公开(公告)号：US11187006B2

公开(公告)日：2021-11-30

申请号：US16137488

申请日：2018-09-20

Applicant: Alan Qing-Lin Zhu

Inventor： Alan Qing-Lin Zhu

IPC: E04H17/14 ,  E04H17/00 ,  F16B7/04

Abstract: A fence accessory includes at least two ornament bodies, each of the at least two ornament bodies including a first connecting part and a second connecting part at two opposing ends thereof. The first connecting part of one of the at least two ornament bodies and the second connecting part of an other one of the at least two ornament bodies are configured to be connected to a fence bar and clamped together as one unit. Moreover, each of the first connecting part and the second connecting part includes a hook and a slot at two opposing sides of the first connecting part and the second connecting part. The hook of the first connecting part of one ornament body is configured to connect to the slot of the second connecting part of an adjacent accessory body.

公开(公告)号：US09264373B2

公开(公告)日：2016-02-16

申请号：US11994491

申请日：2005-07-01

Applicant: Lei Wan ,  Lars Robert Looström ,  Qing Lin

Inventor： Lei Wan ,  Lars Robert Looström ,  Qing Lin

IPC: H04J3/00 ,  H04L12/805 ,  H04J3/06 ,  H04L12/801 ,  H04L1/00

CPC classification number: H04L47/36 ,  H04J3/0682 ,  H04L1/0007 ,  H04L47/10

Abstract: The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.

Abstract translation: 本发明涉及一种在实现时分双工（TDD）的系统中的第一和第二链路（终端）终端之间的链路上的点对点传输的装置，并且其中信息通过划分为时隙的帧中的链路发送。 其适于使用一个或多个链路参数在每个链路的基础上确定帧的长度，因此帧长度是可变的。

公开(公告)号：US09029332B2

公开(公告)日：2015-05-12

申请号：US13994296

申请日：2011-12-15

Applicant: Qing Lin ,  Avinash Muppidi

Inventor： Qing Lin ,  Avinash Muppidi

IPC: A61K38/12 ,  C07K7/56 ,  C07K1/107 ,  C07K7/08 ,  C07K14/47

CPC classification number: C07K7/56 ,  C07K1/1077 ,  C07K7/08 ,  C07K14/4747 ,  C07K2319/00 ,  C07K2319/95

Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。

公开(公告)号：US20140057857A1

公开(公告)日：2014-02-27

申请号：US13994296

申请日：2011-12-15

Applicant: Qing Lin ,  Avinash Muppidi

Inventor： Qing Lin ,  Avinash Muppidi

IPC: C07K7/56

CPC classification number: C07K7/56 ,  C07K1/1077 ,  C07K7/08 ,  C07K14/4747 ,  C07K2319/00 ,  C07K2319/95

Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。

公开(公告)号：US08551512B2

公开(公告)日：2013-10-08

申请号：US10807546

申请日：2004-03-22

Applicant: Syed Faiyaz Ahmed Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

Inventor： Syed Faiyaz Ahmed Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

IPC: A61F2/82

CPC classification number: B05D5/00 ,  A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/02

Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

公开(公告)号：US20100093086A1

公开(公告)日：2010-04-15

申请号：US12561107

申请日：2009-09-16

Applicant: Qing Lin ,  Mike Madden

Inventor： Qing Lin ,  Mike Madden

IPC: C12N5/02 ,  C07K1/00

CPC classification number: C07K1/045 ,  C07K1/107 ,  C07K1/1136

Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.

Abstract translation: 一种制备缝合肽的方法。 根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。 螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。

公开(公告)号：US20090117108A1

公开(公告)日：2009-05-07

申请号：US10594908

申请日：2005-03-29

Applicant: Xiangbin Wang ,  Hualiang Huang ,  Baofeng Zhao ,  Qi Zhao ,  Jinhua Piao ,  Qing Lin

Inventor： Xiangbin Wang ,  Hualiang Huang ,  Baofeng Zhao ,  Qi Zhao ,  Jinhua Piao ,  Qing Lin

IPC: A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  C12P21/04

CPC classification number: C07K16/00 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/3007 ,  C07K2317/34 ,  C07K2317/626 ,  C07K2317/73

Abstract: The invention is related to a recombinant single-chain tri-specific antibody made from anti-Tumor Associated Antigen (TAA) antibody, FC interlinker, anti-CD3 antibody, HSA interlinker and anti-CD28 antibody in turn. Particularly, the invention relates to an anti-CEA, anti-CD3, anti-CD28 recombinant single-chain tri-specific antibody, CEA-scTsAb, which was constructed with three tandem antibody fragments (anti-CEA scFv, anti-CD3 scFv and anti-CD28 single-domain antibody) linked by two interlinkers (FC interlinker, HSA interlinker), and could be appended by C myc tag or histidine tag ((His)6-tag) at the C terminal. It also concerns a method for construction, expression and purification of the antibody. It also offers the encoded DNA sequence of the antibody, expression vectors and host cells for the vectors.

Abstract translation: 本发明涉及由抗肿瘤相关抗原（TAA）抗体，FC连接子，抗CD3抗体，HSA互连体和抗CD28抗体依次制备的重组单链三特异性抗体。 特别地，本发明涉及用三个串联抗体片段（抗CEA scFv，抗CD3 scFv和构建体）构建的抗CEA，抗CD3，抗CD28重组单链三特异性抗体CEA-scTsAb 抗CD28单结构域抗体）通过两个连接子（FC连接子，HSA连接子）连接，并可以通过C末端标签或组氨酸标签（（His）6-标签）附加。 它还涉及抗体的构建，表达和纯化的方法。 它还提供抗体的编码DNA序列，载体的表达载体和宿主细胞。

公开(公告)号：US20090046606A1

公开(公告)日：2009-02-19

申请号：US11994491

申请日：2005-07-01

Applicant: Lei Wan ,  Lars Robert Loostrom ,  Qing Lin

Inventor： Lei Wan ,  Lars Robert Loostrom ,  Qing Lin

IPC: H04J3/00

CPC classification number: H04L47/36 ,  H04J3/0682 ,  H04L1/0007 ,  H04L47/10

Abstract: The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.

Abstract translation: 本发明涉及一种在实现时分双工（TDD）的系统中的第一和第二链路（终端）终端之间的链路上的点对点传输的装置，并且其中信息通过划分为时隙的帧中的链路发送。 其适于使用一个或多个链路参数在每个链路的基础上确定帧的长度，因此帧长度是可变的。

公开(公告)号：US20080241223A1

公开(公告)日：2008-10-02

申请号：US12113434

申请日：2008-05-01

Applicant: Thierry NIVAGGIOLI ,  Jane Guo Shiah ,  Qing Lin

Inventor： Thierry NIVAGGIOLI ,  Jane Guo Shiah ,  Qing Lin

IPC: A61F2/00 ,  A61K31/56 ,  A61P27/02

CPC classification number: A61K9/0051 ,  A61K9/204 ,  A61K31/57 ,  A61K31/573 ,  A61K47/34

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract translation: 尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。 植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。

公开(公告)号：US07347412B1

公开(公告)日：2008-03-25

申请号：US11223384

申请日：2005-09-09

Applicant: Alan Qing-Lin Zhu

Inventor： Alan Qing-Lin Zhu

IPC: E04H17/14

CPC classification number: E04H17/1439 ,  E04H17/1443 ,  F16B2200/20 ,  F16B2200/40 ,  Y10T403/606

Abstract: A modular picket fence including a pair of vertical posts positioned at suitable distance and adapted to be secured to a suitable support surface. A pair of horizontal upper and lower rails extend between and secured to the vertical posts. The upper rail has a plurality of apertures which are aligned with a plurality of apertures on the lower rail. The apertures can be of any given shape including square, narrow rectangular, wide rectangular, oval, round, narrow polygonal and wide polygonal. A plurality of vertical pickets having a cross-sectional shape corresponding to the shape of the apertures in the horizontal rails are respectively inserted through into aligned apertures of the upper and lower rails. The end portion of each vertical picket has two transverse apertures.

Abstract translation: 一个模块化的篱笆围栏，包括一对垂直柱，该立柱位于适当的距离处并适于固定在合适的支撑表面上。 一对水平的上，下导轨在垂直柱之间延伸并固定到立柱上。 上轨道具有与下轨道上的多个孔对准的多个孔。 孔可以是任何给定的形状，包括方形，窄矩形，宽矩形，椭圆形，圆形，窄多边形和宽多边形。 具有对应于水平轨道中的孔的形状的横截面形状的多个垂直桩分别插入到上轨道和下轨道的对准的孔中。 每个垂直焊接头的端部具有两个横向孔。