公开(公告)号：US20220213196A1

公开(公告)日：2022-07-07

申请号：US17269246

申请日：2019-08-16

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Godfrey Jonah Anderson Rainey ,  Wade Blair ,  Michele Anne Busby ,  Jennifer Busby ,  Gijsbert Marnix Grotenbreg ,  Mojca Skoberne ,  Roman Yelensky

IPC: C07K16/28 ,  C07K14/47 ,  C07K14/74 ,  C07K16/30 ,  C12N15/10 ,  C40B40/08 ,  C40B40/10

Abstract: Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets as well as identifying one or more antigen binding proteins that bind a given HLA-PEPTIDE target.

公开(公告)号：US11377655B2

公开(公告)日：2022-07-05

申请号：US16931200

申请日：2020-07-16

Applicant: Omniome, Inc.

Inventor： Arnold Oliphant ,  James Yu

IPC: C12N15/10 ,  C40B40/08 ,  C12N15/11

Abstract: Nucleic acid compositions having nucleotide sequences that do not occur in nature are provided. Also provided are populations of different nucleic acids having universal adapters or universal primer binding sites. Methods of capturing, copying or amplifying nucleic acids of interest using universal adapters, universal primer binding sites and/or universal primers are also provided.

公开(公告)号：US11359186B2

公开(公告)日：2022-06-14

申请号：US16001031

申请日：2018-06-06

Applicant: Hiroshima University

Inventor： Takashi Yamamoto ,  Tetsushi Sakuma ,  Hiroshi Ochiai ,  Shinya Matsuura ,  Tatsuo Miyamoto

IPC: C12N15/00 ,  C12N9/22 ,  C12N15/63 ,  C40B40/08

Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.

公开(公告)号：US11352714B1

公开(公告)日：2022-06-07

申请号：US16293067

申请日：2019-03-05

Applicant: Verily Life Sciences LLC

Inventor： Jerrod Schwartz ,  Ci Chu ,  Charles Kim ,  Bi Yu Li ,  Xiaomi Du

IPC: C40B40/08 ,  C12Q1/686 ,  G01N33/68 ,  C40B20/02 ,  C12Q1/6806

Abstract: Provided herein are methods for identification of an expression profile, a transcriptional profile, and/or an epigenetic profile from a cell-containing sample. Also provided are compositions for use in the disclosed methods.

公开(公告)号：US11319594B2

公开(公告)日：2022-05-03

申请号：US15685834

申请日：2017-08-24

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher Raymond ,  Lee Lim ,  Jennifer Hernandez

IPC: C12Q1/6886 ,  G16B20/00 ,  G16B30/00 ,  C12Q1/68 ,  C12Q1/6809 ,  G16B30/10 ,  G16B20/40 ,  G16B20/10 ,  G16B25/10 ,  G16B20/20 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q1/6851 ,  C40B40/08

Abstract: The present invention includes compositions and methods useful for the detection of a mutational change, SNP, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic DNA or cell-free DNA (cfDNA). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfDNA from a biological sample (e.g., blood).

公开(公告)号：US11254931B2

公开(公告)日：2022-02-22

申请号：US17208877

申请日：2021-03-22

Applicant: SPECIFICA INC.

Inventor： Andrew Raymon Morton Bradbury ,  Michael Frank Erasmus ,  Andre Teixeira

IPC: C40B50/06 ,  C12N15/10 ,  C12N15/81 ,  C40B40/10 ,  C40B40/08

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

公开(公告)号：US20210347855A1

公开(公告)日：2021-11-11

申请号：US17190626

申请日：2021-03-03

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Institut Curie ,  Universite Paul Sabatier Toulouse III ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： Aurelien Olichon ,  Sandrine Moutel ,  Franck Perez

IPC: C07K16/00 ,  C07K16/32 ,  C07K16/44 ,  C40B40/08 ,  C07K16/40

Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.

公开(公告)号：US20210317526A1

公开(公告)日：2021-10-14

申请号：US17356293

申请日：2021-06-23

Applicant: Fred Hutchinson Cancer Research Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C40B40/08 ,  C40B50/06 ,  C12Q1/6827 ,  C12N15/10 ,  C12N15/81 ,  C12N15/85 ,  C12N15/70 ,  C12Q1/6869

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US11078498B2

公开(公告)日：2021-08-03

申请号：US16938739

申请日：2020-07-24

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Andrew Garst ,  Ryan T Gill

IPC: C12N15/90 ,  C12N15/10 ,  C40B40/08 ,  C12N15/11 ,  C12N9/22

Abstract: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.

公开(公告)号：US11008568B2

公开(公告)日：2021-05-18

申请号：US16236259

申请日：2018-12-28

Applicant: Adimab, LLC

Inventor： Maximiliano Vasquez ,  Michael Feldhaus ,  Tillman U. Gerngross ,  K. Dane Wittrup

IPC: C40B50/06 ,  C12N15/10 ,  C07K16/00 ,  C40B40/08

Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.