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公开(公告)号：US11274301B2
公开(公告)日：2022-03-15
申请号：US15727156
申请日：2017-10-06
IPC分类号： C12N15/11 , C12N15/113 , A61K45/06
摘要： The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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2.发明申请公开(公告)号：US20180195067A1
公开(公告)日：2018-07-12
申请号：US15845573
申请日：2017-12-18
发明人： Pier Paolo Pandolfi , Assaf C. Bester , Yvonne Tay
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/113 , A61P35/00 , C12N15/1135 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2750/14143 , C12N2310/3521
摘要： Novel mIR-330 agents and their methods of use are provided. Methods of treating MYC-associated cancers are provided.
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3.发明授权公开(公告)号：US10443055B2
公开(公告)日：2019-10-15
申请号：US15845573
申请日：2017-12-18
发明人： Pier Paolo Pandolfi , Assaf C. Bester , Yvonne Tay
IPC分类号： C07H21/04 , C12N15/113 , A61P35/00
摘要： Novel mIR-330 agents and their methods of use are provided. Methods of treating MYC-associated cancers are provided.
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公开(公告)号：US20180073025A1
公开(公告)日：2018-03-15
申请号：US15727156
申请日：2017-10-06
IPC分类号： C12N15/113 , A61K45/06
CPC分类号： C12N15/113 , A61K45/06 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2320/30
摘要： The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oliognucleotides, including locked nucleic acids (LNAs).
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