HIGH SHEAR APPLICATION IN DRUG DELIVERY
    33.
    发明申请
    HIGH SHEAR APPLICATION IN DRUG DELIVERY 审中-公开
    药物递送中的高剪切应用

    公开(公告)号:US20140066852A1

    公开(公告)日:2014-03-06

    申请号:US14075105

    申请日:2013-11-08

    Abstract: In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.

    Abstract translation: 在本公开中,公开了利用高剪切的药物递送的方法和系统。 在一个实施方案中,一种方法包括(1)使含有药物的治疗流体经受高剪切; 和(2)获得加工的治疗液,其中所述经处理的治疗液含有纳米尺寸的药物。 在一个实施方案中,一种方法包括(1)使药物载体和含有药物的治疗液体经受高剪切; 和(2)获得加工的治疗流体,其中所述经处理的治疗液含有载有药物的药物载体。 在一个实施方案中,一种方法包括(1)对药物载体和含有药物的治疗液施加高剪切力; (2)获得经处理的治疗液,其中所述经处理的治疗液含有载药载体; 和(3)用靶向部分修饰载有药物的载体以获得修饰的药物载体。

    METHOD OF HIGH SHEAR COMMINUTION OF SOLIDS
    39.
    发明申请
    METHOD OF HIGH SHEAR COMMINUTION OF SOLIDS 有权
    固体高剪切方法

    公开(公告)号:US20140209714A1

    公开(公告)日:2014-07-31

    申请号:US13790733

    申请日:2013-03-08

    CPC classification number: B02C23/08 B02C23/18 C10G1/045 C10G31/08

    Abstract: Herein disclosed in a method comprising: shearing a feed comprising a solid component in a high shear device to produce a product, at least a portion of which comprises sheared solids; and separating at least some of the sheared solids from the product to produce a component-reduced product, wherein the solid component in the feed stream comprises a first particle density, and wherein the sheared solids in the product comprise a second particle density greater than the first particle density. In some embodiments, the solid component of the feed comprises gas trapped therein, and wherein at least a portion of said gas is released from the solid component upon shearing. Herein also is disclosed a method of comminuting solids in a feed stream comprising a solid component by processing the feed stream in a high shear device to produce a product stream comprising comminuted solids.

    Abstract translation: 本文公开的方法包括:在高剪切装置中剪切包含固体组分的进料以产生产品,其中至少一部分包括剪切固体; 以及从产品中分离出至少一些剪切的固体以产生组分还原产物,其中进料流中的固体组分包含第一颗粒密度,并且其中产物中的剪切固体包含大于 第一颗粒密度。 在一些实施方案中,进料的固体组分包含被捕获在其中的气体,并且其中至少一部分所述气体在剪切时从固体组分释放。 本文还公开了通过在高剪切装置中处理进料流以在包含固体组分的进料流中粉碎固体以产生包含粉碎固体的产物流的方法。

    SYSTEM AND PROCESS FOR THERMAL CRACKING AND STEAM CRACKING
    40.
    发明申请
    SYSTEM AND PROCESS FOR THERMAL CRACKING AND STEAM CRACKING 审中-公开
    热裂解和蒸汽破碎的系统和方法

    公开(公告)号:US20140209508A1

    公开(公告)日:2014-07-31

    申请号:US13790697

    申请日:2013-03-08

    Abstract: Herein disclosed is a method for thermal cracking or steam cracking of hydrocarbons comprising: supersaturating a hydrocarbonaceous liquid or slurry stream in a high shear device with a gas stream comprising steam or hydrogen and optionally one or more C1-C6 hydrocarbons to form a supersaturated dispersion; and introducing the supersaturated dispersion into a thermal cracking or steam cracking reactor to generate a product stream. In some embodiments, the method further comprises contacting the supersaturated dispersion with a cracking catalyst in a slurry, a fluidized catalyst bed, or a fixed catalyst bed. In some embodiments, the cracking catalyst is mixed with the hydrocarbonaceous liquid or slurry stream and the gas stream in the high shear device. Herein also disclosed is a system for thermal cracking or steam cracking of hydrocarbons.

    Abstract translation: 本文公开了一种用于烃的热裂化或蒸汽裂化的方法,其包括:在高剪切装置中用含有蒸汽或氢气的气流和任选的一种或多种C 1 -C 6烃过饱和含烃液体或浆料流以形成过饱和分散体; 并将过饱和分散体引入热裂解或蒸汽裂解反应器中以产生产物流。 在一些实施方案中,该方法还包括使过饱和分散体与浆料,流化催化剂床或固定催化剂床中的裂化催化剂接触。 在一些实施方案中,裂化催化剂与烃类液体或浆料流以及高剪切装置中的气流混合。 本文还公开了一种用于烃的热裂解或蒸汽裂化的系统。

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