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公开(公告)号：US11291221B2
公开(公告)日：2022-04-05
申请号：US15771798
申请日：2016-10-28
发明人： Detlef Schuppan , Victor Zevallos
IPC分类号： A23L5/20 , A23L7/104 , A21D6/00 , A21D13/066
摘要： The present invention features methods of extracting amylase trypsin inhibitors (ATIs) from processed and unprocessed foodstuff, determining bioactivity of ATIs, quantifying the amount of ATIs in a foodstuff, and reducing the content of ATIs in a foodstuff.
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32.发明申请公开(公告)号：US20220096622A1
公开(公告)日：2022-03-31
申请号：US17457705
申请日：2021-12-06
发明人： Dan BAROUCH , Johanna SCHUITEMAKER , Maria Grazia PAU , Danielle VAN MANEN , Frank TOMAKA , Jennifer Anne HENDRIKS
IPC分类号： A61K39/21 , C07K14/005 , C12N15/86 , A61K39/12 , C12N7/00
摘要： Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
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公开(公告)号：US11274301B2
公开(公告)日：2022-03-15
申请号：US15727156
申请日：2017-10-06
IPC分类号： C12N15/11 , C12N15/113 , A61K45/06
摘要： The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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公开(公告)号：US20220064597A1
公开(公告)日：2022-03-03
申请号：US17414907
申请日：2019-12-18
IPC分类号： C12N5/0783 , A61K35/17 , G01N33/50
摘要： A cell culture platform that uses a combination of sophisticated tissue engineering technologies to co-culture patient-derived tumor cells and the patient's own immune cells and create the conditions for expansion of tumor targeting T cells in culture. The platform can be used, e.g., for personalized medicine.
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公开(公告)号：US11230572B2
公开(公告)日：2022-01-25
申请号：US16342866
申请日：2017-10-17
摘要： The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
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公开(公告)号：US20210373037A1
公开(公告)日：2021-12-02
申请号：US17169765
申请日：2021-02-08
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL , BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BETH ISRAEL DEACONESS MEDICAL CENTER
发明人： Utkan Demirci , Ionita Ghiran , Savas Tasoglu , Ronald W. Davis , Lars Steinmetz , Naside Gozde Durmus , Huseyin Cumhur Tekin
IPC分类号： G01N33/80 , G01N15/06 , G01N15/10 , B01L3/00 , B03C1/32 , G01N27/76 , G01N33/487 , C12N13/00 , C12Q1/18 , G01N33/49 , G01N33/574
摘要： Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
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公开(公告)号：US20210283223A1
公开(公告)日：2021-09-16
申请号：US16324945
申请日：2017-08-15
IPC分类号： A61K38/19 , A61K48/00 , A61K35/761 , A61P3/10
摘要： The disclosure relates to the use of A20 to restore glycemic control in a subject in need thereof, for example, a subject having diabetes. This novel approach provides non-insulin based therapy for diabetes.
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公开(公告)号：US11116784B2
公开(公告)日：2021-09-14
申请号：US16079963
申请日：2017-02-21
发明人： Samir M. Parikh
IPC分类号： A61K31/7084 , A61K31/4409 , A61K31/44 , A61P41/00 , A61K31/403 , A61K31/455 , A61K31/706 , A61K31/711 , A61P13/12 , C12N15/113 , A61P9/10 , G01N33/50
摘要： Methods of treating ischemic tissue injury or kidney disease, e.g., delayed graft function, that include administering a Nicotinamide adenine dinucleotide (NAD)/niacinamide (NAM) pathway agonist.
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39.发明申请公开(公告)号：US20210246170A1
公开(公告)日：2021-08-12
申请号：US17163357
申请日：2021-01-30
发明人： Johannes Petrus Maria LANGEDIJK , Lucy RUTTEN , Mark Johannes Gerardus BAKKERS , Rinke BOS , Frank WEGMANN , David Adrianus Theodorus Maria ZUIJDGEEST , Dan H. BAROUCH , An VANDEBOSCH , Mathieu Claude Michel le GARS , Jerald C. SADOFF
IPC分类号： C07K14/005 , A61P31/14 , C12N7/00 , C12N15/86 , A61K39/215
摘要： The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines.
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公开(公告)号：US11084789B2
公开(公告)日：2021-08-10
申请号：US16738371
申请日：2020-01-09
发明人： Lijun Sun , Aristidis Veves
IPC分类号： C07D209/42 , C07D231/56 , C07D417/12 , C07D209/36 , A61P17/02 , C07D401/12
摘要： Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.
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