公开(公告)号：US20160199305A1

公开(公告)日：2016-07-14

申请号：US14965935

申请日：2015-12-11

申请人： GRÜNENTHAL GMBH

发明人： EUGEEN MARIE JOZEF JANS ,  FILIP RENÉ IRENA KIEKENS ,  JODY FIRMIN MARCELINE VOORSPOELS ,  ANNE FAURE ,  IRIS ZIEGLER ,  ELISABETH ARKENAU-MARIC ,  LUTZ BARNSCHEID ,  JOHANNES BARTHOLOMÄUS ,  MARC FREVEL ,  ERIC GALIA ,  ANDREA SCHÜESSELE

IPC分类号： A61K9/20 ,  A61K31/135

CPC分类号： A61K9/2072 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/135 ,  A61K31/137 ,  Y10T428/24479

摘要： The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.

公开(公告)号：US20140322323A1

公开(公告)日：2014-10-30

申请号：US14261625

申请日：2014-04-25

申请人： GRÜNENTHAL GMBH

发明人： EUGEEN MARIE JOZEF JANS ,  FILIP RENÉ IRENA KIEKENS ,  JODY FIRMIN MARCELINE VOORSPOELS ,  ANNE FAURE ,  IRIS ZIEGLER ,  ELISABETH ARKENAU-MARIC ,  LUTZ BARNSCHEID ,  JOHANNES BARTHOLOMÄUS ,  MARC FREVEL ,  ERIC GALIA ,  ANDREA SCHÜESSELE

IPC分类号： A61K9/20 ,  A61K31/137

CPC分类号： A61K9/2072 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/135 ,  A61K31/137 ,  Y10T428/24479

摘要： The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.

摘要翻译： 本发明涉及药物剂型，优选具有其中所含的药理活性化合物（A）的受控释放，所述药物剂型非常优选是防篡改的，最优选地具有至少500N的断裂强度B1，方向为 并且在延伸方向E2具有小于500N的断裂强度B2。