公开(公告)号：US20150239853A1

公开(公告)日：2015-08-27

申请号：US14424912

申请日：2013-08-30

申请人： API CORPORATION

发明人： Masahiko Seki

IPC分类号： C07D257/04 ,  C07D405/14 ,  C07D403/10

CPC分类号： C07D257/04 ,  C07B37/04 ,  C07D403/10 ,  C07D405/14

摘要： The invention provides a production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by RAxP(O)(OM)y wherein each symbol is as defined herein.

摘要翻译： 本发明提供式[3]的联芳基化合物或其盐的制备方法，包括使式[1]的2-苯基唑衍生物或其盐与式[2]的苯衍生物或 （a）一元羧酸金属盐，（b）二羧酸金属盐，（c）磺酸金属盐和（d）一种或多种金属催化剂，碱， 由RAxP（O）（OM）y表示的磷酸酯或磷酰胺金属盐，其中每个符号如本文所定义。

公开(公告)号：US20150239854A1

公开(公告)日：2015-08-27

申请号：US14429257

申请日：2013-09-26

申请人： API CORPORATION

发明人： Masahiko Seki

IPC分类号： C07D257/04 ,  C07D403/10 ,  B01J23/58 ,  C07D405/14

CPC分类号： C07D257/04 ,  B01J23/58 ,  C07D403/10 ,  C07D405/14

摘要： The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers.Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Brønsted acid: wherein each symbol is as defined in the present specification.

摘要翻译： 本发明涉及一种用作血管紧张素II受体阻断剂中间体的四唑化合物脱保护方法，提供血管紧张素II受体阻断剂的新型制备方法。 本发明提供由式[3]或[4]表示的化合物或其盐的制备方法，其包括（i）在式（1）或[2]表示的化合物或其盐的存在下，还原式 金属催化剂和碱土金属盐，或（ii）使化合物与特定量的布朗斯台德酸反应：其中每个符号如本说明书中所定义。

公开(公告)号：US09624181B2

公开(公告)日：2017-04-18

申请号：US14424912

申请日：2013-08-30

申请人： API CORPORATION

发明人： Masahiko Seki

IPC分类号： C07D257/04 ,  C07D405/14 ,  C07D403/10 ,  C07B37/04

CPC分类号： C07D257/04 ,  C07B37/04 ,  C07D403/10 ,  C07D405/14

摘要： The invention provides a production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by RAxP(O)(OM)y wherein each symbol is as defined herein.

公开(公告)号：US09527821B2

公开(公告)日：2016-12-27

申请号：US14429257

申请日：2013-09-26

申请人： API CORPORATION

发明人： Masahiko Seki

IPC分类号： C07D257/04 ,  C07D403/10 ,  C07D405/14 ,  B01J23/58

CPC分类号： C07D257/04 ,  B01J23/58 ,  C07D403/10 ,  C07D405/14

摘要： The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers.Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Brønsted acid: wherein each symbol is as defined in the present specification.

摘要翻译： 本发明涉及一种用作血管紧张素II受体阻断剂中间体的四唑化合物脱保护方法，提供血管紧张素II受体阻断剂的新型制备方法。 本发明提供由式[3]或[4]表示的化合物或其盐的制备方法，其包括（i）在式（1）或[2]表示的化合物或其盐的存在下，还原式 金属催化剂和碱土金属盐，或（ii）使化合物与特定量的布朗斯台德酸反应：其中每个符号如本说明书中所定义。