摘要:
The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via, e.g., the epidermal, dermal, or subcutaneous layer of the skin in a concentrated fours of injectable paste of slurry.
摘要:
Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those Components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.
摘要:
The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.
摘要:
A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
摘要:
A device for delivery of medicament, which device comprises an elongated housing; a container (4) mounted within said housing and adapted to contain liquid medicament; a stopper slidably arranged within said container; and actuating means comprising a resilient member (60), a driving means (50) having one end connected to the stopper and a second end being operably connected to the resilient member, retaining means (40) for releasably retaining said driving means in a first position where said resilient member has an accumulated energy, and activating means operably connected to said retaining means for releasing said driving means to a second position, upon actively operation by an user, such that said accumulated energy is transferred to the driving means for driving the stopper a predetermined distance within the container whereby the medicament within said container i delivered characterized in that the resilient member is a variable force spring adapted for generating a predetermined sequence of at least two different force profiles during the medicament delivery.
摘要:
A high-pressure fluid injection system, which includes a rechargeable injection chamber with a proximal end, a distal end, and an internal opening extending from the proximal end to the distal end, a plunger slideably engaged with the internal opening of the injection chamber, an injection tube extending from the distal end of the injection chamber and in fluidic communication with the internal opening of the injection chamber, and a check valve between the proximal and distal ends of the injection chamber. The internal opening includes a high-pressure zone adjacent to the check valve and having a first diameter, and a low-pressure zone proximal to the high-pressure zone and having a second diameter that is larger than the first diameter.
摘要:
A lock for an injection device including a threaded rod, wherein the lock includes one of an anti-rotation or claw-type securing element engageable in cooperative anti-rotation elements or claws of the injection device to prevent rotation of the threaded rod relative to the injection device.
摘要:
The present invention relates to a medical delivery device comprising a tubular distal housing; a tubular proximal housing; a medicament container arranged inside said tubular proximal housing; a threaded hollow plunger rod; a spring force means pre-tensioned arranged within said plunger rod; activation means arranged to be movable between a non-medicament delivery state and a medicament delivery state; dose setting means being threadedly arranged to said threaded hollow plunger rod and arranged to be rotationally moved between a stop position and a set dose position, whereby upon activation of said activation means from the non-medicament delivery state to the medicament delivery state, said threaded hollow plunger rod is linearly displaced due to the force of the pre-tensioned spring means such that the dose setting means is also linearly displaced from the set dose position to the stop position.
摘要:
A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
摘要:
A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.