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公开(公告)号：US09707351B2
公开(公告)日：2017-07-18
申请号：US13878463
申请日：2011-10-11
Applicant: David Martin Leak , Joseph Butler
Inventor： David Martin Leak , Joseph Butler
IPC: A61M5/315
CPC classification number: A61M5/31528 , A61M5/31525 , A61M5/31538 , A61M5/31551 , A61M5/31571 , A61M5/31585
Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.
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公开(公告)号：US09089645B2
公开(公告)日：2015-07-28
申请号：US13885322
申请日：2011-11-28
Applicant: David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
Inventor： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
CPC classification number: A61M5/19 , A61M5/002 , A61M5/20 , A61M5/31545 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/31563 , A61M5/31575 , A61M5/31585 , A61M5/34 , A61M2005/1787 , A61M2005/202 , A61M2005/2474
Abstract: A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
Abstract translation: 具有固定剂量设定机构的药物输送装置，具有偏置元件。 药物递送装置包括第一剂量设定机构，其中第一剂量设定机构可操作地连接到容纳第一药剂的主贮存器。 该装置还包括可操作地耦合到第一剂量设定机构的剂量设定器。 该装置还包括第二剂量设定机构，其中第二剂量设定机构可操作地连接到容纳第二药剂的二级容器。 第二剂量设定机构与第一剂量设定机构机械连接，第二剂量设定机构包括偏置元件。 剂量设定器被配置为设置第一药剂的可变剂量并且在活化时自动设定固定剂量的第二药剂。 另外，偏置元件构造成辅助分配第二药剂。
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公开(公告)号：US20130296802A1
公开(公告)日：2013-11-07
申请号：US13878762
申请日：2011-10-11
Applicant: David Moore , Joseph Butler , David Martin Leak
Inventor： David Moore , Joseph Butler , David Martin Leak
IPC: A61M5/315
CPC classification number: A61M5/31535 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/31585
Abstract: A dose setting mechanism comprises a drug delivery device housing and a dual state track provided within the housing that is axially and rotationally fixed with respect to the housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A clutch is rotatable during dose setting and non-rotatable during dose delivery. A clutch plate is rotationally fixed relative to the housing; and a clutch blocker is in threaded engagement with the clutch plate and has a radial key engaged with the dual state track. The mechanism may comprise a biasing member positioned between the clutch blocker and clutch plate.
Abstract translation: 剂量设定机构包括药物输送装置壳体和设置在壳体内的相对于壳体轴向和旋转地固定的双状态轨道。 剂量拨号组件定位在壳体中并且可以在剂量设定和剂量递送期间旋转。 离合器在剂量设定期间是可旋转的，并且在剂量递送期间不能旋转。 离合器板相对于壳体旋转地固定; 并且离合器阻挡件与离合器板螺纹接合并且具有与双状态轨道接合的径向键。 该机构可以包括定位在离合器阻挡件和离合器板之间的偏置构件。
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公开(公告)号：US20130267908A1
公开(公告)日：2013-10-10
申请号：US13885322
申请日：2011-11-28
Applicant: David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
Inventor： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
IPC: A61M5/19
CPC classification number: A61M5/19 , A61M5/002 , A61M5/20 , A61M5/31545 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/31563 , A61M5/31575 , A61M5/31585 , A61M5/34 , A61M2005/1787 , A61M2005/202 , A61M2005/2474
Abstract: A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
Abstract translation: 具有固定剂量设定机构的药物输送装置，具有偏置元件。 药物递送装置包括第一剂量设定机构，其中第一剂量设定机构可操作地连接到容纳第一药剂的主贮存器。 该装置还包括可操作地耦合到第一剂量设定机构的剂量设定器。 该装置还包括第二剂量设定机构，其中第二剂量设定机构可操作地连接到容纳第二药剂的二级容器。 第二剂量设定机构与第一剂量设定机构机械连接，第二剂量设定机构包括偏置元件。 剂量设定器被配置为设置第一药剂的可变剂量并且在活化时自动设定固定剂量的第二药剂。 另外，偏置元件构造成辅助分配第二药剂。
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公开(公告)号：US09517308B2
公开(公告)日：2016-12-13
申请号：US13878762
申请日：2011-10-11
Applicant: David Moore , Joseph Butler , David Martin Leak
Inventor： David Moore , Joseph Butler , David Martin Leak
CPC classification number: A61M5/31535 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/31585
Abstract: A dose setting mechanism comprises a drug delivery device housing and a dual state track provided within the housing that is axially and rotationally fixed with respect to the housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A clutch is rotatable during dose setting and non-rotatable during dose delivery. A clutch plate is rotationally fixed relative to the housing; and a clutch blocker is in threaded engagement with the clutch plate and has a radial key engaged with the dual state track. The mechanism may comprise a biasing member positioned between the clutch blocker and clutch plate.
Abstract translation: 剂量设定机构包括药物输送装置壳体和设置在壳体内的相对于壳体轴向和旋转地固定的双状态轨道。 剂量拨号组件定位在壳体中并且可以在剂量设定和剂量递送期间旋转。 离合器在剂量设定期间是可旋转的，并且在剂量递送期间不能旋转。 离合器板相对于壳体旋转地固定; 并且离合器阻挡件与离合器板螺纹接合并且具有与双状态轨道接合的径向键。 该机构可以包括定位在离合器阻挡件和离合器板之间的偏置构件。
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Patent Agency Ranking
公开(公告)号：US09457142B2
公开(公告)日：2016-10-04
申请号：US13509603
申请日：2010-11-29
Applicant: Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
Inventor： Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
CPC classification number: A61M5/19 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31546 , A61M5/31583 , A61M5/3202 , A61M5/3294 , A61M5/3295 , A61M5/347 , A61M2005/2407 , A61M2005/2411 , A61M2005/2496 , A61M2005/3126 , A61M2005/31518 , A61M2005/31588 , A61M2205/14 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206
Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.
Abstract translation: 构造成递送至少一剂两种或更多种药物的计算机化机电药物递送装置。 该装置包括控制单元。 机电驱动单元可操作地联接到控制单元和用于第一药剂的主容器和用于流体试剂的第二储存器，例如液体。 第二种药物。 操作员界面与控制单元通信。 单个分配组件被配置为与初级和次级容器流体连通。 操作面板的激活设定来自主贮存器的第一剂量，并且基于第一剂量和治疗剂量分布，该控制单元构造成确定流体试剂的剂量或范围。 或者，控制单元确定或计算第三药剂的剂量或范围。 此外，公开了一种用于药物输送装置的分配界面。
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公开(公告)号：US09402961B2
公开(公告)日：2016-08-02
申请号：US13885326
申请日：2011-11-28
Applicant: David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
Inventor： David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
CPC classification number: A61M5/31548 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31585 , A61M5/31593 , A61M2005/202
Abstract: A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose.
Abstract translation: 具有提供分配辅助的弹簧元件的药物递送装置。 药物递送装置包括可变剂量设定机构，固定剂量设定机构和具有弹簧元件的机械联接器。 可变剂量设定机构可操作地耦合到保持第一药物的第一储存器，并且可变剂量设定机构包括剂量设定器。 固定剂量设定机构可操作地联接到容纳第二药剂的第二储存器。 机械耦合可操作地耦合可变剂量设定机构和固定剂量设定机构。 此外，可变剂量设定机构被配置为在激活剂量设定器时设定第一药剂的可变剂量，并且固定剂量设定机构被配置为在可变剂量设定期间设定第二药剂的固定剂量。 此外，弹簧元件构造成在剂量设定期间储存能量并将储存的能量转移到固定剂量设定机构以帮助分配固定剂量。
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公开(公告)号：US09248239B2
公开(公告)日：2016-02-02
申请号：US13885324
申请日：2011-11-28
Applicant: David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
Inventor： David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
CPC classification number: A61M5/3155 , A61M5/19 , A61M5/31596 , A61M2005/3142
Abstract: A drug delivery device for co-delivery of two medicaments. The drug delivery device has a dose setter, a first dose dial component, a second dose dial component, and a collar. The first dose dial component is configured to select a first dose of a first medicament, and the first dose dial component is operably connected to the dose setter. The second dose dial component is configured to select a second dose of a second medicament. In addition, the first dose dial component and the second dose dial component are connected to the collar. The collar is configured to be moved in a proximal direction by actuation of the dose setter. Further, when the collar is moved in a proximal direction, the first dose dial component and the second dose dial component are configured to move proximally to set a dose “A” for the first medicament with the first dose dial component and set a dose “B” for the second medicament with the second dose dial component.
Abstract translation: 用于共同递送两种药物的药物递送装置。 药物递送装置具有剂量设定器，第一剂量拨号部件，第二剂量拨号部件和衣领。 第一剂量拨号组件被配置为选择第一药剂的第一剂量，并且第一剂量拨号组件可操作地连接到剂量设定器。 第二剂量拨号组件配置成选择第二剂量的第二药剂。 此外，第一剂量拨号组件和第二剂量拨号组件连接到衣领。 套环构造成通过致动剂量设定器在近端方向上移动。 此外，当套环沿近端方向移动时，第一剂量拨盘部件和第二剂量拨盘部件构造成向近侧移动以针对具有第一剂量拨号部件的第一药物设定剂量“A”并设定剂量“ B“用于具有第二剂量拨号组件的第二药物。
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公开(公告)号：US09789259B2
公开(公告)日：2017-10-17
申请号：US13994628
申请日：2011-12-16
Applicant: Joseph Butler , David Martin Leak
Inventor： Joseph Butler , David Martin Leak
CPC classification number: A61M5/31551 , A61M5/24 , A61M5/31541 , A61M5/31561 , A61M5/31568 , A61M5/31585 , A61M2205/581 , A61M2205/582
Abstract: A dose setting mechanism for a drug delivery device is provided comprising a dose setting member and a further element. Maximum dose stop features are provided on a housing and on the further element.
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10.发明授权Delivery of two or more medicaments through a single dose selection and dispense interface 有权通过单剂量选择和分配界面递送两种或更多种药物公开(公告)号：US09592342B2
公开(公告)日：2017-03-14
申请号：US13375525
申请日：2010-06-01
Applicant: Daniel Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
Inventor： Daniel Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
CPC classification number: A61M5/2448 , A61M5/2455 , A61M5/31551 , A61M5/31561 , A61M5/3294 , A61M2005/1787 , A61M2005/3142
Abstract: An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).
Abstract translation: 一种用于共同递送具有药物输送装置（2）的两种药物（1,2）的注射系统，所述药物输送装置（7）包含含有第一药剂（1）并具有第二储存器（5,17,30）的主储存器， 第二药物（2），其中药物递送装置（7）仅具有用于主储存器（11）的一个剂量设定器（12）并且自动确定第二药剂（2）的剂量。 两种药物（1,2）都通过一个分配界面（3,16,21,31）进行输送。
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