公开(公告)号：US08426361B2

公开(公告)日：2013-04-23

申请号：US12640352

申请日：2009-12-17

Applicant: Odile Esther Levy ,  Carolyn M. Jodka ,  Soumitra S. Ghosh ,  David G. Parkes ,  Richard A. Pittner ,  Lawrence J. D'Souza ,  John S. Ahn ,  Kathryn S. Prickett ,  Jonathan David Roth ,  Sean H. Adams

Inventor： Odile Esther Levy ,  Carolyn M. Jodka ,  Soumitra S. Ghosh ,  David G. Parkes ,  Richard A. Pittner ,  Lawrence J. D'Souza ,  John S. Ahn ,  Kathryn S. Prickett ,  Jonathan David Roth ,  Sean H. Adams

IPC: A61K5/22

CPC classification number: C07K14/575 ,  A61K38/00 ,  C07K14/475

Abstract: The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.

Abstract translation: 本发明提供新型胰腺多肽家族（“PPF”）多肽及其使用方法。

公开(公告)号：US20120253023A1

公开(公告)日：2012-10-04

申请号：US13323608

申请日：2011-12-12

Applicant: Odile Esther LEVY ,  Michael R. Hanley ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christopher J. Soares ,  Soumitra S. Ghosh ,  Lawrence J. D'Souza ,  David G. Parkes ,  Christine M. Mack

Inventor： Odile Esther LEVY ,  Michael R. Hanley ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christopher J. Soares ,  Soumitra S. Ghosh ,  Lawrence J. D'Souza ,  David G. Parkes ,  Christine M. Mack

IPC: C07K19/00

CPC classification number: C07K14/605 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  C07K5/1013 ,  C07K5/1024 ,  C07K14/575 ,  C07K14/58

Abstract: The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

Abstract translation: 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

公开(公告)号：US08263545B2

公开(公告)日：2012-09-11

申请号：US11840921

申请日：2007-08-17

Applicant: Odile Esther Levy ,  Alain D. Baron ,  Lawrence J. D'Souza ,  Mary Erickson ,  Soumitra S. Ghosh ,  Michael R. Hanley ,  Samuel Janssen ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christine M. Mack ,  David G. Parkes ,  Richard A. Pittner ,  Christopher J. Soares ,  Ved Srivastava ,  Andrew A. Young ,  Thao Le

Inventor： Odile Esther Levy ,  Alain D. Baron ,  Lawrence J. D'Souza ,  Mary Erickson ,  Soumitra S. Ghosh ,  Michael R. Hanley ,  Samuel Janssen ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christine M. Mack ,  David G. Parkes ,  Richard A. Pittner ,  Christopher J. Soares ,  Ved Srivastava ,  Andrew A. Young ,  Thao Le

IPC: A61K38/00 ,  A61P3/10

CPC classification number: C07K14/575 ,  A61K38/00 ,  C07K7/06 ,  C07K14/605

Abstract: The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

Abstract translation: 本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或 胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

公开(公告)号：US20100286365A1

公开(公告)日：2010-11-11

申请号：US12680539

申请日：2008-09-26

Applicant: Soumitra S. Ghosh ,  Josue Alfaro-Lopez ,  Lawrence J. D'Souza ,  Odile Esther Levy ,  Qing Lin ,  Christopher J. Soares

Inventor： Soumitra S. Ghosh ,  Josue Alfaro-Lopez ,  Lawrence J. D'Souza ,  Odile Esther Levy ,  Qing Lin ,  Christopher J. Soares

IPC: C07K1/10

CPC classification number: A61K47/64 ,  A61K47/545 ,  A61K47/55

Abstract: Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract translation: 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

公开(公告)号：US20090286723A1

公开(公告)日：2009-11-19

申请号：US12063420

申请日：2006-08-11

Applicant: Odile Esther Levy ,  Michael R. Hanley ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christopher J. Soares ,  Soumitra S. Ghosh ,  Lawrence J. D'Souza ,  David G. Parkes ,  Christine M. Mack ,  Behrouz Bruce Forood

Inventor： Odile Esther Levy ,  Michael R. Hanley ,  Carolyn M. Jodka ,  Diana Y. Lewis ,  Christopher J. Soares ,  Soumitra S. Ghosh ,  Lawrence J. D'Souza ,  David G. Parkes ,  Christine M. Mack ,  Behrouz Bruce Forood

IPC: A61K38/22 ,  C07K2/00 ,  C07K14/585 ,  C07K14/605 ,  C07K14/575 ,  A61P3/10 ,  A61P9/00

CPC classification number: C07K14/575 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

Abstract translation: 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

公开(公告)号：US07001729B2

公开(公告)日：2006-02-21

申请号：US09811131

申请日：2001-03-14

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N29/00 ,  G01N33/573 ,  C12N11/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906175B2

公开(公告)日：2005-06-14

申请号：US09809889

申请日：2001-03-16

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract translation: 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06902908B2

公开(公告)日：2005-06-07

申请号：US09811094

申请日：2001-03-14

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/00 ,  C07H21/04 ,  C12N15/63

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract translation: 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06887670B2

公开(公告)日：2005-05-03

申请号：US09811132

申请日：2001-03-14

Applicant: Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K1/14 ,  C07K1/16 ,  C07K17/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06323039B1

公开(公告)日：2001-11-27

申请号：US09338122

申请日：1999-06-22

Applicant: James A. Dykens ,  Gönül Veliçelebi ,  Soumitra S. Ghosh

Inventor： James A. Dykens ,  Gönül Veliçelebi ,  Soumitra S. Ghosh

IPC: G01N2176

CPC classification number: G01N33/582 ,  G01N33/5005 ,  G01N33/5079 ,  G01N33/542 ,  G01N2500/00

Abstract: The invention provides compositions and methods for monitoring subcellular compartments such as organelles by energy transfer techniques that do not require specific intermolecular affinity binding events between energy transfer donor and energy transfer acceptor molecules. Provided are methods for assaying cellular membrane potential, including mitochondrial membrane potential, by energy transfer methodologies including fluorescence resonance energy transfer (FRET). Diagnostic and drug screening assays are also provided.

Abstract translation: 本发明提供了通过能量转移技术监测亚细胞隔室例如细胞器的组合物和方法，其不需要能量转移供体和能量转移受体分子之间的特异性分子间亲和力结合事件。 提供了通过能量转移方法（包括荧光共振能量转移（FRET））来测定细胞膜电位的方法，包括线粒体膜电位。 还提供诊断和药物筛选测定。