公开(公告)号：US5411986A

公开(公告)日：1995-05-02

申请号：US030610

申请日：1993-03-12

Applicant: Cheon-Gyu Cho ,  Gary H. Posner ,  Paul Talalay ,  Yuesheng Zhang

Inventor： Cheon-Gyu Cho ,  Gary H. Posner ,  Paul Talalay ,  Yuesheng Zhang

IPC: A61K31/145 ,  A61K31/26 ,  A61K31/66 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07C331/28 ,  C07F9/40 ,  C07C331/04

CPC classification number: C07C331/28 ,  A61K31/145 ,  A61K31/26 ,  A61K31/66 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07F9/4006

Abstract: Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.

公开(公告)号：US4709030A

公开(公告)日：1987-11-24

申请号：US884571

申请日：1986-07-11

Applicant: Martin Petrzilka ,  Martin Schadt

Inventor： Martin Petrzilka ,  Martin Schadt

IPC: C07C1/00 ,  C07C2/86 ,  C07C13/28 ,  C07C15/12 ,  C07C17/00 ,  C07C17/26 ,  C07C25/18 ,  C07C41/00 ,  C07C43/184 ,  C07C43/205 ,  C07C67/00 ,  C07C69/74 ,  C07C69/76 ,  C07C253/00 ,  C07C255/46 ,  C07C255/50 ,  C07C255/55 ,  C07C255/57 ,  C07C325/00 ,  C07C331/26 ,  C07C331/28 ,  C07D239/34 ,  C07D319/06 ,  C08L25/18 ,  C09K19/12 ,  C09K19/14 ,  C09K19/20 ,  C09K19/30 ,  C09K19/34 ,  C09K19/42 ,  C09K19/46 ,  G02F1/13 ,  G09F9/35

CPC classification number: C07C255/00 ,  C07C13/28 ,  C07C331/28 ,  C09K19/12 ,  C09K19/14 ,  C09K19/2007 ,  C09K19/3001 ,  C09K19/3402 ,  C09K19/3469 ,  C09K19/42 ,  C09K2019/3422

Abstract: Liquid crystalline mixtures containing compounds of the formula ##STR1## wherein n stands for the number 0 or 1; X.sup.1 and X.sup.2 denote single covalent bonds or one of the symbols X.sup.1 and X.sup.2 also denotes --COO--, --OOC-- or --CH.sub.2 CH.sub.2 --; the rings A.sup.1, A.sup.2 and A.sup.3 represent 1,4-phenylene, 2-fluoro-1,4-phenylene or trans-1,4-cyclohexylene or one of these rings also represents a 2,5-disubstituted pyrimidine ring or a trans-2,5-disubstituted m-dioxane ring; R.sup.1 signifies 4-alkenyl or on a cyclohexyl ring also 2Z-alkenyl; and R.sup.2 denotes alkyl, alkoxy, --CN or --NCS,as well as the manufacture of these compounds and the use for electro-optical purposes are described.

Abstract translation: 含有下式化合物的液晶混合物其中n代表数字0或1; X1和X2表示单个共价键，或者X1和X2之一也表示-COO-，-OOC-或-CH2CH2-; 环A1，A2和A3表示1,4-亚苯基，2-氟-1,4-亚苯基或反式-1,4-亚环己基，或这些环中的一个也表示2,5-二取代的嘧啶环或反式-1,4-亚环己基， 2,5-二取代的m-二恶烷环; R1表示4-链烯基或环己基环，也表示2Z-烯基; 并且R2表示烷基，烷氧基，-CN或-NCS，以及这些化合物的制造和电光目的的用途。

公开(公告)号：US3993677A

公开(公告)日：1976-11-23

申请号：US628030

申请日：1975-11-03

Applicant: Goro Asato

Inventor： Goro Asato

IPC: A61K31/26 ,  A23K20060101 ,  A23K1/16 ,  A61P3/00 ,  C07C20060101 ,  C07C67/00 ,  C07C241/00 ,  C07C265/10 ,  C07C325/00 ,  C07C331/26 ,  C07C119/048 ,  C07C161/04

CPC classification number: C08G18/757

Abstract: This invention relates to 1,2,3,4-tetrahydro-4-oxo-1-naphthylisocyanate and- isothiocyanate and to methods of preparation of said compounds.The compounds of the present invention are useful as intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo(oxy)-1-naphthylurea and- thiourea compounds and certain derivatives thereof. The naphthylurea and thiourea compounds are animal growth regulators and herbicides.

Abstract translation: 本发明涉及1,2,3,4-四氢-4-氧代-1-萘基异氰酸酯和异硫氰酸酯以及所述化合物的制备方法。

公开(公告)号：US20210070730A1

公开(公告)日：2021-03-11

申请号：US16957482

申请日：2018-10-08

Applicant: INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.

Inventor： Simona Rapposelli ,  Simona Sestito ,  Vincenzo Calderone ,  Guido Puricelli

IPC: C07D339/04 ,  C07C331/26 ,  A61K31/26 ,  A61K31/385 ,  A61K31/13

Abstract: The present invention concerns the field of neurodegenerative diseases, and in particular relates to compounds, pharmaceutical compositions and their uses in the protection of neuronal cells from inflammation and from oxidative stress in the early stage of Parkinson's Disease as well as in Alzheimer's Disease.

公开(公告)号：US20170114050A1

公开(公告)日：2017-04-27

申请号：US15311817

申请日：2015-05-13

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Michael Malamas ,  Alexandros Makriyannis ,  Kumara Vadivel Subramanian ,  Kyle M. Whitten ,  Nikolai M. Zvonok ,  Jay Matthew West ,  Michael Mccormack ,  Spiro Pavlopoulos

IPC: C07D405/12 ,  C07C331/20 ,  C07D213/36 ,  C07D295/13 ,  C07D295/135 ,  C07D211/26 ,  C07D241/18 ,  C07D239/26 ,  C07C331/26 ,  C07D319/18 ,  C07D317/54 ,  C07D213/64 ,  C07D213/30 ,  C07D261/08 ,  C07D231/12 ,  C07D317/58 ,  C07D205/04 ,  C07D413/12 ,  C07D403/12 ,  C07D207/12 ,  C07D211/46 ,  C07C255/46 ,  C07D239/28 ,  C07C331/24

CPC classification number: C07D405/12 ,  C07B2200/07 ,  C07C255/46 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D205/04 ,  C07D207/12 ,  C07D211/10 ,  C07D211/26 ,  C07D211/46 ,  C07D213/30 ,  C07D213/36 ,  C07D213/46 ,  C07D213/64 ,  C07D231/12 ,  C07D239/26 ,  C07D239/28 ,  C07D241/18 ,  C07D261/08 ,  C07D295/13 ,  C07D295/135 ,  C07D317/54 ,  C07D317/58 ,  C07D319/18 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.

公开(公告)号：USRE36784E

公开(公告)日：2000-07-18

申请号：US850387

申请日：1997-05-02

Applicant: Cheon-Gyu Cho ,  Gary H. Posner ,  Paul Talalay ,  Yuesheng Zhang

Inventor： Cheon-Gyu Cho ,  Gary H. Posner ,  Paul Talalay ,  Yuesheng Zhang

IPC: A61K31/145 ,  A61K31/26 ,  A61K31/66 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07C331/28 ,  C07F9/40 ,  A61K38/43 ,  C07C331/04

CPC classification number: C07C331/28 ,  A61K31/145 ,  A61K31/26 ,  A61K31/66 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07F9/4006

Abstract: Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.

Abstract translation: 已经分离出了萝卜硫烷，并将其鉴定为西兰花中的主要且非常有效的II期酶诱导剂（Brassica oleracea italica）。 Sulforaphane是单功能诱导剂，不依赖于芳基受体依赖的细胞色素P-450（I期酶）的诱导而选择性地诱导II期酶。 合成了硫的氧化态和亚甲基数的不同的类似物，测定了它们的诱导效力。 磺吡烟是这些类似物中最有效的。 还合成了具有不同取代基的其他类似物代替萝卜硫代甲基亚磺酰基，并进行了评估。 其中最有效的是6-异硫氰酸根合-2-己酮和外-2-乙酰基-6-异硫氰基降冰片烷。

公开(公告)号：US2411869A

公开(公告)日：1946-12-03

申请号：US55755444

申请日：1944-10-06

Applicant: RESINOUS PROD & CHEMICAL CO

Inventor： BRUSON HERMAN A

IPC: C07C17/30 ,  C07C41/30 ,  C07C43/188 ,  C07C43/215 ,  C07C43/225 ,  C07C43/23 ,  C07C49/553 ,  C07C331/26 ,  C07D317/50

CPC classification number: C07D317/50 ,  C07C17/30 ,  C07C41/30 ,  C07C43/188 ,  C07C43/215 ,  C07C43/225 ,  C07C43/23 ,  C07C49/553 ,  C07C331/26 ,  C07C2601/14 ,  C07C2602/44 ,  C07C23/30

公开(公告)号：US20180222894A1

公开(公告)日：2018-08-09

申请号：US15942345

申请日：2018-03-30

Applicant: Northeastern University

Inventor： Michael Malamas ,  Alexandros Makriyannis ,  Kumara Vadivel Subramanian ,  Kyle M. Whitten ,  Nikolai M. Zvonok ,  Jay Matthew West ,  Michael McCormack ,  Spiro Pavlopoulos

IPC: C07D405/12 ,  C07D317/58 ,  C07D239/26 ,  C07D239/28 ,  C07D241/18 ,  C07D295/13 ,  C07D295/135 ,  C07D213/30 ,  C07D213/36 ,  C07D213/64 ,  C07D213/46 ,  C07D211/46 ,  C07D211/26 ,  C07D211/10 ,  C07D207/12 ,  C07D205/04 ,  C07D261/08 ,  C07D413/12 ,  C07D401/12 ,  C07D231/12 ,  C07D319/18 ,  C07D317/54 ,  C07D403/12 ,  C07C331/26 ,  C07C331/24 ,  C07C331/20 ,  C07C255/46

CPC classification number: C07D405/12 ,  C07B2200/07 ,  C07C255/46 ,  C07C331/20 ,  C07C331/24 ,  C07C331/26 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D205/04 ,  C07D207/12 ,  C07D211/10 ,  C07D211/26 ,  C07D211/46 ,  C07D213/30 ,  C07D213/36 ,  C07D213/46 ,  C07D213/64 ,  C07D231/12 ,  C07D239/26 ,  C07D239/28 ,  C07D241/18 ,  C07D261/08 ,  C07D295/13 ,  C07D295/135 ,  C07D317/54 ,  C07D317/58 ,  C07D319/18 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).

公开(公告)号：US20040242905A1

公开(公告)日：2004-12-02

申请号：US10854676

申请日：2004-05-27

Inventor： Eike Poetsch ,  Werner Binder ,  Volker Meyer ,  Stephen Gurtler ,  Juergen Eckstein ,  Michael Schwarz

IPC: C07C331/28 ,  C07C331/26 ,  C07C255/40 ,  C07C069/95 ,  C07C047/28

CPC classification number: C09K19/3402 ,  C07C45/004 ,  C07C45/41 ,  C07C45/44 ,  C07C47/277 ,  C07C47/47 ,  C07C47/575 ,  C07C2601/14 ,  C07D319/06 ,  C09K19/0403 ,  C09K19/20 ,  C09K19/3066 ,  C09K19/32 ,  C09K2019/0444 ,  C09K2019/0466 ,  C09K2019/3422 ,  C07C47/22

Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula I OHC-(A11)m-Z11-(A12-Z12)n-(A13-Z13)p-A14 nullnullI and the use and preparation thereof and the preparation of 1,3-dioxane compounds.

Abstract translation: 含有通式I OHC-（A 11）mZ 11 - （A 12 -Z 12）n-（A 13 -Z 13）p A的二氟亚甲基桥的醛 并且其使用和制备以及1,3-二恶烷化合物的制备。

公开(公告)号：US5084204A

公开(公告)日：1992-01-28

申请号：US269327

申请日：1988-11-10

Applicant: Volker Reiffenrath ,  Joachim Krause ,  Georg Weber

Inventor： Volker Reiffenrath ,  Joachim Krause ,  Georg Weber

IPC: C07C1/00 ,  C07C13/28 ,  C07C13/44 ,  C07C13/48 ,  C07C15/50 ,  C07C15/54 ,  C07C15/58 ,  C07C17/00 ,  C07C17/08 ,  C07C17/25 ,  C07C17/263 ,  C07C25/24 ,  C07C41/00 ,  C07C43/18 ,  C07C43/20 ,  C07C43/215 ,  C07C45/00 ,  C07C49/00 ,  C07C67/00 ,  C07C69/007 ,  C07C69/773 ,  C07C253/00 ,  C07C255/55 ,  C07C325/00 ,  C07C331/26 ,  C07C331/28 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  G02F1/137 ,  G02F1/139

CPC classification number: C07C43/215 ,  C07C13/28 ,  C07C15/58 ,  C09K19/322 ,  C07C2101/14 ,  C09K2019/325

Abstract: Naphthylacetylenes of the formula IR.sup.1 --(A.sup.1 --Z.sup.1).sub.m --A.sup.2 --C.tbd.C--A.sup.3 --(Z.sup.2 --A.sup.4).sub.n --R.sup.2 Iin which R.sup.1, A.sup.1, Z.sup.1, m, A.sup.2, A.sup.3, Z.sup.2, A.sup.4, n and R.sup.2 have the meanings described herein, are suitable as components of liquid crystal phases.

Abstract translation: 式I R1-（A1-Z1）m-A2-C 3BOND C-A3-（Z2-A4）n-R2 I的萘基乙炔其中R1，A1，Z1，m，A2，A3，Z2，A4，n 和R2具有本文所述的含义，适合作为液晶相的组分。