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公开(公告)号：US20160166517A1
公开(公告)日：2016-06-16
申请号：US15054201
申请日：2016-02-26
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/135 , A61K9/20
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
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公开(公告)号：US20150091201A1
公开(公告)日：2015-04-02
申请号：US14564188
申请日：2014-12-09
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61K9/1694 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/05 , A61K31/135 , A61K31/485
摘要： The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
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公开(公告)号：US20170137370A1
公开(公告)日：2017-05-18
申请号：US15421569
申请日：2017-02-01
申请人： GRÜNENTHAL GMBH
IPC分类号： C07C215/54 , C07C217/74
CPC分类号： C07C215/54 , A61K9/0056 , A61K9/0058 , A61K9/0095 , C07B2200/07 , C07C215/62 , C07C215/64 , C07C217/68 , C07C217/74 , C07C2601/14 , C07D275/06 , C07D291/06 , C07D489/04
摘要： The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance and of at least one sugar substitute, to medicaments containing these salts, and to the use of these salts for producing medicaments.
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公开(公告)号：US20160367549A1
公开(公告)日：2016-12-22
申请号：US15255534
申请日：2016-09-02
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/485 , A61K9/20 , A61K9/28 , A61K9/00
CPC分类号： A61K9/2031 , A61K9/0002 , A61K9/0053 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/28 , A61K9/2893 , A61K31/485
摘要： The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
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公开(公告)号：US20170209378A9
公开(公告)日：2017-07-27
申请号：US15057161
申请日：2016-03-01
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/485
CPC分类号： A61K9/2031 , A61K9/0002 , A61K9/0053 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/28 , A61K9/2893 , A61K31/485
摘要： The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
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公开(公告)号：US20160199305A1
公开(公告)日：2016-07-14
申请号：US14965935
申请日：2015-12-11
申请人： GRÜNENTHAL GMBH
发明人： EUGEEN MARIE JOZEF JANS , FILIP RENÉ IRENA KIEKENS , JODY FIRMIN MARCELINE VOORSPOELS , ANNE FAURE , IRIS ZIEGLER , ELISABETH ARKENAU-MARIC , LUTZ BARNSCHEID , JOHANNES BARTHOLOMÄUS , MARC FREVEL , ERIC GALIA , ANDREA SCHÜESSELE
IPC分类号： A61K9/20 , A61K31/135
CPC分类号： A61K9/2072 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K31/135 , A61K31/137 , Y10T428/24479
摘要： The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
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公开(公告)号：US20160374963A1
公开(公告)日：2016-12-29
申请号：US15257255
申请日：2016-09-06
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/135 , B29C47/40 , B29C47/00 , A61K9/20 , B29C47/06
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
摘要翻译： 本发明涉及热成型而不被挤出并且防止滥用的剂量，除了一种或多种可能遭受滥用的活性物质之外，还包含至少一种具有至少500N的断裂强度的合成或天然聚合物 和任选的生理上可接受的佐剂。 本发明还涉及用于生产所述剂型的相应方法。
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公开(公告)号：US20160367487A1
公开(公告)日：2016-12-22
申请号：US15257079
申请日：2016-09-06
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , B30B11/16 , A61K31/135
CPC分类号： A61K9/2095 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K31/135 , A61K31/485 , A61K31/515 , A61K31/5513 , B30B11/16 , B30B11/34
摘要： The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.
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公开(公告)号：US20150359747A1
公开(公告)日：2015-12-17
申请号：US14834532
申请日：2015-08-25
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/135
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
摘要翻译： 本发明涉及一种剂型，其不经挤出而被热成型并且被防止滥用，其包含至少一种具有至少500N的断裂强度的合成或天然聚合物，除了一种或多种可能经受 滥用和任选的生理上可接受的佐剂。 本发明还涉及用于生产所述剂型的相应方法。
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公开(公告)号：US20140322323A1
公开(公告)日：2014-10-30
申请号：US14261625
申请日：2014-04-25
申请人： GRÜNENTHAL GMBH
发明人： EUGEEN MARIE JOZEF JANS , FILIP RENÉ IRENA KIEKENS , JODY FIRMIN MARCELINE VOORSPOELS , ANNE FAURE , IRIS ZIEGLER , ELISABETH ARKENAU-MARIC , LUTZ BARNSCHEID , JOHANNES BARTHOLOMÄUS , MARC FREVEL , ERIC GALIA , ANDREA SCHÜESSELE
IPC分类号： A61K9/20 , A61K31/137
CPC分类号： A61K9/2072 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K31/135 , A61K31/137 , Y10T428/24479
摘要： The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
摘要翻译： 本发明涉及药物剂型，优选具有其中所含的药理活性化合物（A）的受控释放，所述药物剂型非常优选是防篡改的，最优选地具有至少500N的断裂强度B1，方向为 并且在延伸方向E2具有小于500N的断裂强度B2。
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