申请日：2024-01-10

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ronald Forster ,  Joseph Michael Iglesias ,  Matias Melander ,  Rasmus Øhlenschlæger ,  Christian Plambech ,  Lars Stenholt ,  Bjarke Lykke Ludvig Svendsen

IPC: A61M5/31 ,  A61M5/20 ,  A61M5/315

CPC classification number: A61M5/3145 ,  A61M5/20 ,  A61M5/31583 ,  A61M2005/3143

Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.

公开(公告)号：US20230138654A1

公开(公告)日：2023-05-04

申请号：US16609466

申请日：2018-06-04

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ronald Forster ,  Joseph Michael Iglesias ,  Matias Melander ,  Rasmus Øhelschlaeger ,  Christian Plambech ,  Lars Stenholt ,  Bjarke Lykke Ludvig Svendsen

IPC: A61M5/31 ,  A61M5/20

Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.

公开(公告)号：US20230098606A1

公开(公告)日：2023-03-30

申请号：US17940422

申请日：2022-09-08

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Basel Hasan Taha ,  Jimmie L. Ward ,  Steven William Badelt ,  Ferry Tamtoro ,  Huaying Yang ,  Mark Ka Lai Lee ,  Desheng Yin ,  Scott R. Gibson ,  Donald Busby ,  Peter V. Shultz ,  Keith P. Kogler

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32 ,  A61M5/142 ,  A61M5/50 ,  G16H20/17 ,  G16H40/63 ,  G16H40/00 ,  G16H40/67 ,  G06Q50/22 ,  G06Q50/00 ,  A61M5/158 ,  A61M5/24

Abstract: Devices and methods are disclosed for assisting a user of a drug delivery device with an application executing on a mobile computing device. The mobile computing device may receive information from the drug delivery device related to its condition and/or operation and subsequently select an informational and/or instructional prompt to be displayed to the user based on the received information. The mobile computing device may also generate a display in the application including the selected informational prompt and/or the instructional prompt. Accordingly, the user of the drug delivery device can be guided through the drug delivery process in real time, thereby reducing the likelihood of improper or incomplete use of the drug delivery device.

公开(公告)号：US20220257862A1

公开(公告)日：2022-08-18

申请号：US17534173

申请日：2021-11-23

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ferry Tamtoro ,  Huaying Yang ,  Mark Ka Lai Lee ,  Desheng Yin ,  Scott R. Gibson ,  Donald Busby ,  Peter V. Shultz ,  Keith P. Kogler ,  Basel Hasan Taha ,  Jimmie L. Ward ,  Christopher R. Folk ,  Steven William Badelt

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32 ,  A61M5/142 ,  A61M5/50 ,  G16H20/17 ,  G16H40/63 ,  G16H40/00 ,  G16H40/67 ,  G06Q50/22 ,  G06Q50/00 ,  A61M5/158 ,  A61M5/24

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed.

公开(公告)号：US11351308B2

公开(公告)日：2022-06-07

申请号：US15775630

申请日：2016-12-09

Applicant: AMGEN INC.

Inventor： Huaying Yang ,  Desheng Yin ,  Ferry Tamtoro ,  Scott Robert Gibson ,  Keith P. Kogler ,  Michael Friedman ,  Neal Johnston ,  Adam B. McCullough

IPC: A61M5/32 ,  A61M5/50 ,  G16H40/67 ,  G16H20/17 ,  A61K39/00 ,  A61M5/24 ,  C07K16/00 ,  C07K14/52 ,  C07K14/535 ,  A61M5/14 ,  C07K14/47 ,  A61M5/31 ,  G16H40/63 ,  A61M5/44 ,  A61K38/17 ,  A61K38/19 ,  A61M5/20 ,  C07K14/705 ,  C07K16/28 ,  C07K16/40

Abstract: A drug delivery device includes a housing defining a shell, a drug delivery assembly at least partially disposed within the housing, a cap defining an opening and being adapted to at least partially cover an end of the housing, at least one electronic component, a power source which powers the at least one electronic component, and a switch assembly. The drug delivery assembly comprises a guard which engages an inner surface of the housing and is movable between a first position, a second position, and a third position relative to the housing and is adapted to restrict external contact with a cannula. The switch assembly causes the power source to provide power to the at least one electronic component when the cap is removed from the housing, restrict the power source from providing power when the cap is coupled to the housing and the guard is in the first position, and cause the power source to provide power when the cap is coupled to the housing and the guard is in the third position.

公开(公告)号：US20220096747A1

公开(公告)日：2022-03-31

申请号：US17426194

申请日：2020-02-11

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Paul Daniel Faucher ,  Antonio S. Murcia ,  Nathan Thomas Balcom ,  William Wistar Rhoads ,  Nicholas D.M. Prsha

IPC: A61M5/168 ,  A61M5/36 ,  A61M5/145 ,  A61M39/22

Abstract: A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material that exerts an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container or the supply line and includes a digital controller, a fluid valve operably coupled to the digital controller, and a diaphragm assembly in fluid communication with the fluid valve and operably coupled to the digital controller. The fluid valve, the diaphragm assembly, and the digital controller cooperate to regulate a flow rate of the drug.