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公开(公告)号：US08927007B2
公开(公告)日：2015-01-06
申请号：US13577181
申请日：2011-09-14
申请人： Paul Talalay , Jed Fahey , Antony Talalay
发明人： Paul Talalay , Jed Fahey , Antony Talalay
IPC分类号： A61K38/47 , A61K31/7028 , A61K31/26 , A23L1/305 , A23L1/03 , A61K9/00 , A61K9/06 , A61K9/127
CPC分类号： A61K38/47 , A23L29/06 , A23L33/17 , A61K9/0014 , A61K9/06 , A61K9/127 , A61K31/26 , A61K31/7028 , C12Y302/01147
摘要： The application relates to topical formulations comprising a phase II enzyme inducer precursor and an activating agent. Methods for producing and using the topical formulations are also provided.
摘要翻译： 本申请涉及包含II期酶诱导剂前体和活化剂的局部制剂。 还提供了制备和使用局部制剂的方法。
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公开(公告)号：US20130164365A1
公开(公告)日：2013-06-27
申请号：US13577181
申请日：2011-09-14
申请人： Paul Talalay , Jed Fahey , Antony Talalay
发明人： Paul Talalay , Jed Fahey , Antony Talalay
IPC分类号： A61K38/47 , A61K31/7028
CPC分类号： A61K38/47 , A23L29/06 , A23L33/17 , A61K9/0014 , A61K9/06 , A61K9/127 , A61K31/26 , A61K31/7028 , C12Y302/01147
摘要： The application relates to topical formulations comprising a phase II enzyme inducer precursor and an activating agent. Methods for producing and using the topical formulations are also provided.
摘要翻译： 本申请涉及包含II期酶诱导剂前体和活化剂的局部制剂。 还提供了制备和使用局部制剂的方法。
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公开(公告)号：US20090247477A1
公开(公告)日：2009-10-01
申请号：US11919430
申请日：2006-04-27
IPC分类号： A61K31/7004 , A61K31/13 , A61P35/00
CPC分类号： A61K31/095
摘要： Administration of the isothiocyanate protects against UV light-induced skin carcinogenesis. In particular, topical application or dietary administration of isothiocyanate sulforaphane after exposure to UV radiation provides effective protection against skin tumor formation. Sulforaphane analogs and glucosinolates also can be employed. Lotions useful for suppressing UV light-induced skin carcinogenesis also are provided.
摘要翻译： 异硫氰酸盐的施用可防止紫外光诱导的皮肤癌发生。 特别地，在暴露于紫外线辐射后局部施用或异烟肼异硫氰酸酯萝卜硫素的饮食给予有效的防止皮肤肿瘤形成的保护。 也可以使用萝卜硫烷类似物和硫代葡萄糖苷。 还提供了用于抑制UV光诱导的皮肤致癌作用的乳液。
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4.发明授权Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes 有权预防和治疗谷胱甘肽和II期解毒酶的氧化应激障碍公开(公告)号：US07407986B2
公开(公告)日：2008-08-05
申请号：US10499196
申请日：2002-12-18
IPC分类号： A01N47/40
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译： 本发明一般涉及通过施用药物有效量的提高动物组织中细胞内谷胱甘肽含量或细胞内水平的至少一种II期解毒酶的化合物来治疗氧化应激障碍的领域。 本发明还涉及通过施用药物有效量的提高受试者中的谷胱甘肽的细胞内水平或细胞内水平的至少一种II期解毒酶的化合物来保护受试者免受氧化应激障碍的领域。 本发明还涉及可用于治疗氧化应激障碍的药物组合物。
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公开(公告)号：US07303770B2
公开(公告)日：2007-12-04
申请号：US09825989
申请日：2001-04-05
申请人： Jed W. Fahey , Paul Talalay
发明人： Jed W. Fahey , Paul Talalay
CPC分类号： A61K36/31 , A23L11/20 , A23L19/03 , A23L19/09 , A23L33/105 , A61K36/00 , Y10S210/904 , A61K2300/00
摘要： Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors of isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mammals.
摘要翻译： 已经鉴定出具有非常丰富的硫代葡萄糖苷的代谢前体的硫代葡萄糖苷的癌症化学保护剂的植物来源。 植物来源用于提供降低哺乳动物致癌物水平的饮食方式。
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公开(公告)号：US20110014137A1
公开(公告)日：2011-01-20
申请号：US12761551
申请日：2010-04-16
IPC分类号： A61K31/26 , A61K31/7028 , A61Q17/04 , A61P17/16 , A61P7/10 , A61P29/00 , A61P1/04 , A61P17/00 , A61P35/00
CPC分类号： A61K31/26
摘要： The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical use of Nrf2 inducers.
摘要翻译： 本发明涉及用于保护皮肤和粘膜免受经历电离辐射治疗的患者中电离辐射的不良副作用的方法和组合物。 特别地，本申请描述了包含Nrf2诱导剂的局部使用的组合物和方法。
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7.发明授权Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes 有权预防和治疗谷胱甘肽和II期解毒酶的氧化应激障碍公开(公告)号：US08303949B2
公开(公告)日：2012-11-06
申请号：US12179986
申请日：2008-07-25
IPC分类号： A61K38/44
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译： 本发明一般涉及通过施用药物有效量的在动物组织中升高谷胱甘肽的细胞内水平或至少一种II期解毒酶的细胞内水平的化合物来治疗氧化应激障碍的领域。 本发明还涉及通过施用药物有效量的提高受试者中至少一种II型解毒酶的谷胱甘肽的细胞内水平或细胞内水平的化合物来保护受试者免受氧化应激障碍的领域。 本发明还涉及可用于治疗氧化应激障碍的药物组合物。
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8.发明申请公开(公告)号：US20090017002A1
公开(公告)日：2009-01-15
申请号：US12179986
申请日：2008-07-25
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译： 本发明一般涉及通过施用药物有效量的在动物组织中升高谷胱甘肽的细胞内水平或至少一种II期解毒酶的细胞内水平的化合物来治疗氧化应激障碍的领域。 本发明还涉及通过施用药物有效量的提高受试者中至少一种II型解毒酶的谷胱甘肽的细胞内水平或细胞内水平的化合物来保护受试者免受氧化应激障碍的领域。 本发明还涉及可用于治疗氧化应激障碍的药物组合物。
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公开(公告)号：US5411986A
公开(公告)日：1995-05-02
申请号：US030610
申请日：1993-03-12
申请人： Cheon-Gyu Cho , Gary H. Posner , Paul Talalay , Yuesheng Zhang
发明人： Cheon-Gyu Cho , Gary H. Posner , Paul Talalay , Yuesheng Zhang
IPC分类号： A61K31/145 , A61K31/26 , A61K31/66 , C07C331/20 , C07C331/24 , C07C331/26 , C07C331/28 , C07F9/40 , C07C331/04
CPC分类号： C07C331/28 , A61K31/145 , A61K31/26 , A61K31/66 , C07C331/20 , C07C331/24 , C07C331/26 , C07F9/4006
摘要： Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.
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10.发明授权Novel bacterium inducible to produce unique steroid-transforming enzymes: preparation and applications thereof 失效诱导产生独特类固醇转化酶的新型细菌：其制备及应用
公开(公告)号：US4874696A
公开(公告)日：1989-10-17
申请号：US790447
申请日：1985-10-23
申请人： Donna W. Payne , Paul Talalay
发明人： Donna W. Payne , Paul Talalay
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , Y10S435/829
摘要： The present invention discloses a unique biologically pure culture of a microorganism belonging to Alcaligenes species. The microorganism has the property of producing novel 17.beta.-hydroxysteroid dehydrogenase (17.beta.-HSD) capable of enzymatic reaction with an androgen and an estrogen. The methods of isolation the microorganism and the 17.beta.-HSD have been described. An assay and a kit for detecting the presence of C.sub.18 and C.sub.19 steroids in biological samples have also been disclosed.
摘要翻译： 本发明公开了属于产碱杆菌属的微生物的独特的生物纯培养物。 该微生物具有产生能够与雄激素和雌激素进行酶反应的新型17β-羟基类固醇脱氢酶（17β-HSD）的性质。 已经描述了分离微生物和17β-HSD的方法。 还已经公开了用于检测生物样品中C18和C19类固醇的存在的测定和试剂盒。
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