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    INDOLE COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC RECEPTOR
    2.
    发明申请
    INDOLE COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC RECEPTOR 失效
    作为MUSCARINIC受体的阳性调节因子的化合物

    公开(公告)号：US20130210773A1

    公开(公告)日：2013-08-15

    申请号：US13702800

    申请日：2011-06-21

    申请人： Craig W. Lindsley

    发明人： Craig W. Lindsley

    IPC分类号： C07D413/14 ,  C07D405/12 ,  C07D401/14 ,  C07D413/12 ,  C07D401/12

    CPC分类号： C07D413/14 ,  C07D209/30 ,  C07D213/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

    摘要： In one aspect, the invention relates to indole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    摘要翻译： 一方面，本发明涉及可用作毒蕈碱性乙酰胆碱受体M1（mAChR M1）的正变构调节剂的吲哚化合物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与毒蕈碱性乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    Process for the production of pyridine or alkyl substituted pyridines
    9.
    发明授权
    Process for the production of pyridine or alkyl substituted pyridines 失效
    制备吡啶或烷基取代吡啶的方法

    公开(公告)号：US4675410A

    公开(公告)日：1987-06-23

    申请号：US848891

    申请日：1986-03-21

    申请人： David Feitler ,  Wolfgang Schimming ,  Henry Wetstein

    发明人： David Feitler ,  Wolfgang Schimming ,  Henry Wetstein

    IPC分类号： C07D213/08 ,  C07D213/09 ,  C07D213/10 ,  C07D213/12

    CPC分类号： C07D213/08 ,  C07D213/10 ,  C07D213/12

    摘要： A process for preparing pyridine or alkyl substituted pyridines in high yield, comprises reacting a C.sub.2-5 -aldehyde, a C.sub.3-5 -ketone or a mixture thereof, ammonia and, optionally, formaldehyde, in the gas phase in contact with a fluidized or otherwise movable bed of a catalytically effective amount of a crystalline aluminosilicate zeolite catalyst in the acidic form and having a constraint index of about 1 to about 12, with an actual contact time of the reactants with the catalyst which is at least as great as said actual contact time when the reaction is conducted in a 1 inch diameter fluid bed reactor with a pseudo contact time of at least about 2.5 seconds.

    摘要翻译： 以高产率制备吡啶或烷基取代的吡啶的方法包括使C2-5-醛，C3-5-酮或其混合物与氨和任选的甲醛在气相中与流化或 催化有效量的具有酸性形式的结晶硅铝酸盐沸石催化剂的活性床，其约束指数为约1至约12，反应物与催化剂的实际接触时间至少等于所述实际值 当反应在具有至少约2.5秒的伪接触时间的1英寸直径流化床反应器中进行时的接触时间。

    Synthesis of pyridine and alkylpyridines
    10.
    发明授权
    Synthesis of pyridine and alkylpyridines 失效
    吡啶和烷基吡啶的合成

    公开(公告)号：US4220783A

    公开(公告)日：1980-09-02

    申请号：US037265

    申请日：1979-05-09

    申请人： Clarence D. Chang ,  William H. Lang

    发明人： Clarence D. Chang ,  William H. Lang

    IPC分类号： C07D213/10 ,  C07D213/12 ,  C07D213/08

    CPC分类号： C07D213/12 ,  C07D213/10

    摘要： A method is provided for synthesizing pyridine or alkylpyridines by reacting ammonia and a carbonyl reactant which is an aldehyde containing 2 to 4 carbon atoms, a ketone containing 3 to 5 carbon atoms or mixtures of said aldehydes and/or ketones under effective conditions in the presence of a catalyst comprising a crystalline aluminosilicate zeolite having a silica to alumina ratio of at least about 12 and a constraint index within the approximate range of 1 to 12 and recovering from the resulting reaction mixture, a product containing at least one compound of pyridine or an alkylpyridine. Addition of methanol and/or formaldehyde to the feed improves selectivity to unsubstituted pyridine.

    摘要翻译： 提供了一种通过使氨和羰基反应物（含有2至4个碳原子的羰基反应物），含3至5个碳原子的酮或所述醛和/或酮的混合物在有效条件下在存在下反应来合成吡啶或烷基吡啶的方法 的催化剂，其包含具有至少约12的二氧化硅与氧化铝的结晶硅铝酸盐沸石和约1至12的约束指数，并从所得反应混合物中回收含有至少一种吡啶化合物或 烷基吡啶。 向进料中加入甲醇和/或甲醛提高了对未取代吡啶的选择性。