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公开(公告)号：US20170137370A1
公开(公告)日：2017-05-18
申请号：US15421569
申请日：2017-02-01
申请人： GRÜNENTHAL GMBH
IPC分类号： C07C215/54 , C07C217/74
CPC分类号： C07C215/54 , A61K9/0056 , A61K9/0058 , A61K9/0095 , C07B2200/07 , C07C215/62 , C07C215/64 , C07C217/68 , C07C217/74 , C07C2601/14 , C07D275/06 , C07D291/06 , C07D489/04
摘要： The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance and of at least one sugar substitute, to medicaments containing these salts, and to the use of these salts for producing medicaments.
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公开(公告)号：US09580386B2
公开(公告)日：2017-02-28
申请号：US14459540
申请日：2014-08-14
申请人： GRÜNENTHAL GMBH
发明人： Bert Nolte , Wolfgang Schröder , Klaus Linz , Werner Englberger , Hans Schick , Heinz Graubaum , Birgit Braun , Sigrid Ozegowski , József Bálint , Helmut Sonnenschein
IPC分类号： C07C211/00 , C07D209/20 , C07C211/40 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C275/24 , C07C311/07 , C07C311/18 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08 , A61K31/135 , A61K45/06 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , C07C211/54 , C07C237/24 , C07C311/37 , C07D251/48
CPC分类号： C07D209/20 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , A61K45/06 , C07C211/40 , C07C211/54 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C237/24 , C07C275/24 , C07C311/07 , C07C311/18 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/48 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译： 本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。
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23.发明授权Fluoromethyl-substituted pyrrole carboxamides as CaV2.2 calcium channel blockers 有权氟甲基取代的吡咯甲酰胺作为CaV2.2钙通道阻断剂公开(公告)号：US09562036B2
公开(公告)日：2017-02-07
申请号：US15185124
申请日：2016-06-17
申请人： GRÜNENTHAL GMBH
发明人： Melanie Reich , Stefan Schunk , Florian Jakob , Henning Steinhagen , Nils Damann , Michael Haurand , Marc Rogers , Kathy MacKenzie
IPC分类号： C07D403/04 , C07D401/04 , C07D409/04 , C07D413/04 , C07D403/14 , C07D413/14
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及带有氟甲基部分作为电压门控钙通道阻断剂的吡咯甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或障碍的这些化合物。
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公开(公告)号：US20170000739A1
公开(公告)日：2017-01-05
申请号：US15265263
申请日：2016-09-14
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/485 , A61K31/135
CPC分类号： A61K31/135 , A61K9/0053 , A61K9/20 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K47/10
摘要： The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
摘要翻译： 本发明涉及一种防滥用热成型剂型，除了一种或多种具有滥用潜力的活性成分以外，还含有生理上可接受的辅助物质，至少一种具有至少500N的断裂强度的合成或天然聚合物 以及其生产方法。
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公开(公告)号：US20160374965A1
公开(公告)日：2016-12-29
申请号：US15257972
申请日：2016-09-07
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/137 , A61K9/00 , A61K9/48
CPC分类号： A61K31/137 , A61K9/0053 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： The invention is directed to an immediate release capsule which mitigates the abuse of Tapentadol or physiologically acceptable salt thereof by direct intravenous injection. The capsule comprises a tamper resistant formulation which when mixed with water and heated, results in a turbid, bubbling mixture that is not injectable with a standard insulin syringe.
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公开(公告)号：US09527832B2
公开(公告)日：2016-12-27
申请号：US14883986
申请日：2015-10-15
申请人： GRÜNENTHAL GMBH
发明人： Ingo Konetzki , Florian Jakob , Tobias Craan , Christian Hesslinger , Paul Ratcliffe , Antonio Nardi
IPC分类号： C07D413/04 , C07D403/04 , C07D495/04
CPC分类号： C07D403/04 , C07D413/04 , C07D495/04
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
摘要翻译： 本发明涉及通式（I）的新型取代的稠合嘧啶化合物，其中化学基团，取代基和指数如说明书中所定义，以及它们作为药物的用途，特别是作为用于治疗病症和疾病的药物 可以通过PDE4酶的抑制来治疗。
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公开(公告)号：US20160367549A1
公开(公告)日：2016-12-22
申请号：US15255534
申请日：2016-09-02
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/485 , A61K9/20 , A61K9/28 , A61K9/00
CPC分类号： A61K9/2031 , A61K9/0002 , A61K9/0053 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/28 , A61K9/2893 , A61K31/485
摘要： The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
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28.发明授权公开(公告)号：US09505724B2
公开(公告)日：2016-11-29
申请号：US14817683
申请日：2015-08-04
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/517 , C07D239/70 , C07C53/18 , C07D405/04 , C07D239/94
CPC分类号： C07D239/70 , A61K31/517 , C07C53/18 , C07D239/94 , C07D405/04
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
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29.发明申请TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A MATRIX 审中-公开抗菌固定剂量组合，从颗粒和基质提供两种药物的快速释放公开(公告)号：US20160310486A1
公开(公告)日：2016-10-27
申请号：US15135588
申请日：2016-04-22
申请人： GRÜNENTHAL GMBH
发明人： Klaus WENING , Lutz BARNSCHEID , Anja GEIßLER , Jana DENKER , Jessica REDMER
IPC分类号： A61K31/485 , A61K9/20 , A61K31/167 , A61K9/16 , A61K9/48 , A61K45/06
CPC分类号： A61K31/485 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/2031 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/407 , A61K45/06 , A61K2300/00
摘要： A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
摘要翻译： 包含两种药理学活性成分的抗篡改药物剂型，其中所述剂型在体外条件下提供快速释放，优选根据Ph.Eur。立即释放两种药理活性成分。 剂型可用于药物联合治疗，其通过施用含有多于一种药理学活性成分的剂型作为固定剂量组合来实现。
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30.发明申请TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER 审中-公开抗菌固定剂量组合提供从颗粒和粉末中快速释放两种药物公开(公告)号：US20160310427A1
公开(公告)日：2016-10-27
申请号：US15135594
申请日：2016-04-22
申请人： GRÜNENTHAL GMBH
发明人： KLAUS WENING , LUTZ BARNSCHEID , ANJA GEISSLER , JANA DENKER , JESSICA REDMER
IPC分类号： A61K9/16 , A61K31/137 , A61K9/48 , A61K31/485 , A61K31/167
CPC分类号： A61K9/1641 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/4808 , A61K9/4825 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/407 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
摘要翻译： 包含两种药理学活性成分的抗篡改药物剂型，其中所述剂型在体外条件下提供快速释放，优选根据Ph.Eur。立即释放两种药理活性成分。 剂型可用于药物联合治疗，其通过施用含有多于一种药理学活性成分的剂型作为固定剂量组合来实现。
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