公开(公告)号：US20170312271A1

公开(公告)日：2017-11-02

申请号：US15649880

申请日：2017-07-14

Applicant: Grünenthal GmbH

Inventor： Judy ASHWORTH ,  Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN

IPC: A61K31/485 ,  A61J3/10 ,  A61K9/20 ,  B29C43/02 ,  B29B9/12 ,  B29B9/02 ,  B29B7/00 ,  A61K31/554 ,  A61K31/55 ,  A61J3/00 ,  A61K31/4418 ,  A61K31/277 ,  A61K31/135 ,  A61K9/48 ,  A61K9/28 ,  A61K31/4422 ,  B29C35/02 ,  B29C45/00 ,  B29K105/00 ,  B29L31/00

Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.

公开(公告)号：US20200215053A1

公开(公告)日：2020-07-09

申请号：US16797055

申请日：2020-02-21

Applicant: GRÜNENTHAL GMBH

Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMAEUS ,  Heinrich KUGELMANN

IPC: A61K31/485 ,  B29C48/00 ,  B29C48/21 ,  B29C48/14 ,  A61K9/20 ,  A61K31/135 ,  A61K31/277 ,  A61K31/4418 ,  A61K31/55 ,  A61K31/554 ,  A61J3/00 ,  A61K9/48 ,  A61J3/10 ,  A61K9/28 ,  A61K31/4422 ,  B29B7/00 ,  B29B9/02 ,  B29B9/12 ,  B29C43/02 ,  A61J3/06

Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

公开(公告)号：US20170209379A1

公开(公告)日：2017-07-27

申请号：US15459180

申请日：2017-03-15

Applicant: GRÜNENTHAL GMBH

Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMAEUS ,  Heinrich KUGELMANN

IPC: A61K9/20 ,  A61K31/485 ,  B29C47/06 ,  B29C47/00 ,  A61J3/10 ,  A61K31/135 ,  A61J3/06

CPC classification number: A61K31/485 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/2095 ,  A61K9/2893 ,  A61K9/4808 ,  A61K31/135 ,  A61K31/277 ,  A61K31/4418 ,  A61K31/4422 ,  A61K31/55 ,  A61K31/554 ,  B29B7/002 ,  B29B9/02 ,  B29B9/12 ,  B29C35/0261 ,  B29C43/02 ,  B29C45/0001 ,  B29C47/0004 ,  B29C47/004 ,  B29C47/0066 ,  B29C47/0085 ,  B29C47/065 ,  B29C2793/009 ,  B29K2105/0035 ,  B29K2105/0044 ,  B29K2105/251 ,  B29K2995/0056 ,  B29L2031/753 ,  B29L2031/772

Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

公开(公告)号：US20170000739A1

公开(公告)日：2017-01-05

申请号：US15265263

申请日：2016-09-14

Applicant: GRÜNENTHAL GMBH

Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

IPC: A61K9/20 ,  A61K31/485 ,  A61K31/135

CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2095 ,  A61K31/485 ,  A61K31/515 ,  A61K31/5513 ,  A61K47/10

Abstract: The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.

Abstract translation: 本发明涉及一种防滥用热成型剂型，除了一种或多种具有滥用潜力的活性成分以外，还含有生理上可接受的辅助物质，至少一种具有至少500N的断裂强度的合成或天然聚合物 以及其生产方法。

公开(公告)号：US20160367549A1

公开(公告)日：2016-12-22

申请号：US15255534

申请日：2016-09-02

Applicant: GRÜNENTHAL GMBH

Inventor： JOHANNES BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

IPC: A61K31/485 ,  A61K9/20 ,  A61K9/28 ,  A61K9/00

CPC classification number: A61K9/2031 ,  A61K9/0002 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2095 ,  A61K9/28 ,  A61K9/2893 ,  A61K31/485

Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

公开(公告)号：US20160184295A1

公开(公告)日：2016-06-30

申请号：US15059730

申请日：2016-03-03

Applicant: GRÜNENTHAL GMBH

Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

IPC: A61K31/485 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28

CPC classification number: A61K9/2031 ,  A61K9/0002 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2095 ,  A61K9/28 ,  A61K9/2893 ,  A61K31/485

Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

公开(公告)号：US20150313845A1

公开(公告)日：2015-11-05

申请号：US14795900

申请日：2015-07-10

Applicant: GRÜNENTHAL GMBH

Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/485

CPC classification number: A61K9/2031 ,  A61K9/0002 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2095 ,  A61K9/28 ,  A61K9/2893 ,  A61K31/485

Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

Abstract translation: 本发明涉及一种每日给药一次具有受控阿片样物质释放的滥用防制口服剂型，其特征在于其包含至少一种具有滥用潜力（A）的阿片样物质，至少一种合成或天然聚合物（C） ，任选的延迟释放基质辅助物质，生理上可接受的辅助物质（B），任选的蜡（D）和任选的至少一种延迟释放涂层，组分（C）或（D） 至少500N，优选至少1000N。

公开(公告)号：US20200038330A1

公开(公告)日：2020-02-06

申请号：US16542808

申请日：2019-08-16

Applicant: GRÜNENTHAL GMBH

Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/485 ,  A61K9/28

Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

公开(公告)号：US20190321358A1

公开(公告)日：2019-10-24

申请号：US16455813

申请日：2019-06-28

Applicant: GRÜNENTHAL GMBH

Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMAEUS ,  Heinrich KUGELMANN

IPC: A61K31/485 ,  B29C48/00 ,  A61K9/20 ,  B29C48/21 ,  B29C48/14 ,  A61K31/55 ,  B29C43/02 ,  A61K9/48 ,  A61J3/00 ,  A61K31/135 ,  A61K31/554 ,  A61K31/4418 ,  B29B7/00 ,  A61K31/277 ,  B29B9/02 ,  A61J3/06 ,  A61K31/4422 ,  A61J3/10 ,  B29B9/12 ,  A61K9/28

Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

公开(公告)号：US20160367501A1

公开(公告)日：2016-12-22

申请号：US15249574

申请日：2016-08-29

Applicant: GRÜNENTHAL GMBH

Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN

IPC: A61K31/135 ,  A61K47/10 ,  A61K9/20 ,  A61K9/00

CPC classification number: A61K31/135 ,  A61J3/06 ,  A61J3/10 ,  A61J2200/20 ,  A61K9/0053 ,  A61K9/2031 ,  A61K9/2077 ,  A61K9/2095 ,  A61K31/485 ,  A61K47/10 ,  A61K47/34 ,  B29C43/003 ,  B29C43/006 ,  B29L2031/00

Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ≧500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.