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    Phosphaplatin mediated modulation of pigment epithelial derived factor and uses thereof
    22.
    发明授权
    Phosphaplatin mediated modulation of pigment epithelial derived factor and uses thereof 有权
    磷酸化蛋白介导的色素上皮衍生因子的调节及其用途

    公开(公告)号：US09333211B2

    公开(公告)日：2016-05-10

    申请号：US14186245

    申请日：2014-02-21

    申请人： Rathindra N. Bose ,  Shadi Moghaddas ,  Homa Dezvareh

    发明人： Rathindra N. Bose ,  Shadi Moghaddas ,  Homa Dezvareh

    IPC分类号： A61K31/675 ,  A61K31/555 ,  A61K31/6615 ,  A61K45/06 ,  A61K31/255 ,  A61K31/337 ,  A61K31/427 ,  A61K31/519 ,  A61K31/69 ,  A61K33/24

    CPC分类号： A61K31/6615 ,  A61K31/255 ,  A61K31/337 ,  A61K31/427 ,  A61K31/519 ,  A61K31/555 ,  A61K31/675 ,  A61K31/69 ,  A61K33/24 ,  A61K45/06 ,  A61N5/10 ,  A61K2300/00

    摘要： The present disclosure provides for compositions for the treatment of neurodegenerative diseases comprising one or more isolated phosphate complexes of platinum and methods of uses thereof for treating neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer's disease, stroke, epilepsy, Parkinsons, Huntington's disease and diabetes associated peripheral neuropathy The present disclosure is also directed towards an anti-angiogenic composition useful for inhibiting angiogenesis related to age-related macular degeneration, diabetic retinopathy and tumor-associated angiogenesis. An embodiment of the present disclosure is also directed towards a method for modulating the expression of Pigment Epithelial Derived Factor (PEDF) gene in an individual in need thereof. The present disclosure also provides for a method of reducing neurotoxicity associated with the administration of a cancer therapy in a subject in need thereof comprising administering to the individual in need thereof a therapeutically effective amount of at least one or more isolated monomeric phosphate complexes of platinum described herein.

    摘要翻译： 本公开内容提供用于治疗包含一种或多种分离的铂的磷酸复合物的神经变性疾病的组合物及其用于治疗神经变性疾病的用途的方法，所述神经变性疾病包括肌萎缩性侧索硬化，阿尔茨海默氏病，中风，癫痫，帕金森氏症，亨廷顿病和糖尿病相关外周 神经病变本发明还涉及可用于抑制与年龄相关性黄斑变性，糖尿病性视网膜病变和肿瘤相关血管发生相关的血管生成的抗血管生成组合物。 本公开的实施方案还涉及用于调节有需要的个体中颜料上皮衍生因子（PEDF）基因表达的方法。 本公开还提供了减少与有需要的受试者相关的癌症治疗相关联的神经毒性的方法，包括向有需要的个体施用治疗有效量的至少一种或多种所分离的铂单体磷酸复合物 这里。

    Sulindac formulations in a biodegradable material
    23.
    发明授权
    Sulindac formulations in a biodegradable material 有权
    舒林酸配方可生物降解材料

    公开(公告)号：US09289409B2

    公开(公告)日：2016-03-22

    申请号：US12413236

    申请日：2009-03-27

    申请人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

    发明人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

    IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/255 ,  A61K9/00 ,  A61K9/20

    CPC分类号： A61K31/255 ,  A61K9/0024 ,  A61K9/204

    摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Use of propyl propane thiosulfinate and propyl propane thiosulfonate for the prevention and reduction of parasites in aquatic animals
    24.
    发明授权
    Use of propyl propane thiosulfinate and propyl propane thiosulfonate for the prevention and reduction of parasites in aquatic animals 有权
    丙基硫代亚磺酸丙酯和丙烷硫代磺酸丙酯用于预防和减少水生动物寄生虫的使用

    公开(公告)号：US09271947B2

    公开(公告)日：2016-03-01

    申请号：US14043160

    申请日：2013-10-01

    申请人： Investfood, LLC

    发明人： Cristina Núñez Lechado ,  Alberto Baños Arjona ,  Enrique Guillamón Ayala ,  Adela Valero López ,  Ma Concepción Navarro Moll ,  Ana Sanz Rus

    IPC分类号： A61K31/105 ,  A61K31/10 ,  A01N41/10 ,  A23K1/18 ,  A23K1/16 ,  A61K31/255

    CPC分类号： A61K31/10 ,  A01N41/10 ,  A23K20/10 ,  A23K50/80 ,  A61K31/255 ,  A61K2300/00

    摘要： A method for reducing parasites in aquatic animals is provided. The method includes reducing a plurality of parasites infecting an aquatic animal by administrating to the aquatic animal a compound comprising propyl propane thiosulfonate (PTSO) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 2. In yet a different embodiment, a method for reducing a plurality of parasites infecting an aquatic animal includes administrating to the aquatic animal a compound comprising and propyl propane thiosulfinate (PTS) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 1. In even yet another embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTS. In a different embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTSO.

    摘要翻译： 提供了一种减少水生动物寄生虫的方法。 该方法包括通过向水生动物施用包含具有式R-SO-S-R的丙基硫代磺酸丙酯（PTSO）的化合物来减少感染水生动物的多种寄生虫，其中R表示正丙基（-CH 2 -CH 2 -CH 3）和a为2.在另一个不同的实施方案中，减少感染水生动物的多种寄生虫的方法包括向水生动物施用包含具有式R-SOa-S的丙烷次硫酸亚丙酯（PTS）的化合物 -R，其中R表示正丙基（-CH 2 -CH 2 -CH 3），a为1.在另一个实施方案中，提供了防止水生动物中多种寄生虫的方法，包括向水生动物施用 化合物包括PTS。 在不同的实施方案中，提供了一种用于在水生动物中预防多种寄生虫的方法，包括向水生动物施用包括PTSO的化合物。

    USE OF PROPYL PROPANE THIOSULFINATE AND PROPYL PROPANE THIOSULFONATE FOR THE PREVENTION AND REDUCTION OF PARASITES IN AQUATIC ANIMALS
    30.
    发明申请
    USE OF PROPYL PROPANE THIOSULFINATE AND PROPYL PROPANE THIOSULFONATE FOR THE PREVENTION AND REDUCTION OF PARASITES IN AQUATIC ANIMALS 有权
    丙磺酸丙磺酸和丙磺酸丙磺酸用于预防和减少水生动物中的寄生虫的使用

    公开(公告)号：US20150094381A1

    公开(公告)日：2015-04-02

    申请号：US14043160

    申请日：2013-10-01

    申请人： Investfood, LLC

    发明人： Cristina Núñez Lechado ,  Alberto Baños Arjona ,  Enrique Guillamón Ayala ,  Adela Valero López ,  Mª Concepción Navarro Moll ,  Ana Sanz Rus

    IPC分类号： A61K31/10

    CPC分类号： A61K31/10 ,  A01N41/10 ,  A23K20/10 ,  A23K50/80 ,  A61K31/255 ,  A61K2300/00

    摘要： A method for reducing parasites in aquatic animals is provided. The method includes reducing a plurality of parasites infecting an aquatic animal by administrating to the aquatic animal a compound comprising propyl propane thiosulfonate (PTSO) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 2. In yet a different embodiment, a method for reducing a plurality of parasites infecting an aquatic animal includes administrating to the aquatic animal a compound comprising and propyl propane thiosulfinate (PTS) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 1. In even yet another embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTS. In a different embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTSO.

    摘要翻译： 提供了一种减少水生动物寄生虫的方法。 该方法包括通过向水生动物施用包含具有式R-SO-S-R的丙基硫代磺酸丙酯（PTSO）的化合物来减少感染水生动物的多种寄生虫，其中R表示正丙基（-CH 2 -CH 2 -CH 3）和a为2.在另一个不同的实施方案中，减少感染水生动物的多种寄生虫的方法包括向水生动物施用包含具有式R-SOa-S的丙烷次硫酸亚丙酯（PTS）的化合物 -R，其中R表示正丙基（-CH 2 -CH 2 -CH 3），a为1.在另一个实施方案中，提供了防止水生动物中多种寄生虫的方法，包括向水生动物施用 化合物包括PTS。 在不同的实施方案中，提供了一种用于在水生动物中预防多种寄生虫的方法，包括向水生动物施用包括PTSO的化合物。