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公开(公告)号：US20160024193A1
公开(公告)日：2016-01-28
申请号：US14773332
申请日：2014-03-12
Applicant: AC IMMUNE S.A. , GENENTECH INC.
Inventor： Gai Ayalon , Danielle Marie Di Cara , Isidro Hotzel , Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson
CPC classification number: C07K16/18 , A61K47/6843 , C07K16/44 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92
Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.
Abstract translation: 本发明涉及抗Tau抗体，例如以高特异性和/或亲和力结合人Tau蛋白上的磷酸化表位的抗体及其使用方法。
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公开(公告)号：US09598485B2
公开(公告)日：2017-03-21
申请号：US14773332
申请日：2014-03-12
Applicant: AC IMMUNE S.A. , Genentech, Inc.
Inventor： Gai Ayalon , Danielle Marie Di Cara , Isidro Hotzel , Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson
CPC classification number: C07K16/18 , A61K47/6843 , C07K16/44 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92
Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.
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公开(公告)号：US20150175682A1
公开(公告)日：2015-06-25
申请号：US14390085
申请日：2013-03-15
Applicant: AC Immune S.A. , Katholieke Universiteit Leuven , Genentech, Inc.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven , Gai Ayalon , Danielle Marie Di Cara , Isidro Hotzel
CPC classification number: C07K16/18 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/6896 , G01N2333/4703 , G01N2800/28 , G01N2800/52
Abstract: The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimer's Disease (AD).
Abstract translation: 本发明提供了用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结相关的疾病和病症的终端复合材料的方法。 特别地，本发明涉及人源化抗体，其特异性识别并结合磷酸化病理蛋白质tau构象体，涉及用于治疗和诊断用途的抗体的方法和组合物用于治疗包括阿尔茨海默氏病（AD）在内的tau蛋白病。
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公开(公告)号：US20160304590A1
公开(公告)日：2016-10-20
申请号：US15045804
申请日：2016-02-17
Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN , AC IMMUNE S.A.
Inventor： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren , Oskar Adolfsson
CPC classification number: C07K16/18 , A61K39/0005 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/52
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
Abstract translation: 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物。 特别地，本发明涉及特异性识别和结合磷酸化病理蛋白质tau-构象异构体的抗体以及涉及治疗和诊断用于治疗包括阿尔茨海默病（AD）在内的tau蛋白病的治疗和诊断用途的所述抗体的方法和组合物。
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公开(公告)号：US20140294731A1
公开(公告)日：2014-10-02
申请号：US14348918
申请日：2012-10-05
Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN , AC IMMUNE S.A.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven
IPC: C07K16/18 , G01N33/68 , A61K39/395
CPC classification number: C07K16/18 , A61K39/0005 , A61K39/3955 , A61K2039/505 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821 , G01N2800/52
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles, in particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
Abstract translation: 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物，特别是本发明涉及特异性识别和结合磷酸化病理蛋白质tau的抗体 合并物以及涉及用于治疗和诊断用于治疗包括阿尔茨海默氏病（AD）的tau蛋白病的所述抗体的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US10066010B2
公开(公告)日：2018-09-04
申请号：US15337964
申请日：2016-10-28
Applicant: AC IMMUNE S.A. , KATHOLIEKE UNIVERSITEIT LEUVEN
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
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公开(公告)号：US09657091B2
公开(公告)日：2017-05-23
申请号：US14390085
申请日：2013-03-15
Applicant: AC Immune S.A. , KATHOLIEKE UNIVERSITEIT LEUVEN
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven
CPC classification number: C07K16/18 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/6896 , G01N2333/4703 , G01N2800/28 , G01N2800/52
Abstract: The present invention provides methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
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公开(公告)号：US09540434B2
公开(公告)日：2017-01-10
申请号：US14348918
申请日：2012-10-05
Applicant: AC IMMUNE S.A. , KATHOLIEKE UNIVERSITEIT LEUVEN
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven
CPC classification number: C07K16/18 , A61K39/0005 , A61K39/3955 , A61K2039/505 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821 , G01N2800/52
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles, in particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
Abstract translation: 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物，特别是本发明涉及特异性识别和结合磷酸化病理蛋白质tau的抗体 合并物以及涉及用于治疗和诊断用于治疗包括阿尔茨海默氏病（AD）的tau蛋白病的所述抗体的方法和组合物。
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公开(公告)号：US20170137502A1
公开(公告)日：2017-05-18
申请号：US15337964
申请日：2016-10-28
Applicant: AC IMMUNE S.A. , KATHOLIEKE UNIVERSITEIT LEUVEN
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren , Oskar Adolfsson , Fred Van Leuven
CPC classification number: C07K16/18 , A61K39/0005 , A61K39/3955 , A61K2039/505 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821 , G01N2800/52
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
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公开(公告)号：US10100104B2
公开(公告)日：2018-10-16
申请号：US15045804
申请日：2016-02-17
Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN , AC IMMUNE S.A.
Inventor： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren , Oskar Adolfsson
Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
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