公开(公告)号：US11746090B2

公开(公告)日：2023-09-05

申请号：US17986419

申请日：2022-11-14

申请人： IMBRIA PHARMACEUTICALS, INC.

发明人： Neil Buckley ,  Dan Belmont ,  Sarah Bethune ,  Krista Diaz

IPC分类号： C07D213/80

CPC分类号： C07D213/80 ,  C07B2200/13

摘要： The invention provides polymorphs of a compound of Formula (X):




The invention also provided pharmaceutical compositions containing polymorphs of the compound and methods treating conditions in a subject by providing polymorphs of the compound.

公开(公告)号：US11724095B2

公开(公告)日：2023-08-15

申请号：US16801952

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M1/10 ,  A61M60/414 ,  A61M25/10 ,  A61M1/00 ,  A61M60/126

CPC分类号： A61M60/414 ,  A61M25/10 ,  A61M25/1002 ,  A61M1/85 ,  A61M60/126 ,  A61M2205/0216 ,  A61M2205/3331 ,  A61M2205/7536

摘要： The disclosure relates to devices and methods for the treatment of edema using a purge-free system. The invention provides devices and methods useful for treating edema by means of an indwelling catheter that is placed in a blood vessel of a patient and used to pump blood to cause a decrease in pressure at an outlet of a lymphatic duct. The catheter pumps blood by means of an impeller but is purge-free in that the catheter does not include a system for purging or flushing catheter components with a purge fluid. The purge-free catheter avoids blood-related mechanical complications such as clotting or thrombosis by means of an impermeable sleeve or shroud that protects moving parts of the impeller drive system.

公开(公告)号：US11715633B2

公开(公告)日：2023-08-01

申请号：US17464135

申请日：2021-09-01

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Zhenwei Wei ,  David G. McLaren

IPC分类号： H01J49/16 ,  H01J49/04

CPC分类号： H01J49/167 ,  H01J49/0409 ,  H01J49/0431

摘要： The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.

公开(公告)号：US11701392B2

公开(公告)日：2023-07-18

申请号：US17104011

申请日：2020-11-25

申请人： MEDEOR THERAPEUTICS, INC.

发明人： Steven R. Deitcher

IPC分类号： A61K35/28

CPC分类号： A61K35/28

摘要： The invention provides compositions for establishing mixed chimerism in a subject. The compositions include CD34+ cells that have been column-purified from an apheresis product and CD3+ cells from an apheresis product that have not been purified through a column. The invention also provides methods of making and using such compositions.

公开(公告)号：US11696747B2

公开(公告)日：2023-07-11

申请号：US16650032

申请日：2017-09-29

申请人： Nanovare SAS

发明人： Daniel Thomas ,  Mohamed Hamza ,  Fanny Chesa

IPC分类号： A61B10/00 ,  B01L3/00 ,  G01N15/14 ,  G01N33/487

CPC分类号： A61B10/0058 ,  B01L3/50273 ,  B01L3/502715 ,  G01N15/1434 ,  G01N33/487 ,  B01L2300/023 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/168 ,  B01L2400/0475 ,  G01N2800/367

摘要： Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.

公开(公告)号：US11686665B2

公开(公告)日：2023-06-27

申请号：US17826786

申请日：2022-05-27

申请人： NODEXUS INC.

发明人： Hany Nassef ,  Karthik Balakrishnan ,  Anand Kesavaraju ,  Vincent Tuminelli ,  George Anwar

IPC分类号： G01N15/14 ,  B01L3/00 ,  B07C5/342 ,  B07C5/344 ,  G01N15/10

CPC分类号： G01N15/1484 ,  B01L3/502715 ,  B01L3/502761 ,  B07C5/344 ,  B07C5/3425 ,  G01N15/1459 ,  B01L2200/0652 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/06 ,  G01N2015/1006 ,  G01N2015/1081

摘要： Disclosed herein is a system to detect and characterize individual particles and cells using at least either optic or electric detection as the particle or cell flows through a microfluidic channel. The system also provides for sorting particles and cells or isolating individual particles and cells.

公开(公告)号：US11680876B2

公开(公告)日：2023-06-20

申请号：US17346576

申请日：2021-06-14

申请人： Purdue Research Foundation

发明人： Zheng Ouyang ,  Wenpeng Zhang

IPC分类号： G01N1/40 ,  B01D11/00 ,  B01D11/02 ,  B01D15/10 ,  H01J49/00 ,  H01J49/04

CPC分类号： G01N1/405 ,  B01D11/00 ,  B01D11/02 ,  B01D15/10 ,  H01J49/0031 ,  H01J49/0436 ,  G01N2001/4061 ,  Y10T436/255

摘要： Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.

公开(公告)号：US11674884B2

公开(公告)日：2023-06-13

申请号：US17826797

申请日：2022-05-27

申请人： NODEXUS INC.

发明人： Hany Nassef ,  Karthik Balakrishnan ,  Anand Kesavaraju ,  Vincent Tuminelli ,  George Anwar

IPC分类号： G01N15/14 ,  B01L3/00 ,  B07C5/342 ,  B07C5/344 ,  G01N15/10

CPC分类号： G01N15/1484 ,  B01L3/502715 ,  B01L3/502761 ,  B07C5/344 ,  B07C5/3425 ,  G01N15/1459 ,  B01L2200/0652 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/06 ,  G01N2015/1006 ,  G01N2015/1081

摘要： Disclosed herein is a system to detect and characterize individual particles and cells using at least either optic or electric detection as the particle or cell flows through a microfluidic channel. The system also provides for sorting particles and cells or isolating individual particles and cells.

公开(公告)号：US11666378B2

公开(公告)日：2023-06-06

申请号：US16701843

申请日：2019-12-03

申请人： Neurent Medical Limited

发明人： David Townley ,  Brian Shields

IPC分类号： A61B18/14 ,  A61B34/10 ,  A61B34/20 ,  A61N1/05 ,  G06T7/00 ,  A61N1/40 ,  A61B90/00 ,  A61B90/92 ,  A61B90/94 ,  A61B18/02 ,  A61B18/12 ,  A61B18/20 ,  A61B17/00 ,  A61B18/00 ,  A61B18/18

CPC分类号： A61B18/1485 ,  A61B18/14 ,  A61B34/10 ,  A61B34/20 ,  A61N1/0546 ,  A61N1/403 ,  G06T7/0012 ,  A61B18/02 ,  A61B18/1206 ,  A61B18/20 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/00199 ,  A61B2017/00292 ,  A61B2017/00424 ,  A61B2017/00867 ,  A61B2018/0016 ,  A61B2018/00166 ,  A61B2018/00214 ,  A61B2018/00303 ,  A61B2018/00327 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/00922 ,  A61B2018/00946 ,  A61B2018/126 ,  A61B2018/1253 ,  A61B2018/144 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1823 ,  A61B2034/102 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3735 ,  A61B2090/3762 ,  A61B2218/007

摘要： The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

公开(公告)号：US11660426B2

公开(公告)日：2023-05-30

申请号：US16801994

申请日：2020-02-26

申请人： White Swell Medical Ltd

发明人： Yaacov Nitzan ,  Ronan Keating ,  Shahaf Marmur ,  Or Inbar ,  Eamon Brady ,  Gerry McCaffrey ,  Reed Williston ,  Sagi Raz

IPC分类号： A61M25/10

CPC分类号： A61M25/1018 ,  A61M25/10 ,  A61M2025/1022 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2210/125

摘要： The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.