公开(公告)号：US3686171A

公开(公告)日：1972-08-22

申请号：US3686171D

申请日：1970-12-02

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  YOUNG PATRICK RICHARD

IPC: C07D231/38 ,  C07D49/20

CPC classification number: C07D231/38 ,  Y10S514/916

Abstract: A NOVEL SERIES OF N''-(4-FORMYL)-5-AMIDO-PYRAZOLES WHICH ARE USEFUL AS INTERMEDIATS IN PREPARING N''-(4(HYDROXYMETHYL)-5-PYRAZOLYL)AMIDINES, THE AMIDINES ARE EFFECTIVE ANTI-FLAMMATORY AGENTS.

公开(公告)号：US3669983A

公开(公告)日：1972-06-13

申请号：US3669983D

申请日：1970-08-20

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D231/38 ,  C07D85/22

CPC classification number: C07D231/38

Abstract: 7,8-Dihydro-4-oxopyrazolo(3,4-d) (1,3)thiazepines which may be substituted in the 1-, 3-, 5-, 7- and/or 8- position and the corresponding isoxazolo(5,4-d) (1,3)thiazepines which may be substituted in the 3-, 5-, 7- and/or 8- position are prepared by converting a 5-aminopyrazole which may be substituted in the 1and/or 3-positions or a 5-aminoisoxazole which may be substituted in the 3-position into a Schiff base and subsequent condensation of the Schiff base with thioglycolic acid or a substituted thioglycolic acid. The new compounds are useful antiinflammatories.

Abstract translation: 可以在1-，3-，5-，7-和/或8-位置被取代的7,8-二氢-4-氧代吡唑并[3,4-d] [1,3]噻吩并与相应的异恶唑并[ 可以在3-，5-，7-和/或8-位置被取代的5,4-d] [1,3]硫杂吗啉是通过将可被取代的5-氨基吡唑转化成1-和/ 或3-位或5-氨基异恶唑，其可以在3-位被取代成席夫碱，随后将席夫碱与巯基乙酸或取代的巯基乙酸缩合。 新化合物是有用的抗炎药。

公开(公告)号：US3544585A

公开(公告)日：1970-12-01

申请号：US3544585D

申请日：1967-10-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  YOUNG PATRICK RICHARD

IPC: C07D231/38 ,  C07D49/20

CPC classification number: C07D231/38

公开(公告)号：US3424844A

公开(公告)日：1969-01-28

申请号：US3424844D

申请日：1967-01-30

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  DARBY THOMAS DILLARD

IPC: A61K31/175 ,  A61K31/27 ,  A61K31/655 ,  A61K27/00 ,  C07C127/12

CPC classification number: C07C247/00

公开(公告)号：US3665008A

公开(公告)日：1972-05-23

申请号：US3665008D

申请日：1970-06-17

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D231/18 ,  C07D495/04 ,  C07D49/18

CPC classification number: C07D495/04 ,  C07D231/18

Abstract: 1,3-Disubstituted-5,6-dihydrothiopyrano(2,3-c) pyrazoles are synthesized from the new 3-((1,3-disubstituted-5pyrazolyl)thio)propionic acids described. The new fused-ring compounds have excellent anti-inflammatory activity; they relieve edemas and are also useful as antipyretics and analgesics.

公开(公告)号：US3590048A

公开(公告)日：1971-06-29

申请号：US3590048D

申请日：1968-04-01

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL

IPC: C07D495/04 ,  C07D65/08

CPC classification number: C07D495/04 ,  Y10S514/87 ,  Y10S514/916

Abstract: 1,3-DISUBSTITUTED-5,6-DIHYDROTHIOPYRANO(2,3-C) PYRAZ OLES ARE SYNTHESIZED FROM THE NEW 3-((1,3-DISUBSTITUTED5-PYRAZOLYL)THIO)PROPIONIC ACIDS DESCRIBED. THE NEW FUSED-RING COMPOUNDS HAVE EXCELLENT ANTI-INFLAMMATORY ACTIVITY; THEY RELIEVE EDEMAS AND ARE ALSO USEFUL AS ANTIPYRETICS AND ANALGESICS.

公开(公告)号：US3476748A

公开(公告)日：1969-11-04

申请号：US3476748D

申请日：1967-01-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  RATAJCZYK JAMES DANIEL ,  KIMURA EUGENE TATSURU

IPC: C07D513/04 ,  C07D93/12 ,  A61K27/00 ,  C07D99/10

CPC classification number: C07D513/04