公开(公告)号：US20140212457A1

公开(公告)日：2014-07-31

申请号：US13965144

申请日：2013-08-12

Applicant: Abdalla Rifai

Inventor： Abdalla Rifai

IPC: C07H17/07 ,  C08B37/02 ,  C08B15/00 ,  C08B37/08

CPC classification number: C08B37/003 ,  A23L33/25 ,  A23L33/26 ,  A23V2002/00 ,  A61K31/00 ,  A61K31/715 ,  A61K31/717 ,  A61K31/722 ,  A61K47/585 ,  A61K47/59 ,  A61K47/61 ,  C07H17/07 ,  C08B3/22 ,  C08B5/04 ,  C08B11/20 ,  C08B15/00 ,  C08B15/06 ,  C08B31/00 ,  C08B37/00 ,  C08B37/0012 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0024 ,  C08B37/0033 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0045 ,  C08B37/006 ,  C08B37/0084 ,  C08B37/0087 ,  C08B37/009 ,  C08B37/0093 ,  C08B37/0096

Abstract: The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as on lipase thus reducing dietary triglyceride metabolism, for use in the treatment of conditions which benefit therefrom (diabetes. Metabolic Syndrome, obesity, prevention of weight gain or aiding weight loss). These compounds comprise a non-absorbable, non-digestible polymer having a glucopyranosyl or galactopyranosyl or equivalent moiety stably and covalently linked thereto, said glucopyranosyl or galactopyranosyl moiety being able to occupy the glucose-binding pocket of a SGLT transporter.

Abstract translation: 本发明涉及能够对Na +葡萄糖协同转运体SGLT具有抑制作用以阻碍葡萄糖和半乳糖吸收的化合物，以及由此降低膳食甘油三酯代谢的脂肪酶用于治疗从中受益的病症 （糖尿病，代谢综合征，肥胖症，预防体重增加或辅助减肥）。 这些化合物包含不可吸收的不可消化的聚合物，其具有稳定且共价连接的吡喃葡萄糖基或吡喃半乳糖基或等效部分，所述吡喃葡萄糖基或吡喃半乳糖基部分能够占据SGLT转运蛋白的葡萄糖结合口袋。

公开(公告)号：US20130243860A1

公开(公告)日：2013-09-19

申请号：US13780875

申请日：2013-02-28

Applicant: EUROFARMA LABORATORIOS S.A. ,  FUNDACAO UNIVERSIDADE DO VALE DO ITAJAI

Inventor： Valdir Cechinel FILHO ,  Tania Mari Belle BRESOLIM ,  Christiane Meire da Silva BITTENCOURT ,  Marcia Maria DE SOUZA ,  Ruth Meri LUCINDA ,  Nara Lins Meira QUINTAO ,  Ticiana Camila MORA ,  Carlos PICOLLI ,  Marcello Creado PEDREIRA ,  Marcelo Eidi NITA ,  Rodrigo SPRICIGO

IPC: A61K31/7048 ,  C07H17/07

CPC classification number: A61K31/7048 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/1623 ,  A61K9/2846 ,  A61K36/47 ,  C07H17/07

Abstract: The present invention refers to a process for obtaining a standardized extract having antinociceptive, anti-inflammatory and antipyretic properties, from at least one part of a plant of genus Aleurites. Furthermore, the present invention provides a pharmaceutical composition comprising an active ingredient of a pharmaceutically efficient quantity of standardized extract from at least one part of the plant of genus Aleurites. Finally, the present invention describes a method of treatment and use of the said extract, isolated or in a pharmaceutical composition, for the prevention, control or treatment of painful, inflammatory or febrile affections.

Abstract translation: 本发明涉及从Aleurites植物的至少一部分获得具有抗伤害感，抗炎和解热性质的标准化提取物的方法。 此外，本发明提供一种药物组合物，其包含来自至少一部分植物的Aleurites的药学上有效数量的标准化提取物的活性成分。 最后，本发明描述了用于预防，控制或治疗疼痛，炎性或发热性感觉的所述提取物，分离的或在药物组合物中的治疗和使用的方法。

公开(公告)号：US20110183930A1

公开(公告)日：2011-07-28

申请号：US13052633

申请日：2011-03-21

Applicant: DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

Inventor： DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

IPC: A61K31/7048 ,  C12P19/60 ,  C07H17/07 ,  A61P35/00 ,  A61P9/00 ,  A61P31/04 ,  A61P37/08 ,  C12P19/44 ,  C07H15/203 ,  A61K31/7034

CPC classification number: C07H17/075 ,  C07H15/203 ,  C07H15/24 ,  C07H15/26 ,  C12P17/02 ,  C12P19/02 ,  C12P19/44 ,  C12P19/60

Abstract: The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.

Abstract translation: 本发明涉及通过将选自邻苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分的酶缩合制备酚衍生物。 所述酚衍生物的生产通过葡糖基转移酶（EC 2.4.1.5）来实现。 所选择的酚类的这些O-α-葡萄糖苷是新的，在水中的溶解度高于其亲本多酚的溶解度，并且在化妆品和药物组合物中有用，例如抗氧化，抗病毒，抗菌，免疫刺激，抗过敏，抗高血压， 抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，血栓形成和抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，抗胆固醇血症，抗脂质过氧化物，肝保护，抗炎，抗致癌，​​抗诱变，抗肿瘤，抗血栓形成和血管扩张制剂。

公开(公告)号：US20110028416A1

公开(公告)日：2011-02-03

申请号：US12919157

申请日：2008-02-25

Applicant: Elizabeth Offord Cavin ,  Gary Williamson ,  Didier Courtois ,  Bernard Lemaure ,  Andre Touche ,  Grace Ing Soon ,  Laurent Ameye

Inventor： Elizabeth Offord Cavin ,  Gary Williamson ,  Didier Courtois ,  Bernard Lemaure ,  Andre Touche ,  Grace Ing Soon ,  Laurent Ameye

IPC: A61K31/7048 ,  C07H17/07 ,  A61P19/10 ,  C07C69/618 ,  C07D311/78 ,  A61K31/366 ,  A61K31/225 ,  A61K31/352 ,  A61P3/02

CPC classification number: A61K36/53 ,  A61K31/366 ,  A61K31/37

Abstract: Compositions and methods for maintenance of bone health or prevention, alleviation and/or treatment of bone disorders are presented. The present invention also provides the manufacture of a nutritional product, a supplement or a medicament for promoting bone growth or for the maintenance of bone health and methods regarding same. In an embodiment, the present invention provides a composition comprising an active ingredient having an effective amount of a plant or plant extract containing at least one phytochemical having the ability to induce bone morphogenic protein expression.

Abstract translation: 提供了用于维持骨骼健康或预防，减轻和/或治疗骨骼疾病的组合物和方法。 本发明还提供了用于促进骨生长或维持骨骼健康的营养产品，补充剂或药物的制造及其相关方法。 在一个实施方案中，本发明提供一种组合物，其包含具有有效量的植物或植物提取物的活性成分，所述植物或植物提取物含有至少一种具有诱导骨形态发生蛋白表达能力的植物化学物质。

公开(公告)号：US07713940B2

公开(公告)日：2010-05-11

申请号：US10556879

申请日：2004-05-19

Applicant: Taketoshi Kido ,  Yoshihisa Iida ,  Takashi Yumoto ,  Toshi Miyake

Inventor： Taketoshi Kido ,  Yoshihisa Iida ,  Takashi Yumoto ,  Toshi Miyake

IPC: A61K31/7048 ,  C07H17/07 ,  C07H1/08

CPC classification number: A61Q19/00 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/498 ,  A61K8/602 ,  A61K31/353 ,  A61K31/7048 ,  A61K2300/00 ,  A23V2250/21172 ,  A23V2250/5112

Abstract: An isoflavone composition which contains an α-glucosyl isoflavone and isoflavone and optionally an isoflavone aglycone, wherein the ratio of the amount of aglycone in the isoflavone and the isoflavone aglycone in total to the amount of aglycone in the α-glucosyl isoflavone [(the amount of aglycone in α-glucosyl isoflavone)/(the amount of aglycone in isoflavone plus the amount of isoflavone aglycone)] is at least 2.5/1; a water-soluble isoflavone composition which contains an α-glucosyl isoflavone, isoflavone and isoflavone aglycone, wherein the ratio of the amount of isoflavone aglycone in the composition is 0.01 to 20% to the total amount of aglycone in the composition; and beverages, cosmetics, pharmaceuticals, or feeds, which contain any one of the above compositions.

Abstract translation: 含有α-葡糖基异黄酮和异黄酮和任选的异黄酮糖苷配基的异黄酮组合物，其中异黄酮和异黄酮苷元中的糖苷配基的总量与α-葡糖基异黄酮中的糖苷配基的量的比[[ 糖苷配基在α-葡萄糖基异黄酮中的量）/（异黄酮中的糖苷配基加上异黄酮糖苷配基的量）]至少为2.5 / 1; 含有α-葡糖基异黄酮，异黄酮和异黄酮糖苷配基的水溶性异黄酮组合物，其中组合物中异黄酮苷元的含量与组合物中糖苷配基总量的比例为0.01〜20％ 以及含有上述组合物中的任一种的饮料，化妆品，药​​物或饲料。

公开(公告)号：US20090221517A1

公开(公告)日：2009-09-03

申请号：US12085741

申请日：2006-11-29

Applicant: David Leach ,  Lesley Stevenson ,  Brigitte Gabriel ,  Karren Beattie

Inventor： David Leach ,  Lesley Stevenson ,  Brigitte Gabriel ,  Karren Beattie

IPC: A61K31/7048 ,  C07H17/07 ,  C07C69/732 ,  A61K31/216 ,  A61P29/00

CPC classification number: C07H17/07 ,  C07D311/30

Abstract: Compounds having useful biological activity, particularly antioxidant and anti-inflammatory activity, derived from Centipeda cunninghamii, and biologically active derivatives thereof, pharmaceutical compositions comprising these compounds, and prophylactic and therapeutic use of the compounds.

Abstract translation: 衍生自蜈蚣蜈蚣的有用生物活性，特别是抗氧化和抗炎活性的化合物及其生物活性衍生物，包含这些化合物的药物组合物，以及该化合物的预防和治疗用途。

公开(公告)号：US20080261898A1

公开(公告)日：2008-10-23

申请号：US12105173

申请日：2008-04-17

Applicant: Heather H. Liao ,  Li Zhan

Inventor： Heather H. Liao ,  Li Zhan

IPC: A61K31/7048 ,  A61K31/352 ,  C07D311/30 ,  A61P35/00 ,  C07H17/07

CPC classification number: C07H17/07 ,  C07D311/30

Abstract: Compounds, compositions, methods and kits are provided for treating, reducing the risk of, or preventing diseases and/or conditions, such as diseases associated with angiogenesis and/or abnormal cell proliferation, such as cancer. Compounds of the present invention have antiangiogenic and anti-cancer activity with minimum toxic effects on normal cells. Methods for preparing and manufacturing the compounds and pharmaceutical compositions are also provided.

Abstract translation: 提供化合物，组合物，方法和试剂盒用于治疗，降低风险，或预防疾病和/或病症，例如与血管生成和/或异常细胞增殖相关的疾病，例如癌症。 本发明的化合物具有抗血管生成和抗癌活性，对正常细胞具有最小的毒性作用。 还提供了制备和制备化合物和药物组合物的方法。

公开(公告)号：US07060470B2

公开(公告)日：2006-06-13

申请号：US10890537

申请日：2004-07-12

Applicant: Jeong Ok Kim ,  Yeong Lae Ha ,  Young Suk Kim ,  Cherl Woo Park

Inventor： Jeong Ok Kim ,  Yeong Lae Ha ,  Young Suk Kim ,  Cherl Woo Park

IPC: C12P19/04 ,  C12N9/42 ,  C12N1/14 ,  C07H17/07 ,  C07H1/00 ,  C07D311/74

CPC classification number: A61K31/7048

Abstract: The present invention relates to low and medium molecular weight isoflavone-β-D-glucan produced by submerged liquid culture of Agaricus blazei, a method of producing the isoflavone-β-D-glucan using autolysis enzyme of Agaricus blazei mycelia, and use of the isoflavone-β-D-glucan for anti-cancer and immunoenhancing effect.

Abstract translation: 本发明涉及通过姬松茸淹水液体培养产生的低分子量和中等分子量的异黄酮-β-D-葡聚糖，该方法是使用姬松茸菌丝体的自溶酶生产异黄酮-β-D-葡聚糖的方法， 异黄酮-β-D-葡聚糖用于抗癌和免疫增强作用。

公开(公告)号：US20050124556A1

公开(公告)日：2005-06-09

申请号：US10493483

申请日：2002-10-24

Applicant: Michael Burton

Inventor： Michael Burton

IPC: C07H15/203 ,  C07H17/07 ,  C12Q1/34 ,  G01N33/58 ,  A61K31/7052 ,  C07H17/02

CPC classification number: C07H15/203 ,  C07H17/07 ,  C12Q1/34 ,  G01N33/581 ,  Y02A50/52

Abstract: This invention provides novel chromogenic enzyme substrates which are indoxyl β-D-ribofuranosides. A process for their production is provided. Methods for detecting β-D-ribofuranosidase activity are given. The advantages of these novel compounds includes: detecting β-D-ribofuranosidase activity with high sensitivity and low substrate concentrations and use with other enzyme indicators in situations where a plurality of enzyme activities is to be visualized simultaneously e.g. for identifying bacteria growth on solid growth media. The synthesis and use of 5-bromo-4-chloro-3-indolyl-β-D-ribofuranoside is exemplified.

Abstract translation: 本发明提供了新的显色酶底物，其为茚氧基β-D-呋喃核糖苷。 提供了一个生产过程。 给出了检测β-D-呋喃核糖酶活性的方法。 这些新型化合物的优点包括：以高灵敏度和低底物浓度检测β-D-呋喃核糖苷酶活性，并在多个酶活性同时显现的情况下与其它酶指示剂一起使用。 用于鉴定固体生长培养基上的细菌生长。 例示了5-溴-4-氯-3-吲哚基-β-D-呋喃核糖苷的合成和应用。

公开(公告)号：US5919921A

公开(公告)日：1999-07-06

申请号：US086658

申请日：1998-05-29

Applicant: Doyle H. Waggle ,  Barbara A. Bryan

Inventor： Doyle H. Waggle ,  Barbara A. Bryan

IPC: C12P17/06 ,  A23J1/14 ,  A23J3/16 ,  C07D311/36 ,  C07D311/40 ,  C07H17/07 ,  C07H1/08 ,  A61K35/78 ,  C07H17/04

CPC classification number: C07D311/40 ,  C07D311/36 ,  C07H17/07

Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.