公开(公告)号：US10907149B2

公开(公告)日：2021-02-02

申请号：US15873510

申请日：2018-01-17

Applicant: RESOLUTION BIOSCIENCE, INC.

Inventor： Christopher K. Raymond ,  Christopher D. Armour ,  Lee P. Lim

IPC: C12Q1/68 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6888

Abstract: The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provide methods for the sensitive and specific detection of target gene sequences and gene expression profiles.

公开(公告)号：US20240191293A1

公开(公告)日：2024-06-13

申请号：US18553503

申请日：2022-03-30

Applicant: Resolution Bioscience, Inc.

Inventor： Jiannan Guo ,  Carolyn Hutcheon ,  Mark Li ,  Lee Lim ,  Ira Pekker ,  Chen-Hsun Tsai

IPC: C12Q1/6874 ,  C12Q1/6876

CPC classification number: C12Q1/6874 ,  C12Q1/6876 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/166

Abstract: The disclosure provides compositions and methods that combine the benefits of different genetic analysis methods by performing simultaneous genetic analysis on a single pool of different libraries that were generated for different approaches, such as a combined library comprising a LPWG library and a target-enriched library.

公开(公告)号：US11339391B2

公开(公告)日：2022-05-24

申请号：US15965048

申请日：2018-04-27

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher K. Raymond ,  Lee P. Lim

IPC: C12N15/10 ,  C12Q1/686 ,  C12Q1/6869 ,  C12N15/66 ,  C12Q1/6827 ,  C12Q1/6855 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention provides a method for efficient DNA library construction and targeted genetic analyses of the libraries.

公开(公告)号：US20220073906A1

公开(公告)日：2022-03-10

申请号：US17469343

申请日：2021-09-08

Applicant: RESOLUTION BIOSCIENCE, INC.

Inventor： Jiannan GUO ,  Jennifer HERNANDEZ

IPC: C12N15/10

Abstract: The disclosure provides compositions and methods for the multiplexed detecting and analyzing of cellular nucleic acids. In some embodiments, the disclosure provides multifunctional adaptors for use in methods of the disclosure. In some embodiments, compositions and methods of the disclosure are automatable.

公开(公告)号：US20180245072A1

公开(公告)日：2018-08-30

申请号：US15965048

申请日：2018-04-27

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher K. RAYMOND ,  Lee P. LIM

IPC: C12N15/10 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6855

CPC classification number: C12N15/1093 ,  C12N15/66 ,  C12Q1/6827 ,  C12Q1/6855 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2521/501 ,  C12Q2521/525 ,  C12Q2521/531 ,  C12Q2525/186 ,  C12Q2525/191 ,  C12Q2535/122

Abstract: The invention provides a method for efficient DNA library construction and targeted genetic analyses of the libraries.

公开(公告)号：US20180179578A1

公开(公告)日：2018-06-28

申请号：US15727887

申请日：2017-10-09

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher K. RAYMOND ,  Lee P. LIM ,  Christopher D. ARMOUR

IPC: C12Q1/6806 ,  G06F19/18 ,  G06F19/22 ,  C12Q1/6869

CPC classification number: C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  C12Q2525/191 ,  C12Q2545/114 ,  C12Q2563/159

Abstract: The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provides methods for the sensitive and specific detection of target gene sequences and gene expression profiles.

公开(公告)号：US20220259659A1

公开(公告)日：2022-08-18

申请号：US17627535

申请日：2020-06-18

Applicant: RESOLUTION BIOSCIENCE, INC.

Inventor： Chris RAYMOND ,  Jennifer HERNANDEZ ,  Tristan SHAFFER

IPC: C12Q1/6883 ,  C12N15/10

Abstract: The present disclosure relates generally to methods for targeted hybrid capture of rearranged T cell receptors. More particularly, some embodiments relate to a method for direct and quantitative, error-corrected counting of genomic sequences for determining immune response gene repertoires.

公开(公告)号：US20180163272A1

公开(公告)日：2018-06-14

申请号：US15685834

申请日：2017-08-24

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher Raymond ,  Lee Lim ,  Jennifer Hernandez

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6869 ,  G06F19/18 ,  G06F19/22 ,  C12Q1/686

CPC classification number: C12Q1/6886 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q2525/191 ,  C12Q2545/114 ,  C12Q2563/159 ,  C12Q2563/179 ,  C12Q2600/156 ,  C40B40/08 ,  G01N2570/00 ,  G01N2800/7028 ,  G16B20/00 ,  G16B30/00 ,  C12Q2565/514

Abstract: The present invention includes compositions and methods useful for the detection of a mutational change, SNP, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic DNA or cell-free DNA (cfDNA). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfDNA from a biological sample (e.g., blood).

公开(公告)号：US12203127B2

公开(公告)日：2025-01-21

申请号：US15727887

申请日：2017-10-09

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher K. Raymond ,  Lee P. Lim ,  Christopher D. Armour

IPC: C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B25/00 ,  G16B25/10 ,  G16B30/00 ,  G16B30/10

Abstract: The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provides methods for the sensitive and specific detection of target gene sequences and gene expression profiles.

公开(公告)号：US11999949B2

公开(公告)日：2024-06-04

申请号：US17141510

申请日：2021-01-05

Applicant: Resolution Bioscience, Inc.

Inventor： Christopher K. Raymond ,  Christopher D. Armour ,  Lee P. Lim

IPC: C12Q1/68 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6888

CPC classification number: C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6888 ,  C12Q1/6827 ,  C12Q2521/325 ,  C12Q2525/179 ,  C12Q2531/113 ,  C12Q2537/16 ,  C12Q1/6806 ,  C12Q2525/155 ,  C12Q2525/179 ,  C12Q2525/191 ,  C12Q2531/113

Abstract: The invention provides a method for genetic analysis in individuals that reveals both the genetic sequences and chromosomal copy number of targeted and specific genomic loci in a single assay. The present invention further provide methods for the sensitive and specific detection of target gene sequences and gene expression profiles.