公开(公告)号：US20040133936A1

公开(公告)日：2004-07-08

申请号：US10362024

申请日：2003-09-25

发明人： John Rossiter ,  Atle Bones ,  Alex Jones ,  Per Winge

IPC分类号： A01H001/00 ,  A01H005/00 ,  C12N015/82 ,  C07H021/04 ,  C12N009/24 ,  C12N005/04

CPC分类号： C12Y302/01147 ,  A61K38/47 ,  C12N9/2402 ,  C12N15/8242 ,  C12N15/8243 ,  C12Q1/34

摘要： Amino acid sequences and nucleotide sequences relating to aphid myrosinase are described. In a preferred aspect, the amino acid sequence comprises the sequence presented as SEQ ID No. 1.

摘要翻译： 描述了与蚜虫黑芥子酶有关的氨基酸序列和核苷酸序列。 在优选的方面，氨基酸序列包含SEQ ID No.1所示的序列。

公开(公告)号：US20180207186A1

公开(公告)日：2018-07-26

申请号：US15747993

申请日：2016-07-15

申请人： FUNDACIÓN TECNALIA RESEARCH & INNOVATION

发明人： Jessica SÁENZ GÓMEZ ,  Laura OLIVER GARCÍA ,  María Carmen VILLARÁN VELASCO

IPC分类号： A61K31/7028 ,  A23L33/105 ,  A23L33/125 ,  A23P10/30 ,  A61K9/50 ,  A61K38/47 ,  A61K36/31

CPC分类号： A61K31/7028 ,  A23L29/06 ,  A23L33/105 ,  A23L33/125 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/5052 ,  A61K9/5089 ,  A61K36/31 ,  A61K38/47 ,  C12N9/2402 ,  C12Y302/01147

摘要： Disclosed is a formulation which contains microcapsules which contain a core containing an extract rich in glucosinolates obtained from crucifers and a biopolymer, and an enteric coating containing myrosinase and a biopolymer. Also, disclosed is a procedure for obtaining the same and to a use of the formulation as such, or in dietetic food supplements for humans or animals due to its immunostimulant activity.

公开(公告)号：US20180200344A9

公开(公告)日：2018-07-19

申请号：US15244374

申请日：2016-08-23

申请人： NUTRAMAX LABORATORIES, INC.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A61K38/47 ,  A61K31/7028 ,  A61K31/375 ,  A61K31/716 ,  A61K36/31 ,  A61K36/07 ,  A61K31/26

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.

公开(公告)号：US20150190443A1

公开(公告)日：2015-07-09

申请号：US14660748

申请日：2015-03-17

申请人： Jarrow Formulas, Inc.

发明人： Kean Ashurst

IPC分类号： A61K36/31 ,  A61K9/00 ,  A61K31/7028 ,  A61K38/47 ,  A61K31/375

CPC分类号： A61K36/31 ,  A23L33/105 ,  A61K9/0053 ,  A61K31/375 ,  A61K31/7028 ,  A61K38/47 ,  C12Y302/01147

摘要： A nutritional supplement is provided containing two broccoli based components that are combined and, when ingested, react in the intestines to provide sulforaphane. Processes for producing the broccoli components of the nutritional supplement are also provided. The broccoli components are treated separately using supercritical fluid extraction to remove oils. The temperature and pressure of the supercritical extraction processes are controlled to provide broccoli components having the desired properties for the nutritional supplement.

摘要翻译： 提供了一种营养补充剂，其含有两种以西兰花为基础的组分，其组合并且在摄入时在肠中反应以提供萝卜硫素。 还提供了用于生产营养补充剂的花椰菜成分的方法。 使用超临界流体萃取分离处理西兰花组分以除去油。 控制超临界萃取过程的温度和压力以提供具有营养补充剂所需性质的花椰菜成分。

公开(公告)号：US20150174093A1

公开(公告)日：2015-06-25

申请号：US14412189

申请日：2013-07-03

申请人： Nutramax Laboratories, Inc.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson ,  Ronald Kettenacker

IPC分类号： A61K31/26 ,  A61K33/06 ,  A61K45/06 ,  A61K38/47 ,  A61K31/375 ,  A61K36/31 ,  A61K31/7028

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and magnesium or a salt or complex thereof. The invention also relates to the combination of a sulforaphane or a derivative thereof and magnesium or a salt or complex thereof. The invention also relates to the combination of a broccoli extract or powder and magnesium or a salt or complex thereof. The invention provides compositions and methods relating to these combinations.

摘要翻译： 本发明涉及萝卜硫素前体，能够将萝卜硫素前体转化为萝卜硫素的酶，酶增效剂以及镁或其盐或复合物的组合。 本发明还涉及萝卜硫素或其衍生物与镁或其盐或络合物的组合。 本发明还涉及西兰花提取物或粉末与镁或其盐或其复合物的组合。 本发明提供了与这些组合有关的组合物和方法。

公开(公告)号：US20150110872A1

公开(公告)日：2015-04-23

申请号：US14586765

申请日：2014-12-30

申请人： Nutramax Laboratories, Inc.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A61K38/47 ,  A61K31/375 ,  A61K31/26 ,  A61K45/06 ,  A61K36/31 ,  A61K31/7028 ,  A61K36/07

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  C12Y302/01147 ,  A61K2300/00

摘要： The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The invention also relates to the combination of sulforaphane or a derivative thereof and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present invention also relates to the combination of a broccoli extract or powder and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present provides compositions and methods relating to these combinations.

公开(公告)号：US08927007B2

公开(公告)日：2015-01-06

申请号：US13577181

申请日：2011-09-14

申请人： Paul Talalay ,  Jed Fahey ,  Antony Talalay

发明人： Paul Talalay ,  Jed Fahey ,  Antony Talalay

IPC分类号： A61K38/47 ,  A61K31/7028 ,  A61K31/26 ,  A23L1/305 ,  A23L1/03 ,  A61K9/00 ,  A61K9/06 ,  A61K9/127

CPC分类号： A61K38/47 ,  A23L29/06 ,  A23L33/17 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/127 ,  A61K31/26 ,  A61K31/7028 ,  C12Y302/01147

摘要： The application relates to topical formulations comprising a phase II enzyme inducer precursor and an activating agent. Methods for producing and using the topical formulations are also provided.

摘要翻译： 本申请涉及包含II期酶诱导剂前体和活化剂的局部制剂。 还提供了制备和使用局部制剂的方法。

公开(公告)号：US20130323225A1

公开(公告)日：2013-12-05

申请号：US13910576

申请日：2013-06-05

申请人： Jarrow Formulas, Inc.

发明人： Kean Ashurst

IPC分类号： A23L1/30

CPC分类号： A61K36/31 ,  A23L33/105 ,  A61K9/0053 ,  A61K31/375 ,  A61K31/7028 ,  A61K38/47 ,  C12Y302/01147

摘要： A nutritional supplement is provided containing two broccoli based components that are combined and, when ingested, react in the intestines to provide sulforaphane. Processes for producing the broccoli components of the nutritional supplement are also provided. The broccoli components are treated separately using supercritical fluid extraction to remove oils. The temperature and pressure of the supercritical extraction processes are controlled to provide broccoli components having the desired properties for the nutritional supplement.

公开(公告)号：US20110245526A1

公开(公告)日：2011-10-06

申请号：US12750999

申请日：2010-03-31

申请人： Athula Ekanayake ,  Scott Alan Vandiest ,  Jeffrey John Kester ,  Paul Henry Zoutendam ,  Jairus R.D. David

发明人： Athula Ekanayake ,  Scott Alan Vandiest ,  Jeffrey John Kester ,  Paul Henry Zoutendam ,  Jairus R.D. David

IPC分类号： C07C331/16 ,  C07C331/28

CPC分类号： A61K36/31 ,  C12P11/00 ,  C12P13/00 ,  C12Y302/01147

摘要： A process for producing an essential oil. The essential oil can be white mustard essential oil. The white mustard essential oil can include a moisture sensitive isothiocyanate compound. The moisture sensitive isothiocyanate compound can be 4-HBITC. The essential oil can be produced from mustard seed, which can comprise a precursor sinalbin and myrosinase enzyme. The mustard seed can be reduced into a powder. Activation of the myrosinase enzyme by using a water solvent and a promoter to form a slurry can be performed, wherein the myrosinase enzyme catalyzes the production of an essential oil comprising an isothiocyanate from the sinalbin precursor.

摘要翻译： 一种生产精油的方法。 精油可以是芥末精油。 白芥精油可以包括湿敏性异硫氰酸酯化合物。 水分敏感的异硫氰酸酯化合物可以是4-HBITC。 精油可以由芥子籽生产，其可以包含前体锡胺素和黑芥子酶。 芥菜籽可以还原成粉末。 可以进行使用水溶剂和促进剂来形成浆液来激活黑芥子酶，其中所述黑芥子酶催化从所述西宁酯前体产生包含异硫氰酸酯的精油。

公开(公告)号：US5882646A

公开(公告)日：1999-03-16

申请号：US865327

申请日：1997-05-29

申请人： Donald J. Pusateri ,  William C. Chiang ,  Richard E.A. Letiz ,  Phelicia M. Sperrazzo

发明人： Donald J. Pusateri ,  William C. Chiang ,  Richard E.A. Letiz ,  Phelicia M. Sperrazzo

IPC分类号： A23B7/02 ,  A23B7/06 ,  A23B7/155 ,  A23L1/015 ,  A23L1/064 ,  A23L1/212 ,  A23L1/214 ,  A23L1/30 ,  A61K36/31 ,  A61K35/78

CPC分类号： C12Y302/01147 ,  A23B7/06 ,  A23B7/155 ,  A23L19/01 ,  A23L19/10 ,  A23L5/25

摘要： A brassica vegetable tablet contains at least 50 .mu.g of sulforaphane and a maximum of 50 .mu.g of sulforaphane-nitrile. A process for producing a brassica vegetable product includes inactivating endogenous myrosinase enzyme in a brassica vegetable and thereafter blending the vegetable with exogenous myrosinase enzyme. The preferred process may include steam blanching as the method of inactivating the endogenous myrosinase enzyme. The preferred process may also include horseradish root as the source of exogenous myrosinase enzyme.

摘要翻译： 芸苔属植物片剂含有至少50μg的萝卜硫素和最多50μg的萝卜硫素 - 腈。 制备芸苔属植物产品的方法包括在芸苔属植物中灭活内源性黑芥子酶，然后将植物与外源性黑芥子酶混合。 优选的方法可以包括作为灭活内源性黑芥子酶的方法的蒸汽漂白。 优选的方法还可以包括辣根作为外源黑芥子酶的来源。