Deprotection method for tetrazole compound
    29.
    发明授权
    Deprotection method for tetrazole compound 有权
    四唑化合物脱保护方法

    公开(公告)号:US09527821B2

    公开(公告)日:2016-12-27

    申请号:US14429257

    申请日:2013-09-26

    申请人: API CORPORATION

    发明人: Masahiko Seki

    摘要: The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers.Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Brønsted acid: wherein each symbol is as defined in the present specification.

    摘要翻译: 本发明涉及一种用作血管紧张素II受体阻断剂中间体的四唑化合物脱保护方法,提供血管紧张素II受体阻断剂的新型制备方法。 本发明提供由式[3]或[4]表示的化合物或其盐的制备方法,其包括(i)在式(1)或[2]表示的化合物或其盐的存在下,还原式 金属催化剂和碱土金属盐,或(ii)使化合物与特定量的布朗斯台德酸反应:其中每个符号如本说明书中所定义。