公开(公告)号：US20050145253A1

公开(公告)日：2005-07-07

申请号：US11071850

申请日：2005-03-02

Applicant: Peter Wilson ,  Antony Fields ,  Hanson Gifford ,  John McCutcheon ,  Michael Hendricksen ,  Alan Rapacki ,  David Tholfsen ,  Michael Barrett ,  Ronald Hundertmark ,  Douglas Sutton

Inventor： Peter Wilson ,  Antony Fields ,  Hanson Gifford ,  John McCutcheon ,  Michael Hendricksen ,  Alan Rapacki ,  David Tholfsen ,  Michael Barrett ,  Ronald Hundertmark ,  Douglas Sutton

IPC: A61B17/00 ,  A61B17/24 ,  A61F2/04 ,  A61F2/06 ,  A61F2/24 ,  A61M16/00 ,  A61M16/20 ,  A61M11/00 ,  A62B9/06

CPC classification number: A61F2/2412 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2/06 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/91 ,  A61F2002/043 ,  A61F2002/9522 ,  Y10S128/912

Abstract: Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway. A region of the lung is aspirated distal of the flow control device while the patient is inhaling.

Abstract translation: 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动。 当患者正在吸入时，肺部的区域被吸入流量控制装置的远端。

公开(公告)号：US06901927B2

公开(公告)日：2005-06-07

申请号：US10303240

申请日：2002-11-22

Applicant: Mark E. Deem ,  Hanson S. Gifford, III ,  Ronald French ,  Douglas Sutton

Inventor： Mark E. Deem ,  Hanson S. Gifford, III ,  Ronald French ,  Douglas Sutton

IPC: A61B17/22 ,  A61B19/00 ,  A61F2/04 ,  A61F2/24 ,  A61M23/00 ,  A61M15/00 ,  A61M16/00 ,  A62B7/00 ,  A62B18/00

CPC classification number: A61F2/24 ,  A61B17/12104 ,  A61B17/12172 ,  A61B17/221 ,  A61B2017/1205 ,  A61B2017/2215 ,  A61B2090/061 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/91 ,  A61F2002/043 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0091 ,  F16K15/147

Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.

公开(公告)号：US20050080438A1

公开(公告)日：2005-04-14

申请号：US10686326

申请日：2003-10-14

Applicant: Gary Weller ,  Jamy Gannoe ,  Craig Gerbi ,  Douglas Sutton ,  Andrew Hancock ,  Gilbert Mata

Inventor： Gary Weller ,  Jamy Gannoe ,  Craig Gerbi ,  Douglas Sutton ,  Andrew Hancock ,  Gilbert Mata

IPC: A61B20060101 ,  A61B17/072 ,  A61B17/08 ,  A61B17/11 ,  A61B17/28 ,  A61B17/32

CPC classification number: A61B17/29 ,  A61B17/07207 ,  A61B17/1114 ,  A61B2017/00323 ,  A61B2017/00353 ,  A61B2017/00946 ,  A61B2017/07214 ,  A61B2017/1103 ,  A61B2017/2905 ,  A61B2017/306

Abstract: A system for tissue approximation and fixation is described herein. The devices are advanced in a minimally invasive manner within a patient's body to create one or several divisions or plications within a hollow body organ. The system comprises a tissue acquisition and folding device and a tissue stapling or fixation device, each of which is used together as a system. The acquisition device is used to approximate tissue regions from within the hollow body organ and the stapling device is advanced through a main lumen defined through the acquisition device and is used to affix the approximated tissue. The stapling device is keyed to maintain its rotational orientation relative to the acquisition device as well as to provide the user positional information of the stapling device. The acquisition device is also configured to provide lateral stability to the stapling device prior to the stapling device being clamped onto tissue.

Abstract translation: 本文描述了用于组织近似和固定的系统。 这些装置在患者体内以微创方式前进，以在中空身体器官内产生一个或多个分裂或症状。 该系统包括组织采集和折叠装置和组织缝合或固定装置，每个组合装订或固定装置一起用作系统。 采集装置用于从中空体器官内部近似组织区域，并且缝合装置前进穿过通过采集装置限定的主腔，并用于固定近似组织。 锁定装置被锁定以相对于采集装置保持其旋转定向，并且提供用户装订装置的位置信息。 采集装置还被配置为在缝合装置被夹持到组织之前为吻合装置提供侧向稳定性。

公开(公告)号：US20050051163A1

公开(公告)日：2005-03-10

申请号：US10703919

申请日：2003-11-06

Applicant: Mark Deem ,  Bernard Andreas ,  Sunmi Chew ,  Antony Fields ,  Ronald French ,  Hanson Gifford ,  Ronald Hundermark ,  Alan Rapacki ,  Douglas Sutton ,  Peter Wilson

Inventor： Mark Deem ,  Bernard Andreas ,  Sunmi Chew ,  Antony Fields ,  Ronald French ,  Hanson Gifford ,  Ronald Hundermark ,  Alan Rapacki ,  Douglas Sutton ,  Peter Wilson

IPC: A61B17/22 ,  A61B19/00 ,  A61F2/04 ,  A61F2/24 ,  A61M23/00 ,  A62B7/00 ,  A61M15/00

CPC classification number: A61F2/24 ,  A61B17/12104 ,  A61B17/12172 ,  A61B17/221 ,  A61B2017/1205 ,  A61B2017/2215 ,  A61B2090/061 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/91 ,  A61F2002/043 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0091 ,  F16K15/147

Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.

公开(公告)号：US06214405B1

公开(公告)日：2001-04-10

申请号：US08733417

申请日：1996-10-18

Applicant: Michael Eugene Horn ,  Eric Jon Eikenberry ,  Juan Enrique Romero Lanuza ,  James Douglas Sutton

Inventor： Michael Eugene Horn ,  Eric Jon Eikenberry ,  Juan Enrique Romero Lanuza ,  James Douglas Sutton

IPC: A23D900

CPC classification number: A23D9/00

Abstract: Peanuts and peanut oil having improved stability and resistance to oxidative degradation as a result of improved fatty acid profile. Edible compositions containing such peanuts and oil, and a method of improving the oxidative stability of peanut-oil containing compositions by adding such oil to them.

Abstract translation: 花生和花生油具有改进的稳定性和抗氧化降解的抵抗力，这是由于改善的脂肪酸分布。 含有这种花生和油的食用组合物，以及通过向其中加入这种油来提高含花生油的组合物的氧化稳定性的方法。

公开(公告)号：US5684232A

公开(公告)日：1997-11-04

申请号：US709231

申请日：1996-09-03

Applicant: Michael Eugene Horn ,  Eric Jon Eikenberry ,  Juan Enrique Romero Lanuza ,  James Douglas Sutton

Inventor： Michael Eugene Horn ,  Eric Jon Eikenberry ,  Juan Enrique Romero Lanuza ,  James Douglas Sutton

IPC: A01H1/06 ,  A01H5/10 ,  A01H5/00 ,  A01H1/04

CPC classification number: A01H1/06 ,  A01H5/10

Abstract: A commercially viable, runner-type peanut cultivar, as well as seeds and plants of the cultivar, agronomically similar to Florunner but having an improved fatty acid profile in the seed oil.

Abstract translation: 一种商业上可行的转轮型花生品种，以及栽培品种的种子和植物，在农艺学上类似于Florunner，但在种子油中具有改善的脂肪酸分布。

公开(公告)号：US09107773B2

公开(公告)日：2015-08-18

申请号：US13555056

申请日：2012-07-20

Applicant: Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

Inventor： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC: A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC classification number: G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

Abstract: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US09072527B2

公开(公告)日：2015-07-07

申请号：US13942223

申请日：2013-07-15

Applicant: Mark Deem ,  Denise Zarins ,  Douglas Sutton ,  Hanson Gifford, III ,  Howard R. Levin ,  Mark Gelfand ,  Benjamin J. Clark

Inventor： Mark Deem ,  Denise Zarins ,  Douglas Sutton ,  Hanson Gifford, III ,  Howard R. Levin ,  Mark Gelfand ,  Benjamin J. Clark

IPC: A61B18/14 ,  A61N1/32 ,  A61N1/36 ,  A61N5/00 ,  A61N1/05 ,  A61B18/00

CPC classification number: A61N1/36117 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00702 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00982 ,  A61B2018/1435 ,  A61N1/0551 ,  A61N1/32 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36128 ,  A61N5/00

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.

Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置为用于实现这种神经调节的脉冲电场的血管外递送。

公开(公告)号：US08934978B2

公开(公告)日：2015-01-13

申请号：US14258802

申请日：2014-04-22

Applicant: Mark E. Deem ,  Hanson Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

Inventor： Mark E. Deem ,  Hanson Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61B18/12 ,  A61B18/14 ,  A61M5/14 ,  A61N1/04 ,  A61N1/05 ,  A61N1/32 ,  A61N1/36 ,  A61B18/18 ,  A61N5/00 ,  A61B18/00 ,  A61N7/00

CPC classification number: A61N1/36007 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/0412 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

公开(公告)号：US08774922B2

公开(公告)日：2014-07-08

申请号：US13898830

申请日：2013-05-21

Applicant: Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Douglas Sutton ,  Howard R. Levin ,  Mark Gelfand

Inventor： Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Douglas Sutton ,  Howard R. Levin ,  Mark Gelfand

IPC: A61N1/00

CPC classification number: A61B18/12 ,  A61B18/04 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61N1/0551 ,  A61N1/36117 ,  A61N7/00 ,  A61N2007/003

Abstract: Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Abstract translation: 提供了方法和装置，例如通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，通过热技术等来治疗对比肾病。这种神经调节可以实现不可逆的电穿孔或电融合，坏死 和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。 在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中，这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。