- 专利标题: ABUSE-PROOFED ORAL DOSAGE FORM
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申请号: US15255534申请日: 2016-09-02
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公开(公告)号: US20160367549A1公开(公告)日: 2016-12-22
- 发明人: JOHANNES BARTHOLOMÄUS , Heinrich KUGELMANN , Elisabeth ARKENAU-MARIC
- 申请人: GRÜNENTHAL GMBH
- 申请人地址: DE Aachen
- 专利权人: GRÜNENTHAL GMBH
- 当前专利权人: GRÜNENTHAL GMBH
- 当前专利权人地址: DE Aachen
- 优先权: DE102004032049.7 20040701
- 主分类号: A61K31/485
- IPC分类号: A61K31/485 ; A61K9/20 ; A61K9/28 ; A61K9/00
摘要:
The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
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