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公开(公告)号：US10512631B2
公开(公告)日：2019-12-24
申请号：US15769301
申请日：2016-09-23
发明人： Barbara Wegiel , Lijun Sun
IPC分类号： A61K31/404 , A61P35/02 , C07D209/08 , C07D209/60
摘要： This disclosure relates to the compounds of formula (I): [INSERT FORMULA], in which A and R1-R12 are defined in the Specification. The compounds of formula (I) have therapeutic effects, such as treating cancers.
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公开(公告)号：US20200148638A1
公开(公告)日：2020-05-14
申请号：US16738371
申请日：2020-01-09
发明人： Lijun Sun , Aristidis Veves
IPC分类号： C07D209/42 , C07D231/56 , C07D417/12 , C07D209/36 , A61P17/02 , C07D401/12
摘要： Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.
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公开(公告)号：US20190016680A1
公开(公告)日：2019-01-17
申请号：US16069961
申请日：2017-01-13
发明人： Lijun Sun , Aristidis Veves
IPC分类号： C07D209/42 , A61P17/02 , C07D231/56 , C07D401/12 , C07D417/12
摘要： Provided are novel compounds of Formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.
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公开(公告)号：US10548864B2
公开(公告)日：2020-02-04
申请号：US15557731
申请日：2016-03-10
发明人： Kun Ping Lu , Xiao Zhen Zhou , Shuo Wei , Lijun Sun , Michelle Lynn Hall
IPC分类号： A61K31/196 , A61K45/06 , A61K31/122 , A61K31/4152 , A61K31/4166 , A61K31/4192 , A61K31/4245 , A61K31/452 , A61K31/5375 , A61K31/203 , A61K31/4196
摘要： The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.
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公开(公告)号：US11634408B2
公开(公告)日：2023-04-25
申请号：US17045116
申请日：2019-04-05
发明人： Elliot Chaikof , Lijun Sun
IPC分类号： C07D403/06 , C07D401/06 , C07D409/06 , C07D471/04 , C07D209/12 , A61P29/00
摘要： Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.
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公开(公告)号：US11084789B2
公开(公告)日：2021-08-10
申请号：US16738371
申请日：2020-01-09
发明人： Lijun Sun , Aristidis Veves
IPC分类号： C07D209/42 , C07D231/56 , C07D417/12 , C07D209/36 , A61P17/02 , C07D401/12
摘要： Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.
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公开(公告)号：US20180303797A1
公开(公告)日：2018-10-25
申请号：US15769301
申请日：2016-09-23
发明人： Barbara Wegiel , Lijun Sun
IPC分类号： A61K31/404 , A61P35/02
摘要： This disclosure relates to the compounds of formula (I) [INSERT FORMULA], in which A and R1-R12 are defined in the Specification. The compounds of formula (I) have therapeutic effects, such as treating cancers.
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公开(公告)号：US20230278986A1
公开(公告)日：2023-09-07
申请号：US18181099
申请日：2023-03-09
发明人： Elliot Chaikof , Lijun Sun
IPC分类号： C07D403/06 , C07D401/06 , C07D409/06 , C07D471/04
CPC分类号： C07D403/06 , C07D401/06 , C07D409/06 , C07D471/04
摘要： Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1—X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.
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公开(公告)号：US11697640B2
公开(公告)日：2023-07-11
申请号：US17307922
申请日：2021-05-04
发明人： Bruce R. Zetter , Lijun Sun
IPC分类号： A61K31/4184 , A61K31/4439 , C07D235/32 , A61P35/00 , C07D401/14 , C07D403/12 , C07D405/12 , C07D401/12
CPC分类号： C07D235/32 , A61K31/4184 , A61K31/4439 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12
摘要： The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
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公开(公告)号：US20220153735A1
公开(公告)日：2022-05-19
申请号：US17435863
申请日：2020-03-03
发明人： Lijun Sun
IPC分类号： C07D471/04 , C07D401/12 , C07D209/24 , C07D231/14 , C07D231/54 , C07D487/04
摘要： The present application provides a compound of Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions containing these compounds, and methods of using these compounds for treating cancer, autoimmune diseases, and inflammatory diseases are also provided.
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