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公开(公告)号：US20140070286A1
公开(公告)日：2014-03-13
申请号：US13852480
申请日：2013-03-28
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Axel SCHERER , Michael D. HENRY , Sameer WALAVALKAR , Thomas A. TOMBRELLO , Andrew P. HOMYK
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.
Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。
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公开(公告)号：US20130230063A1
公开(公告)日：2013-09-05
申请号：US13764620
申请日：2013-02-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Seheon KIM , Axel SCHERER , Aditya RAJAGOPAL , Chieh-Feng CHANG
IPC: H01S3/06
CPC classification number: H01S3/0627 , A61B5/1459 , H01S3/025 , H01S3/091 , H01S3/102 , H01S3/1028 , H01S3/105 , H01S3/115 , H01S5/0607 , H01S5/0612 , H01S5/1042 , H01S5/3013
Abstract: A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. The actuator switch is configured to be activated by a triggering event. Furthermore, the photovoltaic power source is coupled in a series connection with the actuator switch and the control element, the series connection configured to connect the photovoltaic power source to the control element of the microlaser when the actuator switch is activated by the triggering event.
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公开(公告)号：US20240182954A1
公开(公告)日：2024-06-06
申请号：US18352080
申请日：2023-07-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20210169441A1
公开(公告)日：2021-06-10
申请号：US16927911
申请日：2020-07-13
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00 , G01S15/89
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US20150299757A1
公开(公告)日：2015-10-22
申请号：US14753741
申请日：2015-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya RAJAGOPAL , Axel SCHERER , Michael D. HENRY , Sameer WALAVALKAR , Thomas A. TOMBRELLO , Andrew P. HOMYK
IPC: C12Q1/02
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。
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Patent Agency Ranking
公开(公告)号：US20140026413A1
公开(公告)日：2014-01-30
申请号：US14038702
申请日：2013-09-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
IPC: H05K3/10
CPC classification number: H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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公开(公告)号：US20250084463A1
公开(公告)日：2025-03-13
申请号：US18893086
申请日：2024-09-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G06F17/10 , G06F17/11 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/00 , G16B40/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20240093273A1
公开(公告)日：2024-03-21
申请号：US18516842
申请日：2023-11-21
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20180317877A1
公开(公告)日：2018-11-08
申请号：US16038070
申请日：2018-07-17
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US20180049716A1
公开(公告)日：2018-02-22
申请号：US15678789
申请日：2017-08-16
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00
CPC classification number: A61B7/04 , A61B5/0022 , A61B5/02055 , A61B5/021 , A61B5/0816 , A61B5/14532 , A61B5/14542 , A61B5/7253 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/742 , A61B8/4477 , A61B2560/0214
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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