公开(公告)号：US20150175682A1

公开(公告)日：2015-06-25

申请号：US14390085

申请日：2013-03-15

Applicant: AC Immune S.A. ,  Katholieke Universiteit Leuven ,  Genentech, Inc.

Inventor： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren ,  Oskar Adolfsson ,  Fred Van Leuven ,  Gai Ayalon ,  Danielle Marie Di Cara ,  Isidro Hotzel

IPC: C07K16/18 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimer's Disease (AD).

Abstract translation: 本发明提供了用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结相关的疾病和病症的终端复合材料的方法。 特别地，本发明涉及人源化抗体，其特异性识别并结合磷酸化病理蛋白质tau构象体，涉及用于治疗和诊断用途的抗体的方法和组合物用于治疗包括阿尔茨海默氏病（AD）在内的tau蛋白病。

公开(公告)号：US20150098946A1

公开(公告)日：2015-04-09

申请号：US14400684

申请日：2013-03-14

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Meredith Hazen ,  Jo-Anne S Hongo ,  Jagath R Junutula ,  Isidro Hotzel ,  Yonglei Shang ,  Shang-Fan Yu

IPC: C07K16/30 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415 ,  G01N33/57423 ,  G01N2333/47 ,  G01N2500/02

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。

公开(公告)号：US11555065B2

公开(公告)日：2023-01-17

申请号：US17110969

申请日：2020-12-03

Applicant: Genentech, Inc. ,  AC Immune SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20210332114A1

公开(公告)日：2021-10-28

申请号：US17110969

申请日：2020-12-03

Applicant: Genentech, Inc. ,  AC Immune SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US10711058B2

公开(公告)日：2020-07-14

申请号：US16420673

申请日：2019-05-23

Applicant: AC Immune SA ,  Genentech, Inc.

Inventor： Oskar Adolfsson ,  Isidro Hotzel ,  Danielle DiCara

IPC: C07K16/18 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  G01N33/577 ,  A61K39/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20190112362A1

公开(公告)日：2019-04-18

申请号：US16140189

申请日：2018-09-24

Applicant: GENENTECH, INC. ,  AC IMMUNE SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US09803191B2

公开(公告)日：2017-10-31

申请号：US13934570

申请日：2013-07-03

Applicant: Genentech, Inc.

Inventor： Devin Tesar ,  Xiaocheng Chen ,  Mark Dennis ,  Isidro Hotzel

IPC: C12N15/10 ,  C12N15/74 ,  C12N15/70 ,  C07K16/00 ,  C12N15/85 ,  C12P21/02

CPC classification number: C12N15/1037 ,  C07K16/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85 ,  C12P21/02

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.

公开(公告)号：US20160024193A1

公开(公告)日：2016-01-28

申请号：US14773332

申请日：2014-03-12

Applicant: AC IMMUNE S.A. ,  GENENTECH INC.

Inventor： Gai Ayalon ,  Danielle Marie Di Cara ,  Isidro Hotzel ,  Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren ,  Oskar Adolfsson

IPC: C07K16/18 ,  A61K47/48

CPC classification number: C07K16/18 ,  A61K47/6843 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.

Abstract translation: 本发明涉及抗Tau抗体，例如以高特异性和/或亲和力结合人Tau蛋白上的磷酸化表位的抗体及其使用方法。

公开(公告)号：US20150376265A1

公开(公告)日：2015-12-31

申请号：US14577991

申请日：2014-12-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Becket L. Feierbach ,  Ashley Fouts ,  Isidro Hotzel ,  Bing Li ,  Jo-Anne S. Hongo ,  Rajesh Vij

IPC: C07K16/08 ,  A61K45/06 ,  A61K39/42

CPC classification number: C07K16/088 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides compositions comprising anti-gH antibodies and anti-Complex I antibodies as well as methods of using the same.

Abstract translation: 本发明提供了包含抗-GH抗体和抗复合物I抗体的组合物以及使用该组合物的方法。

公开(公告)号：US20140011981A1

公开(公告)日：2014-01-09

申请号：US13934570

申请日：2013-07-03

Applicant: Genentech, Inc.

Inventor： Devin Tesar ,  Xiaocheng Chen ,  Mark Dennis ,  Isidro Hotzel

IPC: C12N15/10 ,  C07K16/00 ,  C12P21/02 ,  C12N15/70 ,  C12N15/85

CPC classification number: C12N15/1037 ,  C07K16/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85 ,  C12P21/02

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.

Abstract translation: 本发明提供了表达和分泌系统及其使用方法，用于在真核细胞中的原核细胞和第二融合蛋白中表达和分泌一种融合蛋白。 本文还提供了包含这种载体和核酸分子的核酸分子，载体和宿主细胞。