公开(公告)号：US20250050026A1

公开(公告)日：2025-02-13

申请号：US18931635

申请日：2024-10-30

Applicant: AMGEN INC.

Inventor： Christian PLAMBECH ,  Matias MELANDER

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32

Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

公开(公告)号：US20210338936A1

公开(公告)日：2021-11-04

申请号：US17273663

申请日：2019-10-04

Applicant: AMGEN INC.

Inventor： Jakob Halkjaer PEDERSEN ,  Matias MELANDER

IPC: A61M5/315 ,  A61M5/20

Abstract: A drug delivery device includes a housing defining a shell having a proximal end and a distal end and a longitudinal axis extending between the proximal end and the distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing and operably coupled to the needle assembly, and an audible indicator operably coupled to the drive assembly. The needle assembly includes a syringe containing a medicament and a needle or a cannula. The drive assembly is movable between an initial position and a second position that results in the medicament being expelled from the syringe. Upon the drive assembly being positioned in the second position, the audible indicator engages the drive assembly to generate an audible sound indicating the medicament has been expelled from the syringe.

公开(公告)号：US20240374825A1

公开(公告)日：2024-11-14

申请号：US18660595

申请日：2024-05-10

Applicant: AMGEN INC.

Inventor： Christian PLAMBECH ,  Matias MELANDER ,  Knud Hellek FINKEN ,  Martin Nissen ENEMARK

IPC: A61M5/20

Abstract: A damper mechanism for a drug delivery device comprising a frame member, a damper member operably coupled to a drive assembly of the drug delivery device, a damper fluid chamber formed between at least a portion of the frame member and the damper member, and a damper fluid disposed within the damper fluid chamber. The frame member and the damper member rotate relative to each other, and the damper fluid exerts an opposing force on at least one of the frame member and the damper member. The damper fluid chamber includes a main section and an overfill section. The overfill section receives excess damper fluid from the main section to reduce an effect a variation in fill level in the damper fluid chamber has on the opposing force exerted on at least one of the frame member or the damper member.

公开(公告)号：US20240325645A1

公开(公告)日：2024-10-03

申请号：US18743332

申请日：2024-06-14

Applicant: AMGEN INC.

Inventor： Matias MELANDER ,  Jakob Halkjaer PEDERSEN ,  Christian PLAMBECH ,  Adam B. McCullough ,  Julian JAZAYERI

IPC: A61M5/24 ,  A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/24 ,  A61M5/3129 ,  A61M5/3148 ,  A61M5/2033 ,  A61M2005/208 ,  A61M2005/2086 ,  A61M2005/3143 ,  A61M5/31585 ,  A61M2005/3267

Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.

公开(公告)号：US20240100258A1

公开(公告)日：2024-03-28

申请号：US18534155

申请日：2023-12-08

Applicant: AMGEN INC.

Inventor： Emil FINKELSTEIN ,  Soren Forbech SKALL ,  Lars EILERTSEN ,  Matias MELANDER ,  Jan JENSEN

IPC: A61M5/315

CPC classification number: A61M5/31536 ,  A61M5/20

Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.