公开(公告)号：US20250050026A1

公开(公告)日：2025-02-13

申请号：US18931635

申请日：2024-10-30

Applicant: AMGEN INC.

Inventor： Christian PLAMBECH ,  Matias MELANDER

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32

Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

公开(公告)号：US20240374825A1

公开(公告)日：2024-11-14

申请号：US18660595

申请日：2024-05-10

Applicant: AMGEN INC.

Inventor： Christian PLAMBECH ,  Matias MELANDER ,  Knud Hellek FINKEN ,  Martin Nissen ENEMARK

IPC: A61M5/20

Abstract: A damper mechanism for a drug delivery device comprising a frame member, a damper member operably coupled to a drive assembly of the drug delivery device, a damper fluid chamber formed between at least a portion of the frame member and the damper member, and a damper fluid disposed within the damper fluid chamber. The frame member and the damper member rotate relative to each other, and the damper fluid exerts an opposing force on at least one of the frame member and the damper member. The damper fluid chamber includes a main section and an overfill section. The overfill section receives excess damper fluid from the main section to reduce an effect a variation in fill level in the damper fluid chamber has on the opposing force exerted on at least one of the frame member or the damper member.

公开(公告)号：US20240325645A1

公开(公告)日：2024-10-03

申请号：US18743332

申请日：2024-06-14

Applicant: AMGEN INC.

Inventor： Matias MELANDER ,  Jakob Halkjaer PEDERSEN ,  Christian PLAMBECH ,  Adam B. McCullough ,  Julian JAZAYERI

IPC: A61M5/24 ,  A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/24 ,  A61M5/3129 ,  A61M5/3148 ,  A61M5/2033 ,  A61M2005/208 ,  A61M2005/2086 ,  A61M2005/3143 ,  A61M5/31585 ,  A61M2005/3267

Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.