公开(公告)号：US20160266153A1

公开(公告)日：2016-09-15

申请号：US15067979

申请日：2016-03-11

Applicant: Randox Laboratories Limited

Inventor： Elouard Benchikh ,  Ivan McConnell ,  Peter Fitzgerald ,  Philip Lowry

IPC: G01N33/94 ,  C07K1/107 ,  C07K16/44 ,  C07K14/765 ,  C07K14/435

CPC classification number: G01N33/9426 ,  C07K1/1077 ,  C07K14/43504 ,  C07K14/765 ,  C07K16/44

Abstract: Antibodies, immunoassay methods and kits thereof are described for the detection and determination of 3-(aminomethyl)-5-methylhexanoic acid. The novel immunogens from which said antibodies are generated are also described.

Abstract translation: 描述了用于检测和测定3-（氨基甲基）-5-甲基己酸的抗体，免疫测定方法和试剂盒。 还描述了产生所述抗体的新型免疫原。

公开(公告)号：US20150126385A1

公开(公告)日：2015-05-07

申请号：US14361880

申请日：2012-12-03

Applicant: Randox Laboratories Ltd.

Inventor： John Lamont ,  Ivan Mc Connell ,  Peter Fitzgerald

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/70564 ,  G01N2333/7151 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/60

Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

Abstract translation: 本发明提供了用于诊断疑似患有中风的患者的中风的基于生物标志物的方法，并且还用于区分缺血性卒中和短暂性脑缺血发作。 还描述了包含用于本发明方法中的生物标志物的特定组合的探针的底物。

公开(公告)号：US20140099651A1

公开(公告)日：2014-04-10

申请号：US14048325

申请日：2013-10-08

Applicant: Randox Laboratories

Inventor： Ivan McConnell ,  Elouard Benchikh ,  Philip Lowry ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K16/44

CPC classification number: G01N33/94 ,  A61K47/643 ,  A61K47/646 ,  C07K16/44 ,  C07K2317/33

Abstract: The invention provides novel haptens and immunogens for the preparation of novel monoclonal antibodies, which detect the synthetic opioid meperidine and its active metabolite normeperidine. These antibodies enable methods and kits, which are useful in an immunoassay for therapeutic drug monitoring (TDM) and in extending the window of detection for cases of abuse and drug-facilitated sexual assault (DFSA).

Abstract translation: 本发明提供新型的半抗原和免疫原，用于制备新的单克隆抗体，其检测合成的阿片样哌啶及其活性代谢标准哌啶。 这些抗体使得方法和试剂盒可用于治疗药物监测（TDM）的免疫测定和延长滥用和药物促进性攻击（DFSA）检测窗口。

公开(公告)号：US20230406933A1

公开(公告)日：2023-12-21

申请号：US18035070

申请日：2021-11-02

Applicant: Randox Laboratories Ltd.

Inventor： Marshall Dunlop ,  Shirley Schon ,  John Lamont ,  Peter Fitzgerald

IPC: C07K16/28

CPC classification number: C07K16/2827 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/33 ,  C07K2317/22 ,  C07K2317/94 ,  C07K2317/76

Abstract: The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.

公开(公告)号：US20220412994A1

公开(公告)日：2022-12-29

申请号：US17775217

申请日：2020-11-06

Applicant: Randox Laboratories Ltd

Inventor： Paul Innocenzi ,  Mark Ruddock ,  John Lamont ,  Peter Fitzgerald

IPC: G01N33/68

Abstract: Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.

公开(公告)号：US20220193685A1

公开(公告)日：2022-06-23

申请号：US17602897

申请日：2020-04-08

Applicant: RANDOX LABORATORIES LTD

Inventor： Proinnsias McGleenan ,  P Evans ,  Stuart Jackson ,  Martin Reid ,  Peter Fitzgerald

IPC: B01L9/00

Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.

公开(公告)号：US10416175B2

公开(公告)日：2019-09-17

申请号：US15385063

申请日：2016-12-20

Applicant: Randox Laboratories Limited

Inventor： Ivan McConnell ,  Elouard Benchikh ,  Philip Lowry ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K16/44 ,  G01N33/543

Abstract: An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

公开(公告)号：US10253006B2

公开(公告)日：2019-04-09

申请号：US15130137

申请日：2016-04-15

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Elouard Benchikh ,  Ivan McConnell ,  Philip Lowry ,  Peter Fitzgerald

IPC: C07D295/155 ,  G01N33/53 ,  C07K14/47 ,  C07K14/765 ,  C07K16/44 ,  C07D295/096 ,  C07D241/04

Abstract: The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity.

公开(公告)号：USD815752S1

公开(公告)日：2018-04-17

申请号：US29510481

申请日：2014-11-28

Applicant: Randox Laboratories Ltd.

Designer： Stuart Jackson ,  Ivan McConnell ,  John Lamont ,  Peter Fitzgerald

公开(公告)号：US20180011115A1

公开(公告)日：2018-01-11

申请号：US15547608

申请日：2016-01-29

Applicant: Randox Laboratories Ltd.

Inventor： Mark W. Ruddock ,  Cherith N. Reid ,  Kate E. Williamson ,  John Lamont ,  Peter Fitzgerald

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2800/50 ,  G01N2800/709

Abstract: The present invention related to a method for detecting a history of exposure to a chemical(s) comprising measuring the concentration of thrombomodulin in a sample isolated from a subject, and determining whether the concentration of thrombomodulin is altered compared to control reference levels.