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公开(公告)号:US20220193685A1
公开(公告)日:2022-06-23
申请号:US17602897
申请日:2020-04-08
Applicant: RANDOX LABORATORIES LTD
Inventor: Proinnsias McGleenan , P Evans , Stuart Jackson , Martin Reid , Peter Fitzgerald
IPC: B01L9/00
Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.
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公开(公告)号:US10416175B2
公开(公告)日:2019-09-17
申请号:US15385063
申请日:2016-12-20
Applicant: Randox Laboratories Limited
Inventor: Ivan McConnell , Elouard Benchikh , Philip Lowry , Peter Fitzgerald
IPC: G01N33/94 , C07K16/44 , G01N33/543
Abstract: An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.
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公开(公告)号:US10253006B2
公开(公告)日:2019-04-09
申请号:US15130137
申请日:2016-04-15
Applicant: RANDOX LABORATORIES LIMITED
Inventor: Elouard Benchikh , Ivan McConnell , Philip Lowry , Peter Fitzgerald
IPC: C07D295/155 , G01N33/53 , C07K14/47 , C07K14/765 , C07K16/44 , C07D295/096 , C07D241/04
Abstract: The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity.
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公开(公告)号:US10209167B2
公开(公告)日:2019-02-19
申请号:US15036811
申请日:2014-11-13
Applicant: Randox Laboratories Ltd.
Inventor: Michael Veitinger , Maria Zellner
Abstract: The present invention provides a novel method of in vitro sample preparation for the analysis of proteins. In a first aspect, the present invention is a method comprising the separation and individual treatment of blood platelets and platelet-poor plasma obtained from a platelet-rich plasma sample. This allows for optimal treatment of both fractions and overcomes many of the problems associated with current methods. In a second aspect of the present invention the platelet sample preparation method can be implemented before a biochip based immunoassay for the detection of platelet proteins in combination with plasma proteins.
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公开(公告)号:US20180237380A1
公开(公告)日:2018-08-23
申请号:US15903361
申请日:2018-02-23
Applicant: Randox Laboratories Ltd.
Inventor: Ivan McCONNELL , Peter FITZGERALD , Elouard BENCHIKH , Philip LOWRY
IPC: C07C233/79 , C07K16/18 , G01N33/94
CPC classification number: C07C233/79 , C07K16/16 , C07K16/18 , C07K16/44 , C07K2317/33 , G01N33/5308 , G01N33/9486
Abstract: Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[2-(dimethylamino)cylohexyl]-N-methylbenzamide and 3,4,-dichloro-N-[2-(methylamino)cylohexyl]-N-methylbenzamide, as well as the precursory immunogens, are described.
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公开(公告)号:USD815752S1
公开(公告)日:2018-04-17
申请号:US29510481
申请日:2014-11-28
Applicant: Randox Laboratories Ltd.
Designer: Stuart Jackson , Ivan McConnell , John Lamont , Peter Fitzgerald
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公开(公告)号:US20180011115A1
公开(公告)日:2018-01-11
申请号:US15547608
申请日:2016-01-29
Applicant: Randox Laboratories Ltd.
Inventor: Mark W. Ruddock , Cherith N. Reid , Kate E. Williamson , John Lamont , Peter Fitzgerald
IPC: G01N33/86
CPC classification number: G01N33/86 , G01N33/57407 , G01N33/6893 , G01N2800/50 , G01N2800/709
Abstract: The present invention related to a method for detecting a history of exposure to a chemical(s) comprising measuring the concentration of thrombomodulin in a sample isolated from a subject, and determining whether the concentration of thrombomodulin is altered compared to control reference levels.
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公开(公告)号:US20170343570A1
公开(公告)日:2017-11-30
申请号:US15610199
申请日:2017-05-31
Applicant: RANDOX LABORATORIES LTD.
Inventor: ELOUARD BENCHIKH , IVAN MCCONNELL , PHILIP LOWRY , PETER FITZGERALD
IPC: G01N33/94 , C07K16/06 , C07D333/32 , C07D295/096 , C07K14/765 , C07K14/47 , C12N9/08 , C07K16/44
CPC classification number: G01N33/9486 , A61K39/0013 , A61K39/385 , A61K2039/6031 , A61K2039/6081 , C07D295/096 , C07D333/32 , C07K14/47 , C07K14/765 , C07K16/06 , C07K16/44 , C07K2317/33 , C12N9/0065 , C12Y111/01007
Abstract: Components for enabling immunodection of MT-45 are described including immunogens, antibodies derived from the immunogens, immunoassay methods, detecting agents and kits.
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公开(公告)号:US20170225160A1
公开(公告)日:2017-08-10
申请号:US15519096
申请日:2015-10-15
Applicant: Randox Laboratories Ltd.
Inventor: Stuart Jackson , Martin Crockard , Steve Haswell
CPC classification number: B01L3/5027 , B01L3/5023 , B01L3/502738 , B01L2300/0887 , B01L2400/0644 , F16K99/0001 , F16K99/0013 , F16K2099/0084
Abstract: According to the invention there is a microfluidic chip 1 that includes at least two layers 10 forming a stack of layers, each layer of which has at least one flow channel 14; a bore 16 extending through the layers and communicating with a plurality of flow channels; and a valve 20, which has a shaft 22 with a recess 222 in a side of the shaft for fluid to flow through. The shaft is rotatably mounted in the bore, and has a first position in which the recess is aligned with each of at least two flow channels of the plurality of flow channels thereby providing a flow path between said at least two flow channels, and a second position in which the recess is unaligned with at least one of said at least two flow channels the flow path between said at least two flow channels thereby being closed. This allows a fluid flow path between two flow channels to be open and closed by rotation of the shaft so that fluid in the microfluidic chip can be redirected to allow the chip to have greater capability and by using a minimal amount of space on the chip to do so.
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公开(公告)号:US20160084859A1
公开(公告)日:2016-03-24
申请号:US14859948
申请日:2015-09-21
Applicant: Randox Laboratories Limited
Inventor: Ivan McConnell , Peter Fitzgerald , Phillip Lowry , Elouard Benchikh
IPC: G01N33/94 , C07K16/44 , C07D409/12 , C07D231/56
CPC classification number: G01N33/948 , C07D231/56 , C07D409/12 , C07K16/44
Abstract: Components for enabling immunodection of indazole synthetic cannabinoids are described including immunogens, haptens, antibodies, methods and kits.
Abstract translation: 描述了用于实现吲唑合成大麻素的免疫测定的组分,包括免疫原,半抗原,抗体,方法和试剂盒。
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