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    1-disubstituted aminopyrazoles
    12.
    发明授权
    1-disubstituted aminopyrazoles 失效
    1-取代的氨基吡唑

    公开(公告)号：US3694456A

    公开(公告)日：1972-09-26

    申请号：US3694456D

    申请日：1970-05-08

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： NOGUCHI SHUNSAKU ,  KISHIMOTO SHOJI ,  KAWAI KIYOHISA

    IPC: C07D231/12 ,  C07D49/20

    CPC classification number: C07D231/12 ,  Y10S514/906 ,  Y10S514/916

    Abstract: 1-(Disubstituted-amino)pyrazole compounds are provided herein of the formula: WHEREIN EACH OF R1 and R2 stands for lower alkyl or R1 and R2, taken together with the adjacent N-atom form morpholino, piperidino, pyrrolidino, N-methylpiperazino, N-benzylpiperazino and N-phenylpiperazino, R''s, which are the same or different from each other, stand for hydrogen, alkyl having one to ten carbon atoms, phenyl, naphthyl, phenyl or naphthyl substituted by halogen or lower alkyl, respectively, and R3 stands for hydrogen, lower alkyl, N,N-di-loweralkylaminoethyl, N-morpholinomethyl, Npiperidinomethyl, N-pyrrolidinomethyl, N-methylpiperazinomethyl, N-benzylpiperazinomethyl and N-phenylpiperazinomethyl. The above compounds as well as the pharmaceutically acceptable salts thereof are useful as analgesics, antipyretics and mild muscle relaxants.

    Abstract translation: 本文提供下式的1-（二取代 - 氨基）吡唑化合物：

    N-Substituted acrylamides
    17.
    发明授权
    N-Substituted acrylamides 失效
    N-取代的丙烯酰胺

    公开(公告)号：US3878223A

    公开(公告)日：1975-04-15

    申请号：US34062273

    申请日：1973-03-12

    Applicant: ABBOTT LAB

    Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON

    IPC: C07D231/40 ,  C07D261/14 ,  C07D49/20

    CPC classification number: C07D231/40 ,  C07D261/14 ,  Y10S514/87

    Abstract: Acrylamides of N-containing heterocyclic moieties that optionally carry a further hetero atom adjacent to the said N and/or methyl substituent(s) on said hetero ring and at least one chlorine atom adjacent to the double bond of the acrylic moiety have been found to have anti-inflammatory properties at reasonably low dosage levels.

    Abstract translation: 已经发现，含氮杂环部分的丙烯酰胺任选地在所述杂环上邻近所述N和/或甲基取代基和与丙烯酸部分的双键相邻的至少一个氯原子携带另外的杂原子， 在相当低的剂量水平下具有抗炎性质。

    Amino derivatives of pyrazolopyridine ketones
    18.
    发明授权
    Amino derivatives of pyrazolopyridine ketones 失效
    吡唑并吡啶酮的氨基衍生物

    公开(公告)号：US3873556A

    公开(公告)日：1975-03-25

    申请号：US46284674

    申请日：1974-04-22

    Applicant: SQUIBB & SONS INC

    Inventor： DENZEL THEODOR ,  HOEHN HANS

    IPC: C07D231/38 ,  C07D471/04 ,  C07D49/20

    CPC classification number: C07D471/04 ,  C07D231/38

    Abstract: New amino derivatives of pyrazolo(3,4-b)pyridine-5-ketones as well as their salts are useful as central nervous system depressants. These compounds also increase the intracellular concentration of adenosine-3'',5''-cyclic monophosphate.

    Abstract translation: 吡唑并[3,4-b]吡啶-5-酮的新氨基衍生物及其盐可用作中枢神经系统抑制剂。 这些化合物还增加腺苷-3'，5'-环状单磷酸的细胞内浓度。

    Substituted 5-nitrofuryl-pyrazoles
    20.
    发明授权
    Substituted 5-nitrofuryl-pyrazoles 失效
    取代5-硝基吡咯烷酮

    公开(公告)号：US3682953A

    公开(公告)日：1972-08-08

    申请号：US3682953D

    申请日：1970-02-27

    Applicant: GRAHAM ARTON HOWARTH ,  WILLIAM HOYLE

    Inventor： HOWARTH GRAHAM ARTON ,  HOYLE WILLIAM

    IPC: A23K1/16 ,  A61K20060101 ,  C07D20060101 ,  C07D231/14 ,  C07D231/38 ,  C07D307/52 ,  C07D307/54 ,  C07D307/72 ,  C07D49/20

    Abstract: 5-Amino-4-cyano-3-(5-nitro-2-furyl)-pyrazoles, substituted in 1position of the pyrazole moiety by alkyl, hydroxyalkyl or carbalkoxy, and pharmaceutically acceptable acid addition salts thereof, have antimicrobial properties; compositions containing these compounds and methods for the treatment of microbial infections and protecting organic material against microbial attack; a typical embodiment is 5-amino-4-cyano-1-methyl-3-(5nitro-2-furyl)-pyrazole.

    Abstract translation: 在吡唑部分的1位被烷基，羟基烷基或烷氧基取代的5-氨基-4-氰基-3-（5-硝基-2-呋喃基） - 吡唑及其药学上可接受的酸加成盐具有抗微生物性质; 含有这些化合物的组合物和用于治疗微生物感染和保护有机物质免受微生物攻击的方法; 典型的实施方案是5-氨基-4-氰基-1-甲基-3-（5-硝基-2-呋喃基） - 吡唑。

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